Patents
Method of promoting chondrocyte differentiation with hedgehog related polypeptides
Patent Number: 6610656This patent teaches the use of hedgehog proteins for inducing stem cells to differentiate into the chondocytic lineage (useful for repairing of cartilage).
Inventors: Ingham, Philip W. (Summertown, GB); McMahon, Andrew P. (Lexington, MA); Tabin, Clifford J. (Cambridge, MA)
Assignee: President and Fellows of Harvard College (Cambridge, MA); Imperial Cancer Research Technology, Ltd. (London, GB)
Date of First Priority Issue: Thursday December 30th, 1993
Inhibitor of stem cell proliferation and uses thereof
Patent Number: 6610654This patent provides peptides that inhibit stem cell proliferation, specific inhibition of hematopoietic stem cell proliferation is covered. These peptides are originally derived from bone marrow, but here are generated synthetically. They are useful for protection of the bone marrow stem cell compartment from agents that kill mitotically active cells.
Inventors: Tsyrlova, Irena (Gaithersburg, MD); Wolfe, Stephen D. (Rockville, MD)
Assignee: Wellstat Therapeutics Corporation (Gaithersburg, MD)
Date of First Priority Issue: Wednesday March 31st, 1993
Molecules that home to various selected organs or tissues
Patent Number: 6610651This patent covers peptides that specifically home to the lung. This patent is useful for delivering compounds that activate pulmonary stem cells to the lung. Since injected stem cells generally go to the lung, the administration of stem cell factors targeted to the lung using these peptides in combination with exogenous stem cells may be a new therapeutic approach.
Inventors: Ruoslahti, Erkki (Rancho Santa Fe, CA); Pasqualini, Renata (Solana Beach, CA)
Assignee: The Burnham Institute (La Jolla, CA)
Date of First Priority Issue: Friday March 13th, 1998
Low oxygen culturing of central nervous system progenitor cells
Patent Number: 6610540This patent teaches that low oxygen conditions may be used in the expansion and differentiation of undifferentiated mesencephalic stem cells. This is interesting since in the hematopoietic system the early stem cells also prefer growth in the relatively hypoxic niches of the marrow.
Inventors: Csete, Marie (Ann Arbor, MI); Doyle, John (South Pasadena, CA); Wold, Barbara J. (San Marino, CA); McKay, Ron (Bethesda, MD); Studer, Lorenz (New York, NY)
Assignee: California Institute of Technology (Pasadena, CA); National Institutes of Health (Bethesda, MD)
Date of First Priority Issue: Wednesday November 18th, 1998
Reconstructed laminae of human epithelium corneae and method of producing the same
Patent Number: 6610538This patent teaches how to generate corneal epithelium in vitro from stem cell sources.
Inventors: De Luca, Michele (Ardea, IT); Pellegrini, Graziella (Ardea, IT)
Assignee: Provincia Italiana Della Congregazione Dei Figli Dell' Immacolata Concezione - Istituto Dermopatico Dell' Immacolata (Rome, IT)
Date of First Priority Issue: Tuesday September 25th, 2001
Progenitor cells and methods and uses related thereto
Patent Number: 6610535This patent teaches the generation of islet like cells from pancreatic stem cells. It is useful for the treatment of diabetes. One source of stem cells used in this patent is pancreatic duct stem cells.
Inventors: Lu, Kuanghui (Brookline, MA); Pang, Kevin (Canton, MA); Rubin, Lee (Wellesley, MA)
Assignee: ES Cell International Pte Ltd. (SG)
Date of First Priority Issue: Thursday February 10th, 2000
Cytokine-like proteins that promote cell proliferation
Patent Number: 6610285This patent covers a composition of matter that is a little similar to G-CSF in structure. The composition is useful for expansion of hematopoietic stem cells and several other types of cells.
Inventor: Hirata, Yuichi (Niihari-mura, JP)
Assignee: Chugai Seiyaku Kabushiki Kaisha (Tokyo, JP)
Date of First Priority Issue: Tuesday April 14th, 1998
Vertebrate embryonic pattern-inducing proteins and uses related thereto
Patent Number: 6607913This is a composition of matter patent on molecules associated with embryonic differentiation of the hedgehog family. These molecules can provide a wealth of possibilities in regenerative medicine, especially given that they have receptors in numerous types of embryonic stem cells.
Inventors: Ingham, Philip W. (Summertown, Oxford OX27L, GB); McMahon, Andrew P. (Lexington, MA); Tabin, Clifford J. (Cambridge, MA)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Thursday December 30th, 1993
Genetically altered mammalian embryonic stem cells, their living progeny, and their therapeutic application for improving cardiac function after myocardial infarction
Patent Number: 6607720This patent covers the use of embryonic stem cells as a source of stem cells for myocardial regeneration. Specifically, this patent covers genetically manipulated cells that are useful for these purposes.
Inventors: Xiao, Yong-Fu (Wayland, MA); Morgan, James P. (Newton Centre, MA)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Tuesday September 5th, 2000
Process and apparatus for utilization of in vivo extracted plasma with tissue engineering devices, bioreactors, artificial organs, and cell therapy applications
Patent Number: 6607501This patent teaches ways to continously perfuse a cell culture with plasma from a patient by performing a specialized "in vivo" plasmapheresis.
Inventor: Gorsuch, Reynolds G. (Yountville, CA)
Assignee: Transvivo, Inc. (Napa, CA)
Date of First Priority Issue: Monday May 14th, 2001