Patents
Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood
Patent Number: 6605275This patent covers preservation of cord blood cells. It is one of the patents that is actually generating revenue and has stood the test of litigation. Anyone doing cord blood banking in the US has to license this patent.
Inventors: Boyse, Edward A. (Tucson, AZ); Broxmeyer, Hal E. (Indianapolis, IN); Douglas, Gordon W. (New York, NY)
Assignee: PharmaStem Therapeutics, Inc. (Wayne, PA)
Date of First Priority Issue: Thursday November 12th, 1987
Method of making embryoid bodies from primate embryonic stem cells
Patent Number: 6602711This is a patent for forming what is called "embryoid bodies" which are cellular aggregated generated from embryonic stem cells. Embryoid bodies can be subsequently dissociated in order to form various histological tissues useful for regenerative purposes.
Inventors: Thomson, James A (Madison, WI); Marshall, Vivienne S. (Madison, WI); Swiergiel, Jennifer J. (Roscoe, IL)
Assignee: Wisconsin Alumni Research Foundation (Madison, WI)
Date of First Priority Issue: Monday February 21st, 2000
Production of gabaergic cells
Patent Number: 6602680This patent teaches that transfection of neuronal stem cells with dlx induces their differentiation into neurons that express GABA. This is useful for generation of cell therapies of neurodegenerative diseases.
Inventors: Rubenstein, John L. (San Francisco, CA); Mione, Marina (London, GB); Anderson, Stewart (San Francisco, CA); Stuehmer, Thorsten (San Francisco, CA); Yun, Kyuson (San Francisco, CA)
Assignee: The Regents of the University of California (Oakland, CA)
Date of First Priority Issue: Friday July 14th, 2000
Method of inducing new bone growth in porous bone sites
Patent Number: 6599520This patent provides matrices that are useful for treatment of bone disorders. The matrices may be seeded with stem cells to accelerate regeneration of bone.
Inventors: Scarborough, Nelson L. (Andover, MA); Russell, James (Little Silver, NJ)
Assignee: Osteotech, Inc. (Eatontown, NJ)
Date of First Priority Issue: Friday October 13th, 2000
Cell delivery catheter and method
Patent Number: 6599274This patent provides a medical device that can be utilized for administration of stem cells to localized areas of need using a catheter-based system.
Inventors: Kucharczyk, John (Bishop, GA); Gillies, George T., N/A (Charlottesville, VA); Broaddus, William C., Fillmore, Helen L.
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Saturday January 1st, 2000
Vasostatin as marrow protectant
Patent Number: 6596690This patent covers the new use of vasostatin in inhibiting the killing of stem cells from agents that are cytotoxic the mitotic cells such as radiation and chemotherapy.
Inventors: Tosato, Giovanna (Bethesda, MD); Pike, Sandra E. (North Bethesda, MD); Yao, Lei (Rockville, MD)
Assignee: The United States of America as represented by the Department of Health and Human Services
Date of First Priority Issue: Tuesday October 6th, 1998
Method for promoting hematopoiesis
Patent Number: 6596688This patent teaches that administration of the pregnancy associated compound human chorionic gonadotropin can stimulate hematopoietic stem cells. This patent is interesting in light of clinical trials that are ongoing by Stem Cell Therapeutics Inc that use hCG in combination with other compounds for post-stroke regeneration of neurons.
Inventors: Gallo, Robert C. (Bethesda, MD); Bryant, Joseph (Rockville, MD); Lunardi-Iskandar, Yanto (Gaithersburg, MD)
Assignee: University of Maryland Biotechnology Institute (Baltimore, MD)
Date of First Priority Issue: Monday September 9th, 1996
Biological material containing bone marrow stem cells partially or completely differentiated into connective tissue cells and a hyaluronic acid ester matrix
Patent Number: 6596274This patent provides materials that are biologically compatible, combined with bone marrow stem cells and/or progeny, for regenerative uses.
Inventors: Abatangelo, Giovanni (Saccolongo, IT); Callegaro, Lanfranco (Thiene, IT)
Assignee: Fidia Advanced Biopolymers S.r.l. (Brindisi, IT)
Date of First Priority Issue: Monday November 20th, 1995
Methods and compositions to improve germ cell and embryo survival and function
Patent Number: 6593309This patent provides methods of increasing viability of cells used for the generation of embryonic stem cells. The patent is also useful for in vitro fertilization, where viability of oocytes is an issue.
Inventors: Ellington, Joanna E. (Valleyford, WA); Oliver, Sylvia Adams (Spokane, WA)
Assignee: Bio-Origyn LLC (Spokane, WA
Date of First Priority Issue: Thursday October 19th, 1995
Treatment of inner ear hair cells
Patent Number: 6593290This patent teaches that IGF-1 and/or FGF-2 are useful for the stimulation of ear hair stem cell expansion. This invention may be used for preventing hearing loss. FGF2 is approved in Japan for certain indications, including some associated with the ear.
Inventor: Gao, Wei-Qiang (Foster City, CA)
Assignee: Genentech, Inc. (South San Francisco, CA)
Date of First Priority Issue: Friday November 1st, 1996