Patents
Cell structure media for mammalian cells
Patent Number: 6413772This patent teaches methods of expanding hepatic stem cells, and hepatocytes in culture through a specialized type of serum free media. This media is useful for clinical applications and may be an important part in cellular therapy of hepatic disorders.
Inventor: Block, Geoffrey D. (Pittsburgh, PA)
Assignee: University of Pittsburgh (Pittsburgh, PA)
Date of First Priority Issue: Monday March 18th, 1996
Methods of ex-vivo expansion of hematopoietic cells using interleukin-3 mutant polypeptides with other hematopoietic growth factors
Patent Number: 6413509This patent provides variants of interleukin 3 that are useful for the expansion of stem cells in general, and specifically hematopoietic stem cells. These stem cells may be expanded for a variety of uses including for autologous stem cell transplantation. When methods of inducing hematopoietic stem cell differentiation into other types of tissues are figured out, this patent will be...
Inventors: Bauer, S. Christopher (New Haven, MO); Abrams, Mark Allen (St. Louis, MO); Braford-Goldberg, Sarah Ruth (St. Louis, MO); Caparon, Maire Helena (Chesterfield, MO); Easton, Alan Michael (Maryland Heights, MO); Klein, Barbara Kure (St. Louis, MO); McKearn, J
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Tuesday November 24th, 1992
Method and compositions for isolation and growth of kidney tubule stem cells, in vitro kidney tubulogenesis and ex vivo construction of renal tubules
Patent Number: 6410320This patent covers a type of renal stem cell that is useful for generation of artificial nephrons and eventually artificial kidneys.
Inventor: Humes, H. David (Ann Arbor, MI)
Assignee: The University of Michigan (Ann Arbor, MI
Date of First Priority Issue: Monday March 2nd, 1992
Gene therapy methods using bone marrow-derived cells expressing blood clotting factors
Patent Number: 6410015This patent covers hematopoietic stem cells that are gene transfected with various clotting factors. In some embodiments the stem cells have a preferntially affinity towards injured tissue.
Inventors: Gordon, Erlinda Maria (Glendale, CA); Hall, Frederick L. (Glendale, CA); Anderson, W. French (San Marino, CA)
Assignee: University of Southern California (Los Angeles, CA)
Date of First Priority Issue: Tuesday November 12th, 1996
Methods and articles for regenerating bone or peridontal tissue
Patent Number: 6409764This patent provides methods of using stem cells to generate an artificial bone. Various stem cells are able to be used in the context of this invention, including mesenchymal stem cells. This invention also uses members of the TGF beta family in combination with specialized artificial matrices.
Inventors: White, Charles F. (Camp Verde, AZ); Flynn, Charles (Cottonwood, AZ); Cook, Alonzo D. (Flagstaff, AZ); Hardwick, William R. (Flagstaff, AZ); Wikesjo, Ulf M. E. (Bryn Mawr, PA); Thomson, Robert C. (Flagstaff, AZ)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Thursday December 3rd, 1998
Multipotent neural stem cell cDNA libraries
Patent Number: 6399369This patent provides the genes that are expressed in various neuronal cells and stem cells. These genes are useful for identifying markers of stem cells that can be used for their extraction and isolation. Additionally, knowledge of these genes may enable drug discovery and target identification for ways of expanding and/or differentiating neural stem cells.
Inventors: Weiss, Samuel (Calgary, CA); Reynolds, Brent (Saltspring, CA)
Assignee: Neurospheres Holdings Ltd. (Calgary, CA)
Date of First Priority Issue: Monday July 8th, 1991
Myocardial grafts and cellular compositions useful for same
Patent Number: 6399300This patent teaches ways of purifying out cells expressing myocardial genes from a heterogeneous population of stem cells. Specifically the patent teaches the use of cardiac specific promoters driving expression of markers that can be used to take the cells desired out of a heterogeneous population of cells.
Inventor: Field, Loren J. (Indianapolis, IN)
Assignee: Indiana University Foundation (Bloomington, IN)
Date of First Priority Issue: Tuesday November 16th, 1993
Method and construct for producing graft tissue from an extracellular matrix
Patent Number: 6398819This patent teaches ways of decellularizing tissue, including xenogeneic tissue, so that it may be used as a scaffold to be seeded with human stem cells, and then the stem cells plus tissue scaffold are implanted into the human as an artificial composite tissue.
Inventor: Bell, Eugene (Boston, MA)
Assignee: TEI Biosciences, Inc. (Boston, MA)
Date of First Priority Issue: Friday August 7th, 1992
Genetic engineering of cells to enhance healing and tissue regeneration
Patent Number: 6398816This patent teaches the use of mesenchymal stem cells transfected with "bioactive molecules" (ie cytokines, growth factors, etc), so as to induce repair of bone, cartilage, or connective tissue.
Inventors: Breitbart, Arnold S. (Great Neck, NY); Grande, Daniel A. (Sea Cliff, NY); Mason, James M. (Bethpage, NY)
Assignee: North Shore-Long Island Jewish Research Institute (Manhasset, NY)
Date of First Priority Issue: Thursday September 4th, 1997
Cardiac muscle regeneration using mesenchymal stem cells
Patent Number: 6387369This patent covers the use of mesenchymal stem cells for cardiac repair, specifically after myocardial infarction. Mesenchymal stem cells are currently in clinical trials for this application. In fact the same company to which this patent is assigned to, Osiris Therapeutics, has actually published positive double blind data on patients post infarct treated with allogeneic,
Assignee: Osiris Therapeutics, Inc. (Baltimore, MD)
Date of First Priority Issue: Monday July 14th, 1997