Category: Migration (25)
Parathyroid Hormone Mobilizes Stem Cells
Boston, USA - Stem cell mobilizing agents are conventionally used to increase the number of circulating stem cells in peripheral blood so that these stem cells can be harvested and used for transplantation, either in an autologous, or allogeneic manner. Nutritional companies have capitalized on the possibility of mobilizing stem cells by various supplements so as...
Hyaluronic Acid Mediated Mesenchymal Stem Cell Migration
Much is known about CD34+ stem cell migration to areas of hypoxia due to secretion of SDF-1 (CXCL12) by the hypoxia tissue. Migration towards the CXCL12 gradient has been documented in diverse situations ranging from post-myocardial infarction CD34 mobilization to homing of hematopoietic...
Stroke Calls Stem Cells
Nice, France - It is known that after myocardial infarction stem cells exit the bone marrow and enter systemic circulation, possibly as a response to chemoattractants released by injured myocardium. In a recent study (Dunac et al. Neurological and functional recovery in human stroke are associated with peripheral blood CD34+ cell mobilization. J Neurol. 2007...
Stem Cell Cancer Therapy
Bratislava, Slovakia - Various types of stem cells are known to home specifically into neoplastically transformed tissue. In a recent paper (Kucerova et al. Adipose tissue-derived human mesenchymal stem cells mediated prodrug cancer gene therapy. Cancer Res. 2007 Jul 1;67(13):6304-13) this property was leveraged in order to...
Telling Mesenchymal Stem Cells Where to Go
Birmingham, Alabama, USA -
Stem cell migration is an important issue. In situations like bone marrow transplantation for hematpoietic reconstitution, the hematopoietic stem cells are "told" to home to the bone marrow of the recipient by virtue of molecules such as SDF-1 which are... [Watch the Video]
This video reviews data that explains why CXCR4+ stem cells and CXCR4- stem cells home with similar efficiency to the bone marrow. The answer is that the CXCR4 antibody actually blocks signalling, and that CXCR4- cells actually contain intracellular stores of... Beijing, China -
Mesenchymal stem cells are currently being explored by companies such as pluristem for the acceleration of bone marrow hematopoietic stem cell engraftment after transplantation. In a recent study (Shi et al. Regulation of CXCR4 expression in human mesenchymal stem cells by cytokine treatment: role in homing efficiency in
Why Sorted CXCR4+ and CXCR4- Stem Cells Have Similar Engraftment
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Accelerating Mesenchymal Stem Cell Migration
Seaweed mobilization of stem cells
Hobart, Australia - Stem cell mobilization from the bone marrow is clinically performed by administration of cytokines such as G-CSF in order to collect peripheral blood stem cells, primarily for the purposes of bone marrow transplant. Other newer uses include the mobilization of stem cells in order to accelerate healing of cardiac infarcts, as well as induction of angiogenesis by...
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Calling All Stem Cells !!!
Minneapolis, Minnesota - It is known that subsequent to cardiac infarction, various cytokines are produced by the injured myocardium that mobilize endogenous stem cells from the bone marrow into systemic circulation, and specifically "calling" them to home to the ischemic tissue. Unfortunately, this process occurs only to a small extent and full repair of the myocardium after injury...
Endotoxin decreases circulating EPC
Vienna, Austria - Circulating endothelial progenitor cell levels have been reported to increase with exercise, smoking cessation, as well as taking statin drugs...amongst other things. In a recent paper it was demonstrated that endotoxin induces a temporary (24 hr) decrease in the number of circulating endothelial progenitors (Mayr et al. Effects of low dose endotoxemia on endothelial...