TLRs and Stem Cell Mobilization

Cornell University, New York City, New York -

We have discussed on StemCellPatents.com how various inflammatory stimuli may one the one hand act as stem cell chemo-attractants, and on the other hand may actually cause mobilization of stem cells to leave the bone marrow. For example, injured tissue is associated with platelet activation, causing release of agents such as Friday August 22nd, 2008 @ 19:51:42 EST

Stroke without thrombolytics calls stem cells

Regensburg, Germany -

Bone marrow stem cells are known to possess numerous regenerative properties in humans (clinical trials), including healing of heart attack damaged myocardium, reversing liver failure, and stimulating new blood vessel production in patients with ischemic limbs. Bone marrow...

Monday June 16th, 2008 @ 02:33:35 EST

Notch Ligand Inhibits Angiogenesis

Oxford, UK -

The notch signalling pathway has been widely studied in development and tissue specification. Notch acts as a receptor for various ligands and upon binding translocates into the nucleus to induce expression of various genes. Two ligands of notch, Delta and Serrate have been implicated in the inhibition of stem cell...

Thursday June 12th, 2008 @ 02:43:00 EST

Temporary Hypoxia is Good for Mesenchymal Stem Cells

St Louis, MO -

Mesenchymal stem cells are very exciting since they can be used in an allogeneic manner. While these cells have demonstrated therapeutic effects in liver failure, heart failure, and even diabetes, the main question still remains, how to increase...

Tuesday June 3rd, 2008 @ 10:28:52 EST

Viral Inflammation Mobilizes Stem Cells

Shanghai, China - It is known that various stem cell types, including mesenchymal and hematopoietic have the ability to home to injured tissue. Mechanisms of homing usually are associated with agents such as stromal...

Friday February 29th, 2008 @ 14:55:23 EST

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Acidic mesenchymal stem cells

Los Angeles, CA - Tissue injury is known to cause mobilization of various types of stem cells. For example, after patients have a heart attack, CD34 stem cells, and other types of stem cells are known to mobilize from the bone marrow and enter systemic circulation. Mobilization involves Saturday February 16th, 2008 @ 19:51:40 EST

Cardiac Stem Cell Migration Dependent on p38

Wuhan, China - Many tissues have tissue resident stem cells. Although not in high numbers, these stem cells have nevertheless been demonstrated to play at least some role in regeneration after injury. Stem cells in tissues can be isolated by their side population characteristics, or by their expression of Wednesday December 19th, 2007 @ 11:28:34 EST

Tumors Calling Stem Cells

Galway, Ireland - The possibility of stem cells inducing tumor cell differentiation and thus reducing pathological potential has been speculated by numerous scientists. However, few studies have actually demonstrated that intravenously administered stem cells actually home to the area of tumor localization. Recently it was published (Dwyer et al Monocyte chemotactic protein-1...

Sunday September 9th, 2007 @ 13:50:28 EST

More Seaweed Mobilization

Calgary, Canada - The people behind the company StemTech (multilevel marketing of a product called StemEnhance which supposedly increases circulating stem cells by mobilization) have published a paper describing possible mechanism of action for their stem cell mobilizer (Jensen et al. Mobilization of human CD34CD133 and Tuesday September 4th, 2007 @ 10:12:48 EST

[Watch the Video] The possibility of the immune system doing other things than killing pathogens has been suggested by people like Polly Matzinger for decades. In this paper the authors identified that the C5 component of complement is strictly needed for G-CSF induced mobilization.