Patents
Plasma-derived fibrin-based matrices and tissue
Patent Number: 6787357This patent provides matrices that can be generated easily in GMP conditions, and can be administered in combination with various stem cells for therapeutic benefits. Cytokines and other growth factors may also be administered with the stem cells into the matrix to either induce local proliferation, or to chemoattract endogenous stem cells.
Inventors: Bowlin, Gary L. (Mechanicsville, VA); Wnek, Gary (Midlothian, VA); Simpson, David G. (Mechanicsville, VA); Lam, Philippe (Richmond, VA); Carr, Marcus E. (Midlothian, VA); Fillmore, Helen (Richmond, VA)
Assignee: Virginia Commonwealth University (Richmond, VA)
Date of First Priority Issue: Friday September 1st, 2000
Cell expansion system for use in neural transplantation
Patent Number: 6787356This patent teaches methods of generating and expanding dopaminergic neurons that can be used for treatment of a variety of neurological conditions. The system uses, amongst other things, fibroblast growth factor for expansion.
Inventors: Studer, Lorenz (New York, NY); McKay, Ron D. (Bethesda, MD)
Assignee: The United States of America as represented by the Department of Health and Human Services
Date of First Priority Issue: Friday July 24th, 1998
Multipotent neural stem cells from peripheral tissues and uses thereof
Patent Number: 6787355This patent covers multipotent stem cells that are generated from skin or from tongue tissue. This stem cell type is particularly useful for generation of neural stem cells and neurons.
Inventors: Miller, Freda D. (Montreal, CA); Gloster, Andrew (Saskatoon, CA); Toma, Jean (Montreal, CA)
Assignee: McGill University (Montreal, CA)
Date of First Priority Issue: Monday August 26th, 1996
Lineage-restricted neuronal precursors and methods of isolation
Patent Number: 6787353This patent teaches ways of generating a new type of neuronal precursor cell from embryonic tissue. The cells are negative for the marker A2B5 and positive for expression of NCAM.
Inventors: Rao, Mahendra S. (Salt Lake City, UT); Mayer-Proschel, Margot (Sandy, UT); Kalyani, Anjali J. (Salt Lake City, UT)
Assignee: University of Utah Research Foundation (Salt Lake City, UT)
Date of First Priority Issue: Friday July 4th, 1997
Inhibitor and stimulator of stem cell proliferation and uses thereof
Patent Number: 6784155The connection between the brain and the immune system is well-known, such as the experiments of Pavlovian conditioning of immune responses. Here the inventor covers the use of opiates and certain peptides for stimulation of bone marrow stem cell proliferation. Specific peptide sequences of hematopoietic stem cell stimulators are disclosed including peptide fractions of hemoglobin chains...
Inventors: Wolpe, Stephen D. (Rockville, MD); Tsyrlova, Irena (Gaithersburg, MD)
Assignee: Wellstat Therapeutics Corporation (Gaithersburg, MD)
Date of First Priority Issue: Wednesday April 3rd, 1996
Proteins related to neuronal regeneration and uses thereof
Patent Number: 6783982This patent teaches that neural stem cells can be expanded through the use of a novel protein called Neural Plakophilin Related Armadillo Protein (hNPRAP). Additionally the patent claims the induction of cellular extensions ushing hNPRAP.
Inventors: St. George-Hyslop, Peter H. (Toronto, CA); Fraser, Paul E. (Toronto, CA)
Assignee: The Governing Council of The University of Toronto (Toronto, CA)
Date of First Priority Issue: Friday February 12th, 1999
Serum-derived factor inducing cell differentiation and medical uses thereof
Patent Number: 6783775This patent teaches ways of inducing differentiation in stem cells. Specifically it claims a composition of matter that can induce not only differentiation of hematopoietic stem cells, but also of leukemic cells. The composition contains the enzyme ceruloplasmin, together with a specific serum derived component. This patent is ripe for commercialization.
Inventors: Peled, Tony (Mevaseret Zion, IL); Fibach, Eitan (Mevaseret Zion, IL); Rachmilewitz, Eliezer A. (Jerusalem, IL)
Assignee: Hadasit Medical Research Services and Development Ltd. (Jerusalem, IL)
Date of First Priority Issue: Tuesday December 10th, 1996
Methods for cloning mammals using telophase oocytes
Patent Number: 6781030This patent teaches a new way of cloning, including for the generation of embryonic stem cells, by selecting oocytes at a specific cell stage called telophase.
Inventors: Baguisi, Alexander (Grafton, MA); Overstrom, Eric W. (Grafton, MA)
Assignee: Trustee of Tufts College, Ballou Hall (Medford, MA)
Date of First Priority Issue: Monday November 2nd, 1998
Cultures of human CNS Neural stem cells
Patent Number: 6777233This patent provides a tissue culture media and systems that can be used to expand nestin positive neural stem cells. The neural stem cells that are expanded in this patent have more potency and appear to be more undifferentiated than neural stem cells that are covered in the prior art.
Inventor: Carpenter, Melissa (Foster City, CA)
Assignee: StemCells California, Inc. (Palo Alto, CA)
Date of First Priority Issue: Friday September 5th, 1997
Adipose-derived stem cells and lattices
Patent Number: 6777231This is one of the founding patents covering work performed by Cytori, formerly Macropore. The patent covers an adipose derived stem cell that can diffentiate into bone, cartilage cell, nerve, or muscle cells.
Inventors: Katz, Adam J. (Charlottesville, VA); Llull, Ramon (Mallorca, ES); Futrell, William J. (Pittsburgh, PA); Hedrick, Marc H. (Encino, CA); Benhaim, Prosper (Los Angeles, CA); Lorenz, Hermann Peter (Los Angeles, CA); Zhu, Min (Los Angeles, CA)
Assignee: The Regents of the University of California (Oakland, CA)
Date of First Priority Issue: Wednesday March 10th, 1999