Patents
Methods for fabricating a filament for use in tissue engineering
Patent Number: 6730252This patent covers generation of filaments that are useful for forming three dimensional scaffolds for tissue engineering using stem cells or precursor cells.
Inventors: Teoh, Swee Hin (Singapore 596504, SG); Hutmacher, Dietmar Werner (Singapore, SG); Tan, Kim Cheng (Singapore 524856, SG); Tam, Kock Fye (Singapore 730659, SG); Zein, Iwan (Singapore 448909, SG)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Wednesday September 20th, 2000
Materials and methods relating to the transfer of nucleic acid into quiescent cells
Patent Number: 6723561The early hematopoietic stem cells are usually non-proliferating, additionally, intermediately developed hematopoietic stem cells treated with stem cell inhibitors such as TGF-beta, also do not proliferate. This causes a problem for gene therapy since most gene therapy vectors require the cells to be proliferating for appropriate transfection. This patent teaches methods of transfecting cells...
Inventors: Russell, Stephen James (Cambridge, GB); Fielding, Adele Kay (Cambridge, GB); Casimir, Colin Maurice (London, GB)
Assignee: Mayo Foundation for Medical Education and Research (Rochester, MN)
Date of First Priority Issue: Thursday September 28th, 1995
Methods and compositions for healing and repair of articular cartilage
Patent Number: 6727224This patent teaches the use of bone morphogenic proteins together with stem cells for repair of articular cartilage injury. In some embodiments the stem cells may be endogenous.
Inventors: Zhang, Renwen (Rutherford, NJ); Peluso, Diane (Marshfield, MA); Morris, Elisabeth (Sherborn, MA)
Assignee: Genetics Institute, LLC. (Cambridge, MA)
Date of First Priority Issue: Monday February 1st, 1999
Bone resorption inhibitors
Patent Number: 6723696This patent covers a novel factor that on the one hand is involved in leukocyte activation, and on the other hand inhibits bone resorption. This factor is useful in conjunction with stem cell therapies that stimulate bone formation.
Inventors: Suzuki, Kazuo (Misaki-machi, JP); Yamagoe, Satoshi (Kashiwa, JP); Yamakawa, Tooru (Tokyo, JP)
Assignee: Japan as represented by Secretary of National Institute of Infectious Diseases (Tokyo, JP)
Date of First Priority Issue: Tuesday December 22nd, 1998
Methods and compositions for treating intervertebral disc degeneration
Patent Number: 6723335This patent covers the use of a fluid matrix together with stem cells, specifically mesenchymal stem cells, for the regeneration of the nucleus pulposus. This invention is suitable for treatment of patients with lower back pain due to disc degeneration.
Inventors: Moehlenbruck, Jeffrey William (Austin, TX); Ranieri, John Paul (Austin, TX)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Friday April 7th, 2000
Composite bone marrow graft material with method and kit
Patent Number: 6723131This patent teaches how to administer bone marrow in vivo, so that administration is performed not only of hematopoietic stem cells, but also stromal elements. This combination should be useful in patients whose stroma has been destroyed for one reason or another. The invention may also be useful for prevention of donor-derived leukemic relapse.
Inventor: Muschler, George F. (Cleveland Heights, OH)
Assignee: The Cleveland Clinic Foundation (Cleveland, OH)
Date of First Priority Issue: Saturday April 28th, 2001
Nicotine receptor agonists in stem cell and progenitor cell recruitment
Patent Number: 6720340This patent teaches that nicotine may be used for mobilization of stem cells. It covers endothelial precursor cells as well.
Inventors: Cooke, John (Palo Alto, CA); Johnson, Frances Lauri (Portola Valley, CA); Pathak, Anjali (Campbell, CA); Jang, James (San Bruno, CA); Tsao, Phillip (San Jose, CA); Heeschen, Christopher (Menlo Park, CA)
Assignee: The Board of Trustees of the Leland Stanford, Jr. Unversity (Palo Alto, CA)
Date of First Priority Issue: Wednesday July 28th, 1999
Method of generating cartilage
Patent Number: 6719970This patent discloses chondrocytes and suitable biocompatible polymers that may be administered in vivo for the regeneration, or de novo generation of cartilage tissue.
Inventors: Costantino, Henry R. (Grantham, NH); Bonassar, Lawrence J. (Acton, MA); Tracy, Mark A. (Arlington, MA)
Assignee: Alkermes Controlled Therapeutics, Inc. (Cambridge, MA); University of Massachusetts (Boston, MA)
Date of First Priority Issue: Monday July 10th, 2000
Treatment of liver disease and injury with CXC chemokines
Patent Number: 6719969This patent teaches that CXC chemokines are potent stimulators of hepatic stem cells and hepatic regeneration. Chemokines covered include MIP-2, ENA-78 and IL-8.
Inventors: Hogaboam, Cory M. (Ann Arbor, MI); Bone-Larson, Cynthia L. (Petersburg, MI); Simpson, Kenneth J. (Edinburgh, GB); Lukacs, Nicholas W. (Brighton, MI); Kunkel, Steven L. (Ann Arbor, MI); Colletti, Lisa M. (Webberville, MI); Strieter, Robert M. (Sherman Oaks
Assignee: The Regents of The University of Michigan (Ann Arbor, MI); University Court of The University of Edinburgh (GB)
Date of First Priority Issue: Monday August 9th, 1999
2 Comments
2 Comments
Devices and methods for treating tissue
Patent Number: 6719805This patent seems to cover the use of angiogenic stimuli, together with stem cells for treatment of muscle disorders including disorders associated with the myocardium. This patent may influence the current trials ongoing for treatment of myocardial dysfunction with stem cells and angiogenic stimuli.
Inventor: Ahern, John E. (Melrose, MA)
Assignee: C. R. Bard, Inc. (Murray Hill, NJ)
Date of First Priority Issue: Wednesday June 9th, 1999