Patents
Method of isolating adult mammalian CNS-derived progenitor stem cells using density gradient centrifugation
Patent Number: 6767738This patent teaches ways of using gradient centrifugation (separation based on weight) to purify stem cells of the neural lineage from adults. This is specifically useful since it is a relatively easy way to purify cells and is commonly used in the purification of hematopoietic stem cells.
Inventors: Gage, Fred H. (La Jolla, CA); Palmer, Theo (San Carlos, CA); Safar, Francis G. (Irvine, CA); Takahashi, Jun (Kyoto, JP); Takahashi, Masayo (Kyoto, JP)
Assignee: The Salk Institute for Biological Studies (La Jolla, CA)
Date of First Priority Issue: Friday September 24th, 1999
Stem cells bearing an FGF receptor on the cell surface
Patent Number: 6767737This patent is on a type of stem cell that expresses the fibroblast growth factor receptor. This is a composition of matter patent on a stem cell and could be very useful for strategic positioning of companies in the area of stem cell therapeutics.
Inventors: Wilson, E. Lynette (New York, NY); Burger, Patricia E. (Cape Town, ZA)
Assignee: New York University (New York, NY)
Date of First Priority Issue: Monday August 31st, 1998
Loop peptide and TGF.alpha. for stimulating stem cell proliferation and migration
Patent Number: 6764683Mucositis is a big problem in cancer patients taking chemotherapy and radiation therapy, in part due to the effect of these therapies on the epithelial stem cell pool. This patent teaches the usefulness of transforming growth factor alpha on preventing this condition by its ability to protect the stem cell compartment and to enhance their expansion.
Inventors: Twardzik, Daniel R. (Bainbridge Island, WA); Paskell, Stefan (Bainbridge Island, WA); Felker, Thomas S. (Vashon, WA)
Assignee: Kaleidos Pharma, Inc. (Seattle, WA)
Date of First Priority Issue: Monday April 26th, 1999
Methods for treating a patient undergoing chemotherapy
Patent Number: 6762167This patent teaches that angiotensin I and/or angiotensin II can be used for stimulation of hematopoiesis.
Inventors: Rodgers, Kathleen E. (Long Beach, CA); DiZerega, Gere S. (Los Angeles, CA)
Assignee: University of Southern California (Los Angeles, CA)
Date of First Priority Issue: Wednesday March 11th, 1998
Alginate layer system for chondrogenic differentiation of human mesenchymal stem cells
Patent Number: 6761887Mesenchymal stem cells can be used as "universal donors" since they do not elicit rejection in certain situations. This patent teaches methods of differentiating mesenchymal stem cells into cartilage through growth on alginate layers.
Inventors: Kavalkovich, Karl (Baltimore, MD); Boynton, Raymond (Watertown, MA); Murphy, Mary (Baltimore, MD); Barry, Frank (Baltimore, MD)
Assignee: Osiris Therapeutics, Inc. (Baltimore, MD)
Date of First Priority Issue: Monday November 16th, 1998
Mammalian myeloid progenitor cell subsets
Patent Number: 6761883This is a composition of matter patent on stem cells of the hematopoietic lineage that differentiate specifically into myeloid cells under the appropriate culture and/or in vivo conditions. These stem cells may be used as a "boost" for patients in which the myeloid compartment is not repopulating after bone marrow transplant, or chemotherapy, or radiation therapy.
Inventors: Weissman, Irving L. (Redwood City, CA); Traver, David Jeffrey (West Roxbury, MA); Akashi, Koichi (Palo Alto, CA); Manz, Markus Gabriel (Palo Alto, CA); Miyamoto, Toshihiro (Menlo Park, CA)
Assignee: The Board of Trustees of the Leland Stanford Junior University (Palo Alto, CA)
Date of First Priority Issue: Tuesday June 29th, 1999
Human neuronal attachment factor-1
Patent Number: 6759512This patent covers a protein called F-spondin that is involved in regulation of development and stem cell function. It is published that F-spondin induces differentiation of neural stem cells into neurons (Schubert D et al. F-spondin promotes nerve precursor differentiation. J Neurochem. 2006 Jan;96(2):444-53).
Inventors: Hastings, Gregg (Newberry Park, CA); Dillon, Patrick J. (Gaithersburg, MD)
Assignee: Human Genome Sciences, Inc. (Rockville, MD)
Date of First Priority Issue: Monday February 12th, 1996
Cell culture systems and methods for organ assist devices
Patent Number: 6759245Ex vivo culture of stem cells is important for the generation of artificial organs. This patent teaches culture of stem cells and precursor cells using a unique culture set up that allows for proper differentiation of cells in an in vivo like setting. The patent is primarily targeted towards the generation of hepatocytes.
Inventors: Toner, Mehmet (Wellesley, MA); Tilles, Arno W. (Cambridge, MA); Balis, Ulysses J. (Peabody, MA); Yarmush, Martin L. (Newton, MA); Cosman, Maury D. (Woburn, MA); Dimilla, Paul A. (Dover, MA)
Assignee: The General Hospital Corporation (Boston, MA); Organogenesis Inc. (Canton, MA)
Date of First Priority Issue: Monday June 21st, 1999
Composite blastocysts (CBs) from aggregates of dissociated cells of non-viable pre-embryos
Patent Number: 6759244This patent teaches methods of generating a composite blastocyst from non-viable embryos. The invention is useful for generation of stem cells of embryonic origin through a novel method.
Inventors: Alikani, Mina (New York, NY); Willadsen, Steen Malte (Windermere, FL)
Assignee: Art Institute of New York and New Jersey, Inc. (New York, NY)
Date of First Priority Issue: Thursday November 8th, 2001
Low oxygen culturing of neural crest stem cells and methods of use
Patent Number: 6759242This patent teaches that neural stem cells, specifically neural crest stem cells, can be expanded preferentially by growing in low oxygen conditions.
Inventors: Csete, Marie (S. Pasadena, CA); Morrison, Sean J. (Ann Arbor, MI); Wold, Barbara (San Marino, CA); Anderson, David J. (Altadena, CA)
Assignee: California Institute of Technology (Pasadena, CA)
Date of First Priority Issue: Wednesday November 18th, 1998