Patents
Hypoxia mediated neurogenesis
Patent Number: 6368854Bone marrow stem cells and other types of stem cells prefer to reside in conditions of hypoxia. In this patent, the use of hypoxia for inducing differentiation of neural stem cells into neurons is disclosed.
Inventors: Weiss, Samuel (Calgary, CA); Sorokan, S. Todd (Victoria, CA) )
Assignee: NeuroSpheres Holdings Ltd. (Calgary, CA
Date of First Priority Issue: Friday October 24th, 1997
Mesenchymal stem cells for prevention and treatment of immune responses in transplantation
Patent Number: 6368636This patent teaches the use of mesenchymal stem cells for preventing allograft rejection through immune modulation. It is known that bone marrow cells can display a veto-like effect in that they are capable of inducing donor-specific tolerance. The bone marrow cells are one source of mesenchymal stem cells. In this patent purified mesenchymal stem cells are claimed not only for inducing...
Inventors: McIntosh, Kevin R. (Ellicott City, MD); Mosca, Joseph D. (Ellicott City, MD); Klyushnenkova, Elena N. (Baltimore, MD)
Assignee: Osiris Therapeutics, Inc. (Baltimore, MD)
Date of First Priority Issue: Wednesday March 18th, 1998
Devices for cloaking transplanted cells
Patent Number: 6368612This patent covers a device that can be implanted so as to protect the cells inside the device from immune mediated rejection. This is particularly useful for stem cell therapy and therapy with cells that are differentiated from stem cells because it would allow for the use of one cell source in all people. The device is also useful for transplantation of islet cells that are xenogeneic to the...
Inventors: Lanza, Robert P. (Clinton, MA); Chick, William (Wellesley, MA)
Assignee: Biohybrid Technologies LLC (Shrewsbury, MA)
Date of First Priority Issue: Friday December 12th, 1997
Hematopoietic cell method for treatment of HIV infection
Patent Number: 6365404This patent teaches the treatment of HIV by reconstituting the immuen system with cells that can not be infected since they lack the HIV receptor or co-receptor. This patent is neat since theoretically it would not need immune suppression since the HIV will perform the task of selecting only for the cells that are resistant...then again the HIV may mutate !!
Inventor: O'Donnell, Jr., Francis E. (St. Louis, MO)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Monday August 12th, 1996
Mechanically elongated neuronal cells and methods for producing and using these cells
Patent Number: 6365153This patent teaches ways of using physical means to stretch out neuronal cells. These neurons can then be inserted into an animal or human with a nervous system injury. This patent is useful for stem cells since the neurons could be generated from progenitors in vitro, then mechanically modified, then placed into the nervous system of the patient.
Inventor: Smith, Douglas H. (Concord/Boothwyn, PA)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Tuesday August 17th, 1999
Porous tissue scaffoldings for the repair or regeneration of tissue
Patent Number: 6365149This patent covers the composition of matter and use of a specialized foam that can be embedded with stem cells and inserted in vivo, or can be inserted in vivo with chemoattractants for stem cells so that the endogenous stem cells repopulate it.
Inventors: Vyakarnam, Murty N. (Edison, NJ); Zimmerman, Mark C. (East Brunswick, NJ); Scopelianos, Angelo George (Whitehouse Station, NJ); Roller, Mark B. (North Brunswick, NJ); Gorky, David V. (Flemington, NJ)
Assignee: Ethicon, Inc. (Somerville, NJ)
Date of First Priority Issue: Wednesday June 30th, 1999
Efficient culture of stem cells for the production of hemoglobin
Patent Number: 6361998This patent teaches how to generate large amounts of erythrocytes by specifically culturing hematopoietic stem cells with cytokines such as IL-3, Stem Cell Factor, and EPO.
Inventors: Bell, David N. (Oakville, CA); Matthews, Kathryn Emma (Toronto, CA); Mueller, Susan G. (Milton, CA)
Assignee: Hemosol Inc. (Mississauga, CA)
Date of First Priority Issue: Friday June 25th, 1999
Genetically modified CD34-negative adherently growing stem cells and their use in gene therapy
Patent Number: 6361997This patent provides stem cells that are mesenchymal-like or lack expression of CD34, for the purpose of transfection with a foreign gene.
Inventor: Huss, Ralf (83666 Waakirchen, DE)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Friday July 24th, 1998
Neuroepithelial stem cells and glial-restricted intermediate precursors
Patent Number: 6361996This patent provides a type of neural stem cell that is capable of differentiating into neural cells and glial cells. Specific properties of the stem cell are covered such as dependence on FGF.
Inventors: Rao, Mahendra S. (Salt Lake City, UT); Mayer-Proschel, Margot (Sandy, UT)
Assignee: University of Utah Research Foundation (Salt Lake City, UT)
Date of First Priority Issue: Wednesday May 7th, 1997
Methods of using multivariant IL-3 hematopoiesis fusion protein
Patent Number: 6361977IL-3 is an important cytokine not only for hematopoietic stem cell proliferation and differentiation, but also for other immune cells and non-hematopoietic stem cells. This patent provides various compositions of matter relating to proteins that stimulate the IL-3 receptor.
Inventors: Bauer, S. Christopher (New Haven, MO); Abrams, Mark Allen (St. Louis, MO); Braford-Goldberg, Sarah Ruth (St. Louis, MO); Caparon, Maire Helena (Chesterfield, MO); Easton, Alan Michael (Maryland Heights, MO); Klein, Barbara Kure (St. Louis, MO); McKearn, J
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Tuesday November 24th, 1992