Patents
Muscle cells and their use in cardiac repair
Patent Number: 6673604This is a composition patent covering myocardial and fibroblast cell preparations that are useful for administration in the post-infarct myocardium. This approach is interesting and a similar approach seems to have been used clinically by the company Bioheart.
Inventor: Edge, Albert (Cambridge, MA)
Assignee: Diacrin, Inc. (Charlestown, MA)
Date of First Priority Issue: Friday July 23rd, 1999
Histone deacetylase, and uses therefor
Patent Number: 6673587This is a composition of matter patent on several proteins that function as histone deacetylases. Histone deacetylases act at an epigenetic level through modifying histones and controlling gene transcription. Manipulation of histone deacetylase activity can be used to change cellular fate.
Inventors: Evans, Ronald M. (La Jolla, CA); Kao, Hung-Ying (San Diego, CA); Downes, Michael (San Diego, CA); Ordentlich, Peter (San Diego, CA)
Assignee: The Salk Institute for Biological Studies (La Jolla, CA)
Date of First Priority Issue: Friday August 11th, 2000
Method for detecting hematopoietic stem cells
Patent Number: 6670123This patent teaches the identification of stem cells by virtue of expression of the gene known as KIAA0918. Specifically, the claims are aimed at hematopoietic stem cells and detection by hybridization. It will be interesting to identify the protein and function of the protein encoded by the gene KIAA0918.
Inventors: Belyavsky, Alexander (New York, NY); Shmelkov, Sergey (Union City, NJ); Visser, Jan (New York, NY)
Assignee: New York Blood Center, Inc. (New York, NY)
Date of First Priority Issue: Friday November 3rd, 2000
Method and system for myocardial infarction repair
Patent Number: 6671558This patent covers a method of preventing heart failure after a myocardial infarction through the administration of stem cells, together with a device that induces electrical signals. In some embodiments the stem cells are transfected with genetic material to modify functions (ie increased contractility: transfect with SERCA-2, increase angiogenesis: transfect with FGF, etc).
Inventors: Soykan, Orhan (Shoreview, MN); Donovan, Maura G. (St. Paul, MN)
Assignee: Medtronic, Inc. (Minneapolis, MN)
Date of First Priority Issue: Friday November 7th, 1997
Methods for transdifferentiation of body tissues
Patent Number: 6670397This patent has some pretty broad claims. It teaches to repair tissue by inducing de-differentiation of cells, and then stimulating redifferentiation into another histological cell type. This patent may be very strong ammunition against companies active in the area of stem cell therapy that have not licensed it.
Inventor: Baranowitz, Steven (Apt. 519 Wyncote, PA)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Sunday August 29th, 1999
Stem cell growth factor-like polypeptide
Patent Number: 6667391This patent provides peptides and various compositions of matter that are useful for stimulation of stem cell proliferation. It is unclear what the biological analogues of these peptides are, but they seem very useful for anyone seeking to enter the area of stem cell therapeutics.
Inventors: Drmanac, Radoje T. (Palo Alto, CA); Labat, Ivan (Mountain View, CA); Tang, Y. Tom (San Jose, CA); Chao, Cheng-Chi (Cupertino, CA); Mize, Nancy K. (Mountain View, CA); Childs, John (Sunnyvale, CA)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Friday January 21st, 2000
Methods for regulating the specific lineages of cells produced in a human hematopoietic cell culture, methods for assaying the effect of substances on lineage-specific cell production, and cell compositions produced by these cultures
Patent Number: 6667034This patent covers ways of ex vivo stimulation of bone marrow and other hematopoietic cells so that after transplantation they may engraft faster. Some of the methods thought in the patent include ways of stimulating production of specific blood cell lineages that may be more important for the specific condition being treated by hematopoietic stem cell transplantation.
Inventors: Palsson, Bernhard O. (La Jolla, CA); Armstrong, R. Douglas (Ann Arbor, MI); Clarke, Michael F. (Ann Arbor, MI); Emerson, Stephen G. (Ann Arbor, MI)
Assignee: The Regents of the University of Michigan (Ann Arbor, MI)
Date of First Priority Issue: Thursday June 15th, 1989
Method and device stimulating the activity of hair follicles
Patent Number: 6666878This patent provides various frequencies of light, and ways of administering light so as to stimulate proliferation and differentiation of the stem cell that is responsible for hair growth. It will be interesting to see if these methods and devices provided can also stimulate other types of stem cells. The use of light may also be beneficial for stimulating proliferation of cancer stem cells...
Inventor: Carlgren, Stefan (Stockholm, SE)
Assignee: Inca Asset Management S.A. (Geneva, CH)
Date of First Priority Issue: Wednesday June 6th, 2001
Methods and compositions for modulating neurodegeneration
Patent Number: 6664039This patent provides a peptide sequence composition of matter that is useful for treatment of neurodegeneration, in part through the stimulation of neural stem cell proliferation. Agents involved in stimulation of neural stem cells are important not only for obvious reasons, but also because they may also stimulate hematopoiesis. The specific peptide claimed in this patent is called "very long...
Inventors: Benzer, Seymour (San Marino, CA); Min, Kyung-Tai (Pasadena, CA)
Assignee: California Institute of Technology (Pasadena, CA)
Date of First Priority Issue: Monday December 14th, 1998
Bioprosthetic heart valves
Patent Number: 6660260This patent coves a heart valve that secretes nitric oxide. This patent is useful for treatment of various diseases associated with valvular dysfunction such as aortic insufficiency and mitral stenosis. The roles of nitric oxide in the cardiovascular system range from vasodilation, to inhibition of apoptosis.
Inventor: Rajamannan, Nalini M. (Rochester, MN)
Assignee: Mayo Foundation for Medical Education and Research (Rochester, MN)
Date of First Priority Issue: Tuesday September 21st, 1999