Patents
Method of transluminal application of myogenic cells for repair or replacement of heart tissue
Patent Number: 6805860This patent appears to cover the tempory occlusion of a vessel so that stem cells can be administered for repair of the injured organ. This patent has the potential to cover various clinical applications of stem cell therapies, especially for myocardial infarction that use a balloon stent to localize the stem cells into the infarct related artery.
Inventor: Alt, Eckhard (D-85521 Ottobrunn, DE)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Sunday September 30th, 2001
Method for maintenance and propagation of germline stem cells using members of the TFG-.beta. family of growth factors
Patent Number: 6800790This patent teaches how to increase the number of germline stem cells in a fruitfly through overexpression of Dpp locally using certain promoters that are specific to germline stem cells. Since the patent is only covering the fruitfly species, clinical applications seem to be limited.
Inventors: Spradling, Allan C. (Baltimore, MD); Xie, Ting (Baltimore, MD)
Assignee: Carnegie Institution of Washington (Washington, DC)
Date of First Priority Issue: Friday July 24th, 1998
Methods and materials for the growth of primate-derived primordial stem cells in feeder-free culture
Patent Number: 6800480This patent teaches how to grow embryonic stem cells in absence of feeder cells. This is a useful "base patent" that is essential to generation of therapeutics from embryonic stem cells, since it is usually not desired to use feeder cell layers in culture of embryonic stem cells for clinical use.
Inventors: Bodnar, Andrea G. (Oshawa, CA); Chiu, Choy-Pik (Cupertino, CA); Gold, Joseph D. (San Francisco, CA); Inokuma, Margaret (San Jose, CA); Murai, James T. (San Bruno, CA); West, Michael D. (Boston, MA)
Assignee: Geron Corporation (Menlo Park, CA)
Date of First Priority Issue: Thursday October 23rd, 1997
Mesenchymal stem cells as immunosuppressants
Patent Number: 6797269This patent covers mesenchymal stem cells that are treated with interferon gamma for suppression of an immune response. Mesenchymal stem cells are naturally immunosuppressive...it may be that the interferon gamma treatment is activating the expression of the immune suppressive enzyme 2,3-indolamine-dehydrogenase (IDO), which selectively depletes tryptophan, thus stopping T cell activation.
Inventors: Mosca, Joseph D. (Ellicott City, MD); McIntosh, Kevin R. (Ellicott City, MD)
Assignee: Osiris Therapeutics, Inc. (Baltimore, MD)
Date of First Priority Issue: Friday April 3rd, 1998
Medicinal product and method for treatment of conditions affecting neural stem cells or progenitor cells
Patent Number: 6797264This patent covers the use of neural stem cells together with a growth hormone for treatment of neurological conditions. This covers various hormones including growth hormone itself, as well as fibroblast growth factor.
Inventor: Eriksson, Peter (Goteborg, SE)
Assignee: Cellartis AB (Goteborg, SE)
Date of First Priority Issue: Wednesday November 25th, 1998
Biomaterial derived from vertebrate liver tissue
Patent Number: 6793939This patent covers the use of liver tissue derived basement membrane material for the stimulation of endogenous or exogenous stem cells. One interesting use of this patent would be the combination of cord blood stem cells with liver tissue extract for stimulation of various regenerative applications.
Inventor: Badylak, Stephen F. (West Lafayette, IN)
Assignee: Purdue Research Foundation (West Lafayette, IN)
Date of First Priority Issue: Tuesday December 10th, 1996
Method of providing cells and other biologic materials for transplantation
Patent Number: 6793677This patent teaches ways of using cells and stem cells from the nucleus pulposus for the treatment of degenerative back diseases. Since lower back pain is a major medical concern, various stem cell therapeutics are being considered for stimulation of the nucleus pulposus cellular content, so as to regenerate degenerate discs. The cells used in this patent do not necessarily have to be...
Inventor: Ferree, Bret A. (Cincinnati, OH
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Friday August 13th, 1999
Combinations and methods for promoting in vivo liver cell proliferation and enhancing in vivo liver-directed gene transduction
Patent Number: 6790838This patent teaches ways of improving the transfection of liver cells with genes in vivo. Transfection of liver cells is performed through the administration of the thyroid hormone T3, as well as keratinocyte growth factor. The transfection of liver cells may be performed not only for treatment of genetic disorders, but also for induction of islet differentiation.
Inventors: Alison, Malcolm R. (London, GB); Coutelle, Charles (London, GB); Forbes, Stuart J. (London, GB); Hodgson, Humphrey J. F. (London, GB); Sarosi, Ildiko (Newbury Park, CA); Themis, Michael (Oxfordshire, GB)
Assignee: Amgen, Inc. (Thousand Oaks, CA); Imperial College Innovations LTD (London, GB)
Date of First Priority Issue: Tuesday February 23rd, 1999
Human haemopoietic maturation factor
Patent Number: 6790826This patent covers composition of matter on a factor, which seems to be not clearly stated, that can induce both proliferation and differentiation of hematopoietic stem cells, as well as stem cells that have been committed to the lymphoid lineage. This patent is particularly useful for treatment of patients after bone marrow transplantation, or chemotherapy, or radiation therapy.
Inventors: Kirkness, Ewen F. (Olney, MD); Adams, Mark D. (Rockville, MD); Olsen, Henrik (Gaithersburg, MD); Rosen, Craig A. (Laytonsville, MD)
Assignee: Human Genome Sciences, Inc. (Rockville, MD)
Date of First Priority Issue: Tuesday May 16th, 1995
Cell delivery system comprising a fibrous matrix and cells
Patent Number: 6790455This patent teachs cell delivery matrices that can be used for localized administration of stem cells into an area of need. The matrices disclosed are biocompatible and biodegradable. The patent is owned by a non-for-profit entity and appears to be available for licensing.
Inventors: Chu, Benjamin (Setauket, NY); Hsiao, Benjamin S. (Setauket, NY); Hadjiargyrou, Michael (Coram, NY); Fang, Dufei (Painted Post, NY); Zong, Xinhua (Centereach, NY); Kim, Kwangsok (Setauket, NY)
Assignee: The Research Foundation at State University of New York (Stony Brook, NY)
Date of First Priority Issue: Friday September 14th, 2001