Patents
Methods for implanting cells
Patent Number: 6579313The problem with various grafts and prosthesis is that the body starts reacting to them, either through restenosis, or complement activation, or thrombosis. This patent teaches unique ways to generate grafts and prosthetics through the implantation of stem cells and/or other cellular components in the structure to be introduced into the body.
Inventors: Dzau, Victor J. (Newton, MA); Pratt, Richard E. (Newton, MA); Mann, Michael J. (Newton, MA); Ehsan, Afshin (Boston, MA); Griese, Daniel P. (Boston, MA)
Assignee: The Bringham and Women's Hospital (Boston, MA)
Date of First Priority Issue: Friday July 10th, 1998
Method for identification of cell growth or differentiation factors
Patent Number: 6576433This patent teaches the use of HOX11 cell populations for identifying genes that control stem cell proliferation and differentiation.
Inventors: Keller, Gordon M. (Denver, CO); Hawley, Robert G. (Toronto, CA); Choi, Kyunghee (Baltimore, MD)
Assignee: National Jewish Medical & Research Center (Denver, CO)
Date of First Priority Issue: Monday November 21st, 1994
Identification of a G protein-coupled receptor transcriptionally regulated by protein tyrosine kinase signaling in hematopoietic cells
Patent Number: 6569995This patent covers an antibody that binds to GPCR involved in stem cell expansion and differentiation.
Inventors: Weng, Zhigang (Los Angeles, CA); Witte, Owen N. (Sherman Oaks, CA)
Assignee: The Regents of the University of California (Oakland, CA)
Date of First Priority Issue: Thursday November 13th, 1997
Human bone accessory cells
Patent Number: 6576465This patent covers a type of stem cell, or actually a cell that helps bone generating stem cells to perform their function. Therapeutic applications of this cell range from in vitro expansion of bone stem cells, to in vivo induction of bone regeneration.
Inventor: Long, Michael W. (Northville, MI)
Assignee: The Regents of the University of Michigan (Ann Arbor, MI)
Date of First Priority Issue: Monday November 10th, 1997
Methods for providing differentiated stem cells
Patent Number: 6576464It is well known that embryonic stem cells can cause cancers called teratomas. This patent teaches the transfection of embryonic stem cells with suicide genes so that after the embryonic stem cell or its differentiated progeny are introduced into the body, they can be induced to kill themselves after having performed their effects. Of course we all know that cells mutate and even one small...
Inventors: Gold, Joseph D. (San Francisco, CA); Lebkowski, Jane S. (Portola Valley, CA)
Assignee: Geron Corporation (Menlo Park, CA)
Date of First Priority Issue: Monday November 27th, 2000
Electroactive materials for stimulation of biological activity of stem cells
Patent Number: 6569654This patent teaches ways of stimulating virtually all possible biological activities from mesenchymal stem cells through the contact with electroactive materials.
Inventors: Shastri, Venkatram (Lower Gwynedd, PA); Martin, Ivan (Oberwil, CH); Langer, Robert (Newton, MA); Rahman, Nahid (Boston, MA)
Assignee: Massachusetts Institute of Technology (Cambridge, MA)
Date of First Priority Issue: Friday September 18th, 1998
Pharmaceutical products comprising endothelial cell precursors
Patent Number: 6569428This patent provides the endothelial stem cell together with endothelial stem cell activatory genes as a pharmaceutical preparation for the stimulation of angiogenesis. This patent is useful for the treatment of ischemic disorders ranging from angina, to cerebral palsy, to peripheral vascular disease.
Inventors: Isner, Jeffrey M. (Weston, MA); Asahara, Takayuki (Arlington, MA)
Assignee: St. Elizabeth's Medical Center of Boston, Inc. (Boston, MA)
Date of First Priority Issue: Friday November 8th, 1996
Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood
Patent Number: 6569427This patent covers the use of cord blood cells. Any cord blood bank in the US has to license this patent or else Pharmastem will litigate as they have in the past.
Inventors: Boyse, Edward A. (Tucson, AZ); Broxmeyer, Hal E. (Indianapolis, IN); Douglas, Gordon W. (New York, NY)
Assignee: PharmaStem Therapeutics, Inc. (Del Mar, CA)
Date of First Priority Issue: Thursday November 12th, 1987
Methods of inducing nervous tissue regeneration
Patent Number: 6569423This patent teaches how to induce neuronal stimulation and production of new neurons through administration of Schwann cells that express the protein DELTA.SCIP.
Inventor: Weinstein, David E. (Dobbs Ferry, NY)
Assignee: Albert Einstein College of Medicine of Yeshiva University (Bronx, NY)
Date of First Priority Issue: Monday April 19th, 1999
I-Sce I induced gene replacement and gene conversion in embryonic stem cells
Patent Number: 6566579This patent teaches ways of generating knockout mice through a new targeting vector. Alternatively, knockout human embryonic stem cells can be made by this approach for generation of new tissues.
Inventors: Jaisser, Frederic (Malakoff, FR); Cohen-Tannoudji, Michel (Paris, FR); Robine, Sylvie (Vanves, FR); Choulika, Andre (Paris, FR); Louvard, Daniel (Sceaux, FR); Babinet, Charles (Paris, FR)
Assignee: Institut Pasteur (Paris, FR); Institut Curie (Paris, FR); Centre Nationale de la Recherche Scientifique (Paris, FR)
Date of First Priority Issue: Thursday April 18th, 1996