Patents
Cell-based gene therapy
Patent Number: 6592864When cells are administered into the lung, many times they get stuck there. This invention takes advantage of this and claims the use of various cells, including stem cells, as vectors for genes that are beneficial for lung function. I believe that this inventor actually performed clinical trials by administration of iNOS transfected fibroblasts into patients with pulmonary hypertension.
Inventor: Stewart, Duncan John (Toronto, Ontario, CA)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Friday March 27th, 1998
Methods for the modulation of the growth of collateral arteries and/or other arteries from preexisting arteriolar connections
Patent Number: 6592862This patent essentially covers the induction of angiogenesis using the chemokine MCP-1. This patent would most likely synergize by combining administration of MCP-1 with hematopoietic stem cells and/or endothelial precursor cells.
Inventors: Schaper, Wolfgang (Bad Nauheim/Rodgen, DE); Ito, Wulf D. (Luneburg, DE)
Assignee: Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V. (Berlin, DE)
Date of First Priority Issue: Friday April 4th, 1997
Cell separation using electric fields
Patent Number: 6589786This patent teaches how to utilize distinct electromagnetic properties of stem cells for their isolation. Additionally it teaches how to purge a population of stem cells from contaminating cancer cells.
Inventors: Mangano, Joseph A. (Vienna, VA); Eppich, Henry M. (Andover, MA)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Thursday September 4th, 1997
Methods for isolation and activation of, and control of differentiation from, stem and progenitor cells
Patent Number: 6589728This patent is directed primarily at muscle stem cells and methods of expanding and isolating them by culturing at low oxygen tension. It seems like muscle stem cells are similar to hematopoietic and neuronal stem cells in the fact that they prefer conditions of low oxygen tension.
Inventors: Csete, Marie (South Pasadena, CA); Doyle, John (South Pasadena, CA); Wold, Barbara (San Marino, CA)
Assignee: California Institute Of Technology (Pasadena, CA)
Date of First Priority Issue: Wednesday November 18th, 1998
Method and device for preparing a dental implant by immersion in a culture of mesenchymal cells
Patent Number: 6589525This patent teaches how to use various cells, including stem cells, for generation of a dental implant.
Inventor: Gault, Philippe (Orleans, FR)
Assignee: Societe Anonyme Natural Implant (Brest, FR)
Date of First Priority Issue: Tuesday October 13th, 1998
System for the in vivo delivery and expression of heterologous genes in the bone marrow
Patent Number: 6583121Gene therapy would greatly benefit from the ability to use stem cells as vectors. This patent addresses the problem of transfecting stem cells through the use of alpha viruses. Some clinical trials are already underway using alpha viruses.
Inventors: Johnston, Robert E. (Chapel Hill, NC); Davis, Nancy L. (Chapel Hill, NC); Simpson, Dennis A. (Chapel Hill, NC)
Assignee: University of North Carolina at Chapel Hill (Chapel Hill, NC)
Date of First Priority Issue: Wednesday February 19th, 1997
Directed maturation of CD34 negative stem cells to programmable antigen presenting cells
Patent Number: 6586243This patent teaches ways of generating dendritic cells from human hematopoietic stem cells and furthermore teaches how to pulse these dendritic cells with tumor antigens for use as cancer vaccines. This approach is similar in some ways to work performed by Eli Gilboa and the company Argos Therapeutics.
Inventors: Cezayirli, Cem (Birmingham, AL); Silvers, Mel (North Miami Beach, FL)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Wednesday July 2nd, 1997
Compositions and methods for use in affecting hematopoietic stem cell populations in mammals
Patent Number: 6586192This patent seems to cover a type of hematopoietic stem cell that is positive for expression of the marker KDR-1.
Inventors: Peschle, Cesare (Rome, IT); Ziegler, Benedikt L. (Tuebingen, DE)
Assignee: Thomas Jefferson University (Philadelphia, PA); Instituto Superiore di Sanita (Rome, IT)
Date of First Priority Issue: Friday May 29th, 1998
Therapeutic polypeptides from .beta.-hCG and derivatives
Patent Number: 6583109This patent covers derivatives of the human chorionic gonadotrophin, as well as hCG itself, for the stimulation of hematopoiesis, reduction of cancer, and reduction of HIV.
Inventors: Gallo, Robert C. (Bethesda, MD); Bryant, Joseph (Rockville, MD); Lunardi-Iskandar, Yanto (Gaithersburg, MD)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Monday September 9th, 1996
Use of fibroblast growth factor 2 for expansion of chondrocytes and tissue engineering
Patent Number: 6582960This patent teaches that FGF-2 can actually de-differentiate certain cells, and be used for the formation of chondrocytes. This would be useful for cartilage repair, as well as for various tissue regenerative purposes.
Inventors: Martin, Ivan (Basel, CH); Freed, Lisa E. (Belmont, MA); Langer, Robert (Newton, MA); Vunjak-Novakovic, Gordana (Belmont, MA)
Assignee: Massachusetts Institute of Technology (Cambridge, MA)
Date of First Priority Issue: Friday September 18th, 1998