Patents
Suppressor cells induced by culture with mesenchymal stem cells for treatment of immune responses in transplantation
Patent Number: 6685936In an effort to solidify its IP wall, Osiris decided not only to cover immune suppression by mesenchymal stem cells, but also the ability of mesenchymal stem cells to elicit other immunosuppressive cells. In this patent to ability of mesenchymal stem cells to activate/expand suppressor T cells, and other types of immune suppressor cells is covered.
Inventors: McIntosh, Kevin (Ellicott City, MD); Klyushnenkova, Elena (Baltimore, MD)
Assignee: Osiris Therapeutics, Inc. (Baltimore, MD)
Date of First Priority Issue: Tuesday October 12th, 1999
In vitro activation of mammalian oocytes
Patent Number: 6680199This is one of the patents that teaches how to activate oocytes into parthenogenesis (ie without the male side). This patent is useful for generation of pathenogenically-derived embryonic stem cells.
Inventors: Susko-Parrish, Joan L. (Monona, WI); Northey, David L. (Madison, WI); Leibfried-Rutledge, M. Lorraine (Madison, WI); Stice, Steven L. (DeForest, WI)
Assignee: Infigen, Inc. (Deforest, WI)
Date of First Priority Issue: Wednesday February 10th, 1993
Engraftable human neural stem cells
Patent Number: 6680198This patent teaches a type of neuronal stem cell that can be used for cell therapy of neurological disorders. Characterization of the cell is provided and includes expression of EGF and FGF receptors.
Inventors: Snyder, Evan Y. (Jamaica Plain, MA); Wolfe, John H. (Philadelphia, PA); Kim, Seung U. (Vancouver, CA)
Assignee: The Children's Medical Center Corporation (Boston, MA); University of British Columbia (Vancouver, GB); University of Pennsylvania (Philadelphia, PA)
Date of First Priority Issue: Friday August 14th, 1998
Devices and methods for harvesting limbal stem cells
Patent Number: 6679898This patent provides a medical device and ways to use the device to extract corneal tissue and limbal stem cells from the eye of a donor.
Inventor: Chuck, Roy S. (Irvine, CA)
Assignee: The Regents of the University of California (Oakland, CA
Date of First Priority Issue: Wednesday September 27th, 2000
Electrical field therapy with reduced histopathological change in muscle
Patent Number: 6678556This patent covers ways of in vivo transfecting cells by means of electroporation without inducing inflammatory or tissue damaging changes. I have included this in the "expansion" section of the StemCellPatents.Com database since electroporation can be used for cytoplasmic transfect of cytoplasm from embryonic stem cells into various tissues, so as to endow the tissues with stem cell like...
Inventors: Nolan, Edward (San Diego, CA); Rabussay, Dietmar P. (Solana Beach, CA); Widera, Georg (Del Mar, CA); Zhang, Lei (San Diego, CA) A)
Assignee: Genetronics, Inc. (San Diego, C
Date of First Priority Issue: Monday July 13th, 1998
TGF-.alpha. polypeptides, functional fragments and methods of use therefor
Patent Number: 6677307This patent discloses compositions of transforming growth factor alpha peptides and pharmaceutical preparations thereof. The patent is useful for expanding certain stem cells that respond to this cytokine. One potential use is for treatment of mucositis.
Inventors: Twardzik, Daniel R. (Bainbridge Island, WA); Pernet, Andre (Lake Forest, IL); Felker, Thomas S. (Vashon, WA); Paskell, Stefan (Bainbridge Island, WA); Reno, John M. (Brier, WA)
Assignee: Kaleidos Pharma, Inc. (Seattle, WA)
Date of First Priority Issue: Thursday August 19th, 1999
Patterned substrates and methods for nerve regeneration
Patent Number: 6676675This patent provides biocompatible surfaces which can be used for growing nerve cells on that are derived from stem cells. This type of technology will be critical for generation of neural networks in vitro and in vivo, and eventually for the ability to expand central nervous system function.
Inventors: Mallapragada, Surya K. (Ames, IA); Heath, Carole (Seattle, WA); Shanks, Howard (Ames, IA); Miller, Cheryl A. (Irvine, CA); Jeftinija, Srdija (Ames, IA)
Assignee: Iowa State University Research Foundation, Inc. (Ames, IA)
Date of First Priority Issue: Wednesday April 19th, 2000
Low intensity light therapy for the manipulation of fibroblast, and fibroblast-derived mammalian cells and collagen
Patent Number: 6676655This patent provides frequencies of light that effect extracellular and cellular components. This patent is useful for regulation of stem cells after implantation into a host through non-pharmacological means.
Inventor: McDaniel, David H. (Virginia Beach, VA)
Assignee: Light BioScience L.L.C. (Virginia Beach, VA)
Date of First Priority Issue: Monday November 30th, 1998
Stem cell growth factor-like polypeptides
Patent Number: 6673904This is a composition of matter patent that can be used for developing into a pharmaceutical for stem cell stimulation and differentiation. The composition provided is a stimulator of stem cells, both of hematopoietic and non-hematopoietic lineages.
Inventors: Nishikawa, Mitsuo (Gunma, JP); Labat, Ivan (Mountain View, CA); Drmanac, Radoje T. (Palo Alto, CA); Tang, Y. Tom (San Jose, CA); Chao, Cheng-Chi (Cupertino, CA); Mize, Nancy (Mountain View, CA); Childs, John (Sunnyvale, CA)
Assignee: Kirin Beer Kabushiki Kaisha (Tokyo, JP); Hyseq, Inc. (Sunnyvale, CA)
Date of First Priority Issue: Saturday December 23rd, 2000
Therapeutic uses for mesenchymal stromal cells
Patent Number: 6673606This patent teaches how to induce the differentiation of mesenchymal stem cells into oligodendrocyte cells. These oligodendrocytes may be used for treatment of various metabolic and nervous system disorders.
Inventors: Tennekoon, Gihan (Wynnewood, PA); Coyle, Andrew J. (Philadelphia, PA); Grinspan, Judith (Ardmore, PA); Beesley, Jackie S. (West Sussex, GB)
Assignee: The Children's Hospital of Philadelphia (Philadelphia, PA
Date of First Priority Issue: Wednesday April 12th, 2000