Patents
Compositions for identification and isolation of stem cells
Patent Number: 6632620This patent provides an antibody that recognizes both epidermal stem cells, as well as prostate cancer cells.
Inventor: Makarovskiy, Andrew N. (Mendon, MA)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Thursday June 22nd, 2000
Human FLTS3 ligand
Patent Number: 6632424This patent is part of Immunex's wall of IP surrounding the stem cell stimulatory cytokine flt3 ligand.
Inventors: Lyman, Stewart D. (Seattle, WA); Beckmann, Patricia M. (Poulsbo, WA)
Assignee: Immunex Corporation (Seattle, WA)
Date of First Priority Issue: Monday May 24th, 1993
G-CSF mimetics
Patent Number: 6630470G-CSF has many properties associated with stimulation of stem cells. In this patent compositions of matter for mimetics of G-CSF are provided. This patent can be used for treatment of neutropenia and other conditions that G-CSF is currently used for.
Inventors: Luengo, Juan I (Audubon, PA); Duffy, Kevin J (Norristown, PA)
Assignee: SmithKline Beecham Corporation (Philadelphia, PA)
Date of First Priority Issue: Friday May 22nd, 1998
Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
Patent Number: 6630457This patent teaches new compositions of matter based on hyaluronic acid that are useful for the administration of stem cells.
Inventors: Aeschlimann, Daniel (Madison, WI); Bulpitt, Paul (Madison, WI)
Assignee: Orthogene LLC (Sausalito, CA)
Date of First Priority Issue: Friday September 18th, 1998
Trophoblast cell preparations
Patent Number: 6630349This patent provides trophoblast cell lines that are of murine origin. Since the trophoblast is similar to cancer cells in terms of immune suppression and metastizing ability, this patent is useful for the generation of a xenogeneic cancer vaccine, similar to XenoVax. The fact that trophoblast stem cells are provided is useful since this can be a good off the shelf starting population for...
Inventors: Rossant, Janet (Toronto, CA); Tanaka, Satoshi (Tokyo, JP); Kunath, Tilo (Toronto, CA)
Assignee: Mount Sinai Hospital (Toronto, CA)
Date of First Priority Issue: Wednesday September 23rd, 1998
Method of isolating stem cells
Patent Number: 6627759This patent provides ways of extracting stem cells based on their expression of aldehyde dehydrogenase. This patent is in clinical trials by the company Aldegen.
Inventors: Smith, Clayton A. (Tampa, FL); Colvin, Michael (Chapel Hill, NC); Storms, Robert W. (Durham, NC); Ludeman, Susan M. (Durham, NC)
Assignee: Duke University (Durham, NC)
Date of First Priority Issue: Thursday December 17th, 1998
Anti-transforming growth factor Beta (TGF-.beta.) treated stem cell composition and method
Patent Number: 6627191This patent teaches the use of antibodies to TGF beta in order to stimulate hematopoietic stem cell renewal. Hematopoietic stem cells generation secrete autocrine TGF beta which inhibits their proliferation. This patent inhibits the inhibitor thus attaining stem cell expansion.
Inventors: Bartelmez, Stephen H. (Seattle, WA); Sitnicka, Ewa (Lund, SE); Ruscetti, Frank (New Market, MD)
Assignee: Seattle Biomedical Research Institute (Seattle, WA)
Date of First Priority Issue: Monday January 25th, 1999
Methods for treatment of vascular disease and device for preparation of an autologous composition for treating vascular disease
Patent Number: 6623733While some patents use cell supernatant for induction of biological activities, this patent goes all out and uses cell lysates! This patent covers the use of various cell lysates, including of stem cells, in order to augment stem cell proliferation as well as angiogenesis.
Inventors: Hossainy, Syed F. A. (Fremont, CA); Steward, Jeffrey A. (Lakewood, CO); Consigny, Paul M. (Sunnyvale, CA) )
Assignee: Advanced Cardiovascular Systems, Inc. (Santa Clara, CA)
Date of First Priority Issue: Wednesday June 27th, 2001
Hematopoietic differentiation of human embryonic stem cells
Patent Number: 6613568This patent teaches the generation of human hematopoietic stem cells from human embryonic stem cells by the simple culture of the embryonic stem cells on human bone amrrow stromal cells.
Inventors: Kaufman, Dan S. (Madison, WI); Thomson, James A. (Madison, WI)
Assignee: Wisconsin Alumni Research Foundation (Madison, WI)
Date of First Priority Issue: Monday November 8th, 1999
Use of delta-like protein to inhibit the differentiation of stem cells
Patent Number: 6613565This patent covers the inhibition of hematopoietic stem cell differentiation through administration of the protein called "delta-like protein" (dlk). The patent teaches not only the use for expansion, but also for protecting the stem cell compartment from the effects of chemotherapy or radiotherapy.
Inventors: Witte, Larry (Stormville, NY); Pytowski, Bronislaw (New York, NY); Moore, Kateri A. (Princeton, NJ); Lemischka, Ihor R. (Princeton, NJ)
Assignee: ImClone Systems Incorporated (New York, NY); Trustees of Princeton University (Princeton, NJ)
Date of First Priority Issue: Friday March 1st, 1996