Patents
Cord blood-derived activated lymphocytes, preparations containing said lymphocytes as main ingredient and method and kit for producing said preparations
Patent Number: 6692958This patent provides methods of expanding cord blood cells to generate T cells in vitro, and the subsequent use of the T cells for immunotherapy. The patent also covers other types of lymphocytes such as B cells, and NK cells.
Inventors: Sekine, Teruaki (Tokyo, JP); Ito, Kiminari (Hokkaido, JP); Shimizu, Norio (Yamanashi, JP); Bamba, Kenzo (Ibaraki, JP); Yamaguchi, Tomohiro (Saitama, JP); Kuroiwa, Yasuyuki (Ibaragi, JP)
Assignee: Humantec Ltd. (Ibaraki-ken, JP)
Date of First Priority Issue: Monday December 4th, 2000
Scaffold for tissue engineering cartilage having outer surface layers of copolymer and ceramic material
Patent Number: 6692761This patent covers scaffolds that can be seeded with cells and/or growth factors so as to promote regeneration of cartilage.
Inventors: Mahmood, Tahir (Cambridge, MA); Riesle, Jens Uwe (Amsterdam, NL); van Blitterswijk, Clemens Antoni (Hekendorp, NL)
Assignee: IsoTis N.V. (Bilthoven, NL)
Date of First Priority Issue: Wednesday February 10th, 1999
Delivery of therapeutic biologicals from implantable tissue matrices
Patent Number: 6692738This patent covers compositions of matter that can be used to deliver proteins to tissue. The matrices described in this patent can be seeded with cells for delivery of stem cells together with the therapeutic protein. In some embodiements of the patent the therapeutic protein can be an antibody, a growth factor, or a cytokine.
Inventors: MacLaughlin, David T. (Saugus, MA); Vacanti, Joseph P. (Winchester, MA); Donahoe, Patricia K. (Boston, MA); Masiakos, Peter T. (Boston, MA)
Assignee: The General Hospital Corporation (Boston, MA)
Date of First Priority Issue: Thursday January 27th, 2000
Biological pacemaker and implantation catheter
Patent Number: 6690970This patent covers the use of stem cells and products of stem cells as "biological pacemakers" so as to ensure that the electrical pulses of the heart are appropriately coordinated.
Inventors: Taheri, Syde A. (Buffalo, NY); Leonhardt, Howard J. (Weston, FL)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Friday October 6th, 2000
Use of GM-CSF to promote accelerated wound healing
Patent Number: 6689351This patent teaches that the hematopoietic stem cell stimulatory cytokine GM-CSF, which is clinically used today, can also be used for acceleration of wound healing when applied topically. This brings the question of what other stem cell stimulatory cytokines may be used to stimulate regeneration or healing of other tissues? The sky is the limit !!
Inventors: Pierce, Glenn (Thousand Oaks, CA); Altrock, Bruce W. (Newbury Park, CA) )
Assignee: Amgen Inc. (Thousand Oaks, CA
Date of First Priority Issue: Friday February 22nd, 1991
Surface modifications for enhanced epithelialization
Patent Number: 6689165This patent teaches how to accelerate healing of epithelial cells of the cornea through administration of an optical polymer that consists, in part of a hydrogel. The devices and compositions thought are useful for stimulation of stem cells associated with production of corneal epithelial cells.
Inventors: Jacob, Jean T. (New Orleans, LA); Bi, Jingjing (River Ridge, LA)
Assignee: Board of Supervisors of Louisana State University and Agricultural and Mechanical College (Baton Rouge, LA)
Date of First Priority Issue: Wednesday May 31st, 2000
Regulators of the hedgehog pathway, compositions and uses related thereto
Patent Number: 6686388Like many biological pathways activated in stem cells, the pathways associated with hedgehog signalling are also associated with cancer. In this invention methods of modulating the hedgehog signalling pathway are provided that can be useful for controlling normal stem cells, as well as cancer cells.
Inventors: Dudek, Henryk (Wellesley, MA); Ji, Benxiu (Sharon, MA)
Assignee: Curis, Inc. (Cambridge, MA)
Date of First Priority Issue: Wednesday January 13th, 1999
Method of inducing and maintaining neuronal cells
Patent Number: 6686198This patent teachs how to induce neural differentiation of stem cells through activation of the activin receptor associated pathways. One wonders if this patent is also applicable to bone marrow stem cells, or bone marrow stem cells induced to dedifferentiated by epigenetic modification.
Inventors: Melton, Douglas A. (Lexington, MA); Hemmati-Brivanlou, Ali (New York, NY)
Assignee: President and Fellows of Harvard College (Cambridge, MA)
Date of First Priority Issue: Thursday October 14th, 1993
Methods and compositions for modulating telomerase reverse transcriptase (TERT) expression
Patent Number: 6686159Telomerase induces cellular escape from sensence and is important for stem cell activity, as well as for cancer to becoming immortal. In this patent agents are identified that suppress the suppressor of telomerase, therapy allowing various types of cells to express telomerase and thereby escape senescence.
Inventors: Andrews, William H. (Reno, NV); Foster, Christopher A. (Carmichael, CA); Fraser, Stephanie (Sparks, NV); Mohammadpour, Hamid (Reno, NV)
Assignee: Sierra Sciences, Inc. (Reno, NV)
Date of First Priority Issue: Friday September 1st, 2000
Method and composition for repairing and promoting regeneration of mucosal tissue in the gastrointestinal tract
Patent Number: 6685971This patent teaches methods of increasing activity of stem cells in the gastrointestinal tract through administration of a beeswax based composition. This patent is useful for treatment of various gastrointestinal disorders.
Inventor: Xu, Rongxiang (Arcadia, CA)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Thursday June 28th, 2001