Patents
Bone precursor cells: compositions and methods
Patent Number: 6740493This patent teaches how to diagnose, or to predict a bone disease through identifying the bone stem cell content and activity of the patient.
Inventors: Long, Michael W. (Northville, MI); Mann, Kenneth G. (Grand Isle, VT)
Assignee: The Regents of the University of Michigan (Ann Arbor, MI)
Date of First Priority Issue: Friday August 12th, 1994
Implant for repairing cartilage having outer surface layers of copolymer and ceramic material
Patent Number: 6737073This is an implantable matrix that can be used for growing stem cells in vitro for the regeneration of cartilage. The implant has several advantages over the prior art including the fact that it is compartamentalized in structure to provide a more "in vivo" like function.
Inventors: Mahmood, Tahir (Cambridge, MA); Riesle, Jens Uwe (Amsterdam, NL); van Blitterswijk, Clemens Antoni (Hekendorp, NL)
Assignee: IsoTis N.V. (Bilthoven, NL)
Date of First Priority Issue: Wednesday February 10th, 1999
Matrix for tissue engineering formed of a hyaluronic acid ester and hydrolyzed collagen
Patent Number: 6737072This patent covers a matrix that is made of hyaluronic acid and hydrolyzed collagen, that can be used as a scaffold for in vitro three dimensional tissue generation, or can be seeded with stem cells and implanted in vivo.
Inventors: Angele, Peter (Regensburg, DE); Kujat, Richard (Pettendorf, DE)
Assignee: Nerlich, Michael (Pentling, DE)
Date of First Priority Issue: Saturday December 3rd, 1988
Myocardial grafts and cellular compositions useful for same
Patent Number: 6737054This patent teaches administration of stem cells, or cardiomyocytes, into areas of the heart that have been injured, including by infarction.
Inventor: Field, Loren J. (Indianapolis, IN)
Assignee: Advanced Research and Technology Institute (Indianapolis, IN)
Date of First Priority Issue: Thursday December 16th, 1993
Delivery device for biological composites and method of preparation thereof
Patent Number: 6736799This patent covers a device for administration of biological matrices that can be co-implanted with stem cells for regenerative purposes.
Inventors: Erbe, Erik M. (Berwyn, PA); Marx, Jeffrey G. (Downington, PA); Bagga, Charanpreet S. (Phoenixville, PA)
Assignee: Vita Licensing, Inc. (Wilmington, DE)
Date of First Priority Issue: Tuesday October 24th, 2000
Transfection, storage and transfer of male germ cells for generation of transgenic species and genetic therapies
Patent Number: 6734338This patent teaches how to transfect male germ stem cells in non-human mammals. This technology is useful for generation of a variety of animal models for laboratory experimentation. It is also useful for research companies who want to circumvent some of the transgenic patents today.
Inventors: Readhead, Carol W. (Pasadena, CA); Winston, Robert (London, GB)
Assignee: Cedars-Sinai Medical Center (Los Angeles, CA); IMPEL, Imperial College of Science, Technology and Medicine (London, GB)
Date of First Priority Issue: Friday November 14th, 1997
Isolation of lineage-restricted neuronal precursors
Patent Number: 6734015This patent covers a type of neuronal stem cell that is restricted in its differentiation ability to the neuronal, but not astrocyte or glial lineage. The patent covers a cell that is E-NCAM positive, FGF-dependent, and derived from embryonic sources.
Inventors: Rao, Mahendra S. (Salt Lake City, UT); Mayer-Proschel, Margot (Sandy, UT)
Assignee: University of Utah Research Foundation (Salt Lake City, UT)
Date of First Priority Issue: Friday July 4th, 1997
Hematopoietic cell culture nutrient supplement
Patent Number: 6733746This patent covers a tissue culture media useful for the expansion of CD34+ hematopoietic stem cells that does not require the use of serum, and thus is easier for clinical implimentation. The patent is owned by Invitrogen which sells various laboratory and tissue culture reagents.
Inventors: Daley, John P. (Buffalo, NY); Dadey, Barbara M. (East Aurora, NY); Biddle, William C. (Buffalo, NY); Wysocki, Michelle G. (Cheektowaga, NY)
Assignee: Invitrogen Corporation (Carlsbad, CA)
Date of First Priority Issue: Tuesday March 12th, 1996
Blood separation system particularly for concentrating hematopoietic stem cells
Patent Number: 6733433This patent covers a medical device that is useful for the concentration of stem cells, especially hematopoietic stem cells, from peripheral blood and other fluids.
Inventor: Fell, Claude (Nyon, CH)
Assignee: Biosafe S.A. (Eysins, CH)
Date of First Priority Issue: Thursday December 24th, 1998
Medium and matrix for long-term proliferation of cells
Patent Number: 6730315This patent covers a hydrogel mixture that is useful for storage and/or expansion of cells, especially useful for stem cell applications. This technology may be used to form an in vivo depot of stem cells, or may be embedded with stem cell chemoattractants to call in endogenous stem cells into an area of need.
Inventors: Usala, Anton-Lewis (Winterville, NC); Klann, Richard Chris (Washington, NC)
Assignee: Encelle, Inc. (Greenville, NC)
Date of First Priority Issue: Monday February 24th, 1992