Patents
Patched genes and uses related thereto
Patent Number: 6551782This patent covers ways of identifying expression of the gene patched inside cells. This is important since various stem cells, embryonic tissues, and cancer cells express this gene in its wildtype or mutated form. The manipulation of the patched pathway can be used for stem cell differentiation and/or expansion.
Inventors: Scott, Matthew P. (Stanford, CA); Goodrich, Lisa V. (Palo Alto, CA); Johnson, Ronald L. (Redwood City, CA); Epstein, Jr., Ervin (Orinda, CA)
Assignee: Stanford University (Stanford, CA); University of California (Oakland, CA)
Date of First Priority Issue: Friday October 7th, 1994
Compositions and methods for delivery of agents for neuronal regeneration and survival
Patent Number: 6551618This patent covers a matrix that is embedded with genes that stimulate stem cell expansion and/or differentiation. The matrix can be administered alone or in combination with stem cells.
Inventors: Baird, Andrew (San Diego, CA); Gonzalez, Ana Maria (San Diego, CA); Logan, Ann (Worcester, GB); Berry, Martin (Birmingham, GB)
Assignee: University of Birmingham (Birmingham, GB); King's College (London, GB); Selective Genetics, Inc. (San Diego, CA
Date of First Priority Issue: Tuesday March 15th, 1994
Tissue transplant coated with biocompatible biodegradable polymer
Patent Number: 6551355This patent covers various biocompatible coating compositions that in one embodiment are used to decrease immunogenecity of bone grafts.
Inventors: Lewandrowski, Kai-Uwe (Brookline, MA); Bondre, Shrikar (Malden, MA); Trantolo, Debra J. (Princeton, MA); Cattaneo, Maurice V. (Quincy, MA); Gresser, Joseph D. (Brookline, MA); Wise, Donald L. (Belmont, MA)
Assignee: Cambridge Scientific, Inc. (Cambridge, MA)
Date of First Priority Issue: Friday August 14th, 1998
Method and device for myogenesis and angiogenesis of the heart
Patent Number: 6551338This patent covers ways of entering the myocardium through transthoracic means in order to administer angiogenic stimuli, which may include stem cells, or activators of stem cells that are associated with angiogenesis. The patent also discloses various administration devices.
Inventors: Chiu, Ray Chu-Jeng (Montreal, CA); Lachapelle, Kevin (Westmount, CA)
Assignee: McGill University (Montreal, CA)
Date of First Priority Issue: Wednesday September 1st, 1999
Lymphoid tissue-specific cell production from hematopoietic progenitor cells in three-dimensional devices
Patent Number: 6548299This patent teaches how to generate cells of the lymphoid lineage in vitro through a variety of devices and culture techniques. This patent could be used for generating T suppressor cells in order to antigen-specifically inhibit autoimmunity.
Inventors: Pykett, Mark J. (Newton, MA); Rosenzweig, Michael (Boston, MA); Scadden, David T. (Weston, MA); Poznansky, Mark C. (Charlestown, MA)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Thursday November 12th, 1998
Embryonic germ cells, method for making same, and using the cells to produce a chimeric porcine
Patent Number: 6545199This patent teaches ways of culturing various pluripotent embryonic germ stem cells. Methods are disclosed, as well as specific culture reagents. In one particular embodiment emphasis is placed on embryonic germ cells from pigs.
Inventors: Anderson, Gary B. (Davis, CA); Shim, Hosup (Davis, CA)
Assignee: The Regents of the University of California (Oakland, CA)
Date of First Priority Issue: Tuesday January 9th, 1996
Mediators of hedgehog signaling pathways, compositions and uses related thereto
Patent Number: 6545005This patent provides compositions of matter that target signalling through the hedgehog pathway. This is important for inhibition of cancer cells since in many cases they have constitutive activation of the hedgehog pathway.
Inventors: Baxter, Anthony David (Abingdon, GB); Boyd, Edward Andrew (Didcot, GB); Guicherit, Oivin M. (Belmont, MA); Price, Stephen (Aylesbury, GB); Rubin, Lee D. (Wellesley, MA)
Assignee: Curtis, Inc. (Cambridge, MA)
Date of First Priority Issue: Thursday September 16th, 1999
Non-myeloablative/lymphoablative conditioning regimen to induce patient anti-donor unresponsiveness in stem cell transplantation
Patent Number: 6544787This patent provides methods of performing hematopoietic transplants without having to wipe out the recipient's myelopoietic system. Specifically the patent teaches ways of inducing tolerance. This can be used not only for stem cell transplants, but also to induce donor-specific tolerance in a variety of solid organ transplant settings.
Inventor: Slavin, Shimon (Jerusalem, IL)
Assignee: Hadash Medical Research Services and Development Ltd. (Jerusalem, IL); Baxter International Inc. (Deerfield, IL)
Date of First Priority Issue: Friday November 15th, 1996
Pancreatic progenitor 1 gene and its uses
Patent Number: 6541251This patent teaches ways of identifying pancreatic stem cells by assessing expression of the gene which encodes pancreatic progenitor-1.
Inventors: Sarvetnick, Nora (San Diego, CA); Fox, Howard (San Diego, CA)
Assignee: The Scripps Research Institute (La Jolla, CA)
Date of First Priority Issue: Thursday April 26th, 2001
Cell seeding of ceramic compositions
Patent Number: 6544290This patent provides cell scaffolds made of a variety of materials, including ceramic. These scaffolds are useful for the growth of various tissues both in vitro and in vivo.
Inventors: Lee, Dosuk D. (Brookline, MA); Rey, Christian (Castanet, FR); Aiolova, Maria (Brookline, MA)
Assignee: Etex Corporation (Cambridge, MA)
Date of First Priority Issue: Friday May 19th, 1995