Patents
Human mesenchymal stem cells
Patent Number: 6387367This patent covers mesenchymal stem cells and provides a specific phenotype for them which includes CD45+, SH2,3,4+, and in some cases CD14+. This patent is important for anyone operating in the area of mesenchymal stem cells since it essentially covers the use of this specific cell population. Patents on cells have been previously upheld by the courts, as was previously illustrated for...
Inventors: Davis-Sproul, Janice M. (Towson, MD); Moorman, Mark Aaron (Baltimore, MD); McNeil, Renee Marie (Baltimore, MD); Simonetti, Jr., Donald William (Forest Hill, MD); Hammill, Lora Catherine (Bel Air, MD); Craig, Stewart (Timonium, MD)
Assignee: Osiris Therapeutics, Inc. (Baltimore, MD)
Date of First Priority Issue: Friday May 29th, 1998
Methods for reducing adverse side effects associated with cellular transplantation
Patent Number: 6387366This patent teaches ways how to overcome some of the negative effects associated with cell therapy in regards to excessive coagulation. It is stated in the specification that in many cases the administration of a cellular therapy results in coagulation of blood due to expression of pro-clotting agents on the surface of the administered blood cells such as tissue factor. The patent teaches ways...
Inventors: Hurwitz, David R. (Boston, MA); Cherington, Van (Harvard, MA); Galanopoulos, Theofanis (Arlington, MA); Levine, Peter H. (Worcester, MA); Greenberger, Joel S. (Sewickley, PA)
Assignee: ALG Company (Marlboro, MA)
Date of First Priority Issue: Thursday December 31st, 1998
Method for transplantation of hemopoietic stem cells
Patent Number: 6383481This patent teaches that intraportal administration of bone marrow subsequent to myeloablation can be used as a therapy for the treatment of autoimmune disease. This approach may be useful since it "reprograms" the immune system, allowing for it to come back into homeostasis. The problem with this is that several severe toxicities are usually associated with transplantation of bone...
Inventors: Ikehara, Susumu (Osaka, JP); Inaba, Muneo (Kyoto, JP); Takeuchi, Kenji (Osaka, JP); Kushida, Taketoshi (Amagasaki, JP)
Assignee: Japan Immunoresearch Laboratories Co., Ltd. (Gunma-Ken, JP)
Date of First Priority Issue: Monday March 30th, 1998
Composition comprising midkine or pleiotrophin protein and method of increasing hematopoietic cells
Patent Number: 6383480This patent covers a cytokine cocktail, that contains midkine, amongst other classical hematopoietic cytokines, useful for the expansion of hematopoietic stem cells. The cocktail may be used for the in vivo treatment of patients that are neutropenic or cytopenic, or may be used for the ex vivo expansion of hematopoietic stem cells.
Inventors: Kikuchi, Makoto (Fukuoka, JP); Ikematsu, Shinya (Kanagawa, JP); Oda, Munehiro (Kanagawa, JP); Sakuma, Sadatoshi (Kanagawa, JP); Muramatsu, Takashi (Aichi, JP)
Assignee: Meiji Milk Products, Co., Ltd. (Tokyo, JP)
Date of First Priority Issue: Wednesday July 10th, 1996
Ligands that modulate differentiation of mesenchymal stem cells
Patent Number: 6379953This patent teaches the use of the molecule ALCAM for induction of mesenchymal cell differentiation. It is also thought in this patent that ALCAM may be useful for the isolation of certain types of mesenchymal stem cells.
Inventors: Bruder, Scott P. (Owings Mills, MD); Jaiswal, Neelam (Ellicott City, MD)
Assignee: Osiris Therapeutics, Inc. (Baltimore, MD)
Date of First Priority Issue: Thursday September 4th, 1997
Biomaterial derived from vertebrate liver tissue
Patent Number: 6379710This patent teaches that one can take an organ from an allogeneic or xenogeneic animal, decellularize the organ, and use the matrix components of the organ as a scaffold to be seeded with stem cells either in vitro or in vivo, and used for the generation of a new organ. In one specific embodiment, livers are generated using this approach.
Inventor: Badylak, Stephen F. (West Lafayette, IN)
Assignee: Purdue Research Foundation (West Lafayette, IN)
Date of First Priority Issue: Tuesday December 10th, 1996
Culture media for neurons, methods for preparing the culture media, and methods for culturing neurons
Patent Number: 6376238This patent provides a culture media for the growth of neuronal stem cells, and neurons themselves. The media is made using standard tissue culture components, with the exception that astroglial cells are used to condition it. The fact that astroglial cells normally produce various compounds that support the nervous system cells is what maybe triggered the inventor to think to condition...
Inventor: Watanabe, Yoshiaki (Akita, JP)
Assignee: Sumitomo Bakelite Co., Ltd. (Tokyo, JP)
Date of First Priority Issue: Tuesday June 27th, 1995
Methods of making conditioned cell culture medium compositions
Patent Number: 6372494This patent teaches how to generate cell conditioned media. The unique part about this patent is that the cells used to condition the media are grown in three dimensional culture.
Inventors: Naughton, Gail K. (La Jolla, CA); Mansbridge, Jonathan N. (La Jolla, CA); Pinney, R. Emmett (Poway, CA) )
Assignee: Advanced Tissue Sciences, Inc. (La Jolla, CA)
Date of First Priority Issue: Friday May 14th, 1999
Serum-derived factor inducing cell differentiation and medical uses thereof
Patent Number: 6372262This patent covers a factor derived from serum by chemical purification techniques that induces stem cell differentiation, and is able to induce differentiation of leukemic cells. Such factors have great possibilities in cancer therapy. Older work by Laurence Burton at the Immune Augmentative Therapy (IAT) clinic actually clinically used such factors with good results in mesothelioma patients...
Inventors: Peled, Tony (Mevaseret, IL); Fibach, Eitan (Mevaseret Zion, IL); Rachmilewitz, Eliezer A. (Jerusalem, IL)
Assignee: Hadasit Medical Research Services & Development Company Ltd. (Jerusalem, IL)
Date of First Priority Issue: Tuesday December 10th, 1996
Method for repopulating human bone marrow comprising culturing CD34+ cells in a serum free medium
Patent Number: 6372210This patent provides tissue culture media and conditions for expansion and growth of hematopoietic cells in vitro. Specifically, this patent is useful for cellular therapy in which the media for growing and maintaining the stem cells has to be chemically defined and effective.
Inventor: Brown, Ronald L. (Derwood, MD)
Assignee: Quality Biological, Inc. (Gaithersburg, MD)
Date of First Priority Issue: Friday October 18th, 1996