Patents
Derivation of pluripotential embryonic cell lines from ungulate species
Patent Number: 6436701This patent covers methods of generating stem cells, embryonic stem cells from ungulate species. This technology may be useful not only for veterinary applications, but also for generating large quantities of cytoplasm with "dedifferentiating" ability that may be used for various regenerative purposes in humans...many of the cytoplasmic factors in embryonic stem cells that induce...
Inventors: Evans, Martin John (Cambridge, GB); Moor, Robert Michael (Babraham, GB); Notaranni, Elena (Cambridge, GB)
Assignee: Babraham Institute (Cambridge, GB)
Date of First Priority Issue: Monday September 12th, 1988
Methods of ex-vivo expansion of hematopoietic cells using multivariant IL-3 hematopoiesis chimera proteins
Patent Number: 6436387This patent covers chimeric proteins that are based on the cytokine interleukin-3. The specific use of these proteins for expanding stem cells of the hematopoeitic lineage outside the body are disclosed.
Inventors: Bauer, S. Christopher (New Haven, MO); Abrams, Mark Allen (St. Louis, MO); Braford-Goldberg, Sarah Ruth (St. Louis, MO); Caparon, Maire Helena (Chesterfield, MO); Easton, Alan Michael (Maryland Heights, MO); Klein, Barbara Kure (St. Louis, MO); McKearn, J
Assignee: G.D. Searle & Co. (Chicago, IL)
Date of First Priority Issue: Tuesday November 24th, 1992
Autogenous cell patch cardio myoplasty and advanced muscle graft implantation system
Patent Number: 6435190This patent teaches what appears to be a surgical method for producing an autograft that can cover lesions in the heart. This is important since after a heart attack, there is scar tissue formation, and the heart starts to lose function. The patent also covers ways in which autologous stem cells may be administered.
Inventors: Taheri, Syde A. (Buffalo, NY); Leonhardt, Howard J. (Weston, FL)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Wednesday June 14th, 2000
Inhibitor of stem cell proliferation and uses thereof
Patent Number: 6432917This patent covers a strange composition generated from bone marrow by various chemical and physical procedures that seems to inhibit leukemic stem cell proliferation. This patent is similar to a composition published previously called Reptimed that was also bone marrow derived and inhibited leukemic cell activity.
Inventors: Kozlov, Vladimir (Novosibirisk, RU); Tsyrlova, Irena (Gaithersburg, MD)
Assignee: Pro-Neuron, Inc. (Gaithersburg, MD)
Date of First Priority Issue: Wednesday March 31st, 1993
Embryonic stem cells capable of differentiating into desired cell lines
Patent Number: 6432711This patent covers the generation of neurons and muscle cells from embryonic stem cells. The patent uses fetal calf serum which can be a drawback to clinical implimentation.
Inventors: Dinsmore, Jonathan H. (Brookline, MA); Ratliff, Judson (Stoneham, MA)
Assignee: Diacrin, Inc. (Charlestown, MA)
Date of First Priority Issue: Wednesday November 3rd, 1993
Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair
Patent Number: 6429013This patent teaches how to generate cartilage and chondrocytes from stromal cells that are derived from adipose tissues. Another company working heavily in this area is Cytori, formerly called Macropore.
Inventors: Halvorsen, Yuan-Di C. (Holly Springs, NC); Wilkison, William O. (Bahama, NC); Gimble, Jeffrey Martin (Chapel Hill, NC)
Assignee: Artecel Science, Inc. (Durham, NC)
Date of First Priority Issue: Thursday August 19th, 1999
Cell population containing non-fetal hemangioblasts and method for producing same
Patent Number: 6429012This is a patent for a cell population that can differentiate into both the hematopoietic lineage and the endothelial lineage.
Inventors: Kraus, Morey (Worcester, MA); Wilder, Paul (Worcester, MA)
Assignee: Viacell, Inc. (Worcester, MA)
Date of First Priority Issue: Tuesday June 10th, 1997
Method of inducing formation of kidney epithelia from mesenchymal precursors
Patent Number: 6423681This patent teaches how to induce formation of new kidney cells in vivo through the administration of ligands of gp130 such as LIF. This is one of the few patents that covers administration of therapies systemically that induce generation of new cells by stimulation of endogenous stem cells. This patent is in line with the approach of Transition Therapeutics for generation of new islets, and...
Inventors: Barasch, Jonathan M. (New York, NY); Oliver, Juan A. (New York, NY); Yang, Jun (New York, NY)
Assignee: The Trustees of Columbia University in the City of New York (New York, NY)
Date of First Priority Issue: Tuesday May 4th, 1999
Human pluripotent hematopoietic colony stimulating factor, method of use
Patent Number: 6419918This patent covers the pluripotent colony stimulating factor, a type of cytokine that is not really described in terms of modern nomenclature in this patent. The use of such stem cell stimulatory cytokines that come from the hematopoietic system should be explored for other types of stem cells...this is especially since there is so much similarity between stem cells of various tissues not...
Inventors: Welte, Karl (New York, NY); Platzer, Erich (Spardorf, DE); Gabrilove, Janice L. (New York, NY); Mertelsman, Roland (Mainz, DE); Moore, Malcolm A. S. (Larchmont, NY)
Assignee: Sloan-Kettering Institute for Cancer Research (New York, NY)
Date of First Priority Issue: Thursday March 28th, 1985
Phosphatidylinositol 3-kinase inhibitors as stimulators of endocrine differentiation
Patent Number: 6413773This patent teaches that if one inhibits the PI3 kinase pathway, it is possible to induce differentiation of pancreatic stem cells into islet-like cells. PI3k has activity in a variety of stem cells, including hematopoietic stem cells. It will be interesting to see what modification of this enzyme does in other types of stem cells.
Inventors: Ptasznik, Andrezej (Philadelphia, PA); Hayek, Alberti (La Jolla, CA); Beattie, Gillian M. (Poway, CA)
Assignee: The Regents of the University of California (Oakland, CA)
Date of First Priority Issue: Monday June 1st, 1998