Patents
Methods and devices for the long-term culture of hematopoietic progenitor cells
Patent Number: 6645489This patent covers ways for the in vivo culture and expansion of hematopoietic stem cells. The advantage of expanding such hematopoietic stem cells in vivo is that they are subjected to more "biological" conditions and at least theoretically should work better than other in vitro systems.
Inventors: Pykett, Mark J. (Boxford, MA); Rosenzweig, Michael (Boston, MA); Kaplan, Richard B. (Beverly Hills, CA)
Assignee: Cytomatrix, LLC (Woburn, MA)
Date of First Priority Issue: Thursday September 25th, 1997
Isoprenoid pathway inhibitors for stimulating bone growth
Patent Number: 6642216This patent covers inhibitors of the isoprenoid pathway which can be used for stimulation of osteoblast and other bone stem cells in order to stimulate growth of bone.
Inventors: Gasper, Shirley R. (Seattle, WA); West, Robert R. (Seattle, WA); Martinez, Theresa (Greenback, WA); Robbins, Kirk G. (Renton, WA); McKernan, Patricia A. (Woodinville, WA); Baindur, Nand (Edmonds, WA); Labroo, Virender M. (Bangalore, IN); Mundy, Gregory R.
Assignee: ZymoGenetics Corporation (Seattle, WA); OsteoScreen, Inc. (San Antonio, TX)
Date of First Priority Issue: Friday December 13th, 1996
Human brain endothelial cells and growth medium and method for expansion of primitive CD34+CD38-bone marrow stem cells
Patent Number: 6642049This patent covers culture techniques and cells that are useful for the growth and expansion of primitive hematopoietic stem cells. One of the interesting aspects of this patent is that it uses human endothelial cells that are derived from the brain as feeder cells. Given all of the interesting correlations between brain cells and bone marrow hematopoietic stem cells, this patent is particularly...
Inventors: Chute, John P. (San Francisco, CA); Saini, Abha A. (Collegeville, PA); Chute, Dennis J. (Los Angeles, CA); Davis, Thomas A. (Newton, PA)
Assignee: The United States of America as represented by the Secretary of the Navy
Date of First Priority Issue: Friday December 4th, 1998
Conditioned media for propagating human pluripotent stem cells
Patent Number: 6642048This patent is part of Geron's armamentarium of patents covering not only embryonic stem cells (licensed from WARF), but also ways of growing them in absence of undefined materials. In this particular patent feeder-free culture methods for maintaining embryonic stem cells, as well as "pluripotent stem cells" are covered.
Inventors: Xu, Chunhui (Cupertino, CA); Gold, Joseph D. (San Francisco, CA)
Assignee: Geron Corporation (Menlo Park, CA)
Date of First Priority Issue: Tuesday January 11th, 2000
Platform for the differentiation of cells
Patent Number: 6638765This patent covers methods of dedifferentiating cells, and redifferentiating them in order to produce islet-like cells for the treatment of diabetes.
Inventor: Rosenberg, Lawrence (Cote St-Luc, CA)
Assignee: McGill University (Montreal, CA)
Date of First Priority Issue: Thursday February 4th, 1999
Isolated mammalian neural stem cells, methods of making such cells
Patent Number: 6638763This patent covers a specific type of early neuronal stem cell that is viable for a sigificant period of time after the host dies. These cells are transplantable and possess some properties of other neural stem cells, however in the patent, unique phenotypic and functional characteristics are provided.
Inventors: Steindler, Dennis A. (Memphis, TN); Laywell, Eric D. (Memphis, TN); Kukekou, Valery G. (Memphis, TN); Thomas, L. Brannon (Johnson City, TN)
Assignee: University of Tennessee Research Foundation
Date of First Priority Issue: Tuesday January 7th, 1997
Use of multipotent neural stem cell progeny to augment non-neural tissues
Patent Number: 6638501This patent covers the use of neural stem cells for enhancing activity of hematopoietic stem cells. This patent attests to the similarity, if not synergy, between the neural stem cell system and the hematopoietic stem cells system.
Inventors: Bjornson, Christopher R. (Calgary, CA); Rietze, Rod L. (Calgary, CA); Reynolds, Brent A. (Saltspring, CA); Vescovi, Angelo L. (Milan, IT)
Assignee: Neurospheres Holdings Ltd. (Alberta, CA)
Date of First Priority Issue: Friday June 19th, 1998
Cell-culture and polymer constructs
Patent Number: 6637437This patent provides novel cellular "fillers" that are generated in culture specifically for the patient, and administered during head and neck surgery in order to "fill the gap".
Inventors: Hungerford, David S. (Cockeysville, MD); Frondoza, Carmelita G. (Woodstock, MD); Shikani, Alan H. (Ruxton, MD); Domb, Abraham J. (Efrat, IL)
Assignee: Johns Hopkins University (Baltimore, MD); Chondros, Inc. (Baltimore, MD)
Date of First Priority Issue: Wednesday April 8th, 1998
Nuclear transfer using cells cultured in serum starvation media containing apoptosis inhibitors
Patent Number: 6635802This patent teaches the use of antiapoptotic agents, and serum starvation, of the recipient cells for nuclear transfer. This can be used to generate autologous embryonic stem cells.
Inventors: Piedrahita, Jorge A. (College Station, TX); Lee, Chang-Kyu (Suwon, KR); Weaks, Regina (Richardson, TX); Bazer, Fuller (College Station, TX)
Assignee: The Texas A&M University System (College Station, TX)
Date of First Priority Issue: Friday October 10th, 1997
Normothermic, hypothermic and cryopreservation maintenance and storage of cells, tissues and organs in gel-based media
Patent Number: 6632666This patent provides novel cellular and tissue storage compositions that are useful for not only stem cells but other cellular therapies.
Inventors: Baust, John M. (Vestal, NY); Van Buskirk, Robert (Apalachin, NY); Baust, John G. (Candor, NY)
Assignee: BioLife Solutions, Inc. (Binghamton, NY)
Date of First Priority Issue: Friday January 14th, 2000