Patents
Human CNS cell lines and methods of use therefor
Patent Number: 6713247This patent covers neuronal cell and neuronal stem cell lines that are conditionally immortal. These may be used for therapeutic purposes, and also for in vitro drug discovery.
Inventors: Sah, Dinah W. Y. (San Diego, CA); Gage, Fred H. (La Jolla, CA); Ray, Jasodhara (San Diego, CA) )
Assignee: Signal Pharmaceuticials, Inc. (San Diego, CA
Date of First Priority Issue: Tuesday September 3rd, 1996
Methods for storing neural cells such that they are suitable for transplantation
Patent Number: 6713245This patent covers methods of preserving neural stem cells and various types of neuronal cells so that they may be transported for use in treatment of neurological disorders. One of the drawbacks of such cell therapy is the issue of rejection by the allogeneic immune system, this has been addressed in studies using encapsulation, or using stereotactic implantation into the brain, since the...
Inventors: Koopmans, Jan (University of Groningen, NL); Jacoby, Douglas B. (Wellesley, MA); Dinsmore, Jonathan (Brookline, MA)
Assignee: Diacrin, Inc. (Charlestown, MA); University Hospital Groningen (NL)
Date of First Priority Issue: Monday July 6th, 1998
Methods for promoting healing of skin resurfacing wounds
Patent Number: 6713084This patent covers methods of healing skin after a laser wound through the application of stem cells, or various epithelial cells that may be either allogeneic or xenogeneic.
Inventors: Kuri-Harcuch, Walid (Brookline, MA); Bolivar-Flores, Yesid (Delegacion Tlalpan, MX)
Assignee: Celadon Science, LLC (Wellesley, MA)
Date of First Priority Issue: Friday January 17th, 1997
Methods of using hedgehog proteins to modulate hematopoiesis and vascular growth
Patent Number: 6713065This patent covers the use of hedgehog proteins for stimulation of hematopoiesis and angiogenesis. The hedgehog proteins are critically involved in embryogenesis and developmental biology. Given the numerous similarities between stem cells and embryonic cells in general, the notion that hematopoietic stem cells still respond to embryonic signals is intriguing.
Inventors: Baron, Margaret H. (New York, NY); Farrington, Sarah M. (Cambridge, MA); Belaoussoff, Maria (Gottingen, DE)
Assignee: President and Fellows of Harvard College (Cambridge, MA)
Date of First Priority Issue: Monday February 10th, 1997
Method of mobilizing stem cells with chemokine .beta.-8
Patent Number: 6713052This patent teaches ways of mobilizing hematopoietic stem cells using the chemokine know as beta-8. Mobilization may be performed for harvesting of stem cells from peripheral blood by leukopheresis, or it may be performed for the purposes of expanding the number of stem cells in circulation when there is a wound in the body that is attracting stem cells. Such a wound could be the lesion of a...
Inventors: White, John R. (Coatsville, PA); Pelus, Louis (Richboro, PA); Li, Haodong (Germantown, MD); Kreider, Brendt L. (Germantown, MD)
Assignee: Human Genome Sciences, Inc. (Rockville, MD); SmithKline Beecham Corporation (Philadelphia, PA)
Date of First Priority Issue: Tuesday October 24th, 1995
Adipogenic differentiation of human mesenchymal stem cells
Patent Number: 6709864This patent covers the generation of mesenchymal stem cells from adipose tissue. This is an interesting situation since Cytori and others have patents on stem cells from the adipose tissue, and Osiris has patents on mesenchymal stem cells from any tissue. It will be interesting to watch if there is litigation coming out of this patent in light of other patents and clinical trials. For...
Inventors: Pittenger, Mark F. (Severna Park, MD); Beck, Stephen C. (Reistertown, MD)
Assignee: Osiris Therapeutics, Inc. (Baltimore, MD)
Date of First Priority Issue: Tuesday July 30th, 1996
Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures
Patent Number: 6703017This patent covers the treatment of diabetes using islets and/or islet-like cells that are generated from stem cells residing in the pancreatic duct.
Inventors: Peck, Ammon B. (Gainesville, FL); Cornelius, Janet (Gainesville, FL); Ramiya, Vijayakumar K. (Gainesville, FL)
Assignee: Ixion Biotechnology, Inc. (Alachua, FL); University of Florida (Gainesville, FL)
Date of First Priority Issue: Thursday April 28th, 1994
Injectable hyaluronic acid derivative with pharmaceuticals/cells
Patent Number: 6699471This patent teaches various forms of hyaloronic acid that may be administered in combination with stem cells for localization and better function of the stem cell. This patent is interesting in light of US patent application # 20060069064 which teaches "Methods for facilitating recovery of functions of endogenous or implanted or transplanted stem cells using hyaluronic acid"
Inventors: Radice, Marco (Modena, IT); Pastorello, Andrea (Abano Terme, IT); Pavesio, Alessandra (Padua, IT); Callegaro, Lanfranco (Thiene, IT)
Assignee: Fidia Advanced Biopolymers, SRL (Abano Terme, IT)
Date of First Priority Issue: Tuesday December 21st, 1999
Processing fetal or neo-natal tissue to produce a scaffold for tissue engineering
Patent Number: 6696074This patent teaches how to make scaffolds that are useful for subsequent seeding with stem cells and generating tissues. The scaffolds seem to be made from decellularized tissues, including fetal and xenogeneic (in some cases) sources.
Inventors: Dai, Jianwu (Boston, MA); Bell, Eugene (Boston, MA); Russakovsky, Vladimir (Boston, MA)
Assignee: TEI Biosciences, Inc. (Boston, MA)
Date of First Priority Issue: Monday December 4th, 2000
Cardiovascular components for transplantation and methods of making thereof
Patent Number: 6695879This patent provides compositions of matter useful for the treatment of cardiac valve dysfunctions. The compositions may be seeded with stem cells, or may be implanted as scaffolds that naturally become cellularized.
Inventor: Bell, Eugene (Boston, MA)
Assignee: TEI Biosciences, Inc. (Boston, MA)
Date of First Priority Issue: Tuesday October 20th, 1998