Class: Use (276)
Stem cells and their use in transplantation
Patent Number: 7,537,756The problem with islet transplantation is that one needs 2-3 pancreatic donors per recipient, and even this high number of islets still end up eventually being rejected/nonfunctional. Additionally the recipient needs to be on immune suppression. These drawbacks are not only because of allogeneic issues, but also due to poor vascularization once the islets are injected via the...
Method of transplanting in a mammal and treating diabetes mellitus by administering a pseudo-islet like aggregate differentiated from a nestin-positive pancreatic stem cell
Patent Number: 6866843This patent teaches extraction of pancreatic stem cells based on expression of nestin...expansion of the cells into islet-like cells...and transplantation of the cells for treatment of diabetes. The problem is how much expansion can one achieve? Since there is a SEVERE shortage of donor pancreas'. The other problem, of course, is the need for immune...
NK-2 homeobox transcription factor
Patent Number: 7,183,397The NK-2 homeobox transcription factor family are responsible for tissue specification and are found in a variety of stem cells. The ability to modulate such transcription factors has numerous applications in the area of stem cells since such modulation could be used to guide differentiation into specific tissues. The current patent claims the composition of matter for one such family...
Use of treosulfan for patient conditioning before bone marrow or blood stem cell transplantation
Patent Number: 7,199,162During bone marrow or peripheral blood stem cell transplant, it is typical to perform preconditioning of the recipient. This is done in order to wipe out host derived hematopoiesis, and to "make room" for the donor stem cells. Additionally, in conditions of hematological neoplasia, recipient conditioning is performed with the idea of eradicating cancer cells. Numerous protocols and...
Production of a biological factor and creation of an immunologically privileged environment using genetically altered Sertoli cells
Patent Number: 7,399,751This is a patent with priority in 1999 describing the use of genetically modified Sertoli cells for immune protection of implanted cells AND the use of the Sertoli cells themselves as the vector...genetic engineer with any gene is covered.
This patent is part of the Canadian company Sernova's (CDNX:SVA.V) potent intellectual property...
Method of preparing suppressor T cells with allogeneic mesenchymal stem cells
Patent Number: 6281012This patent covers the use of mesenchymal stem cells to generate T suppressor cells in general. Specifically it mentions that CD8 positive T cells can be turned into suppressor cells by contact with mesenchymal stem cells. Usually, T suppressor cells are called T regulatory cells and this refers to CD4+ CD25Inventors: McIntosh, Kevin (Ellicott City, MD); Klyushnenkova, Elena (Baltimore, MD)
In vivo assay and molecular markers for testing the phenotypic stability of cell populations and selected cell populations for autologous transplantation
Patent Number: 7,479,367Autologous stem cell transplantation has given positive results in cardiac, hepatic, and various ischemic conditions.
The current patent addresses the use of autologous chondrocyte populations for treatment of various cartilage disorders. Cartilage destruction is often seen in...
Method for in vivo ex vivo and in vitro repair and regeneration of cartilage and collagen and bone remodeling
Patent Number: 6528052This patent discloses frequencies and methods of culturing stem cells in order to generate a source of bioartificial cartilage.
Adipose tissue-derived adult stem or stromal cells for the repair of articular cartilage fractures and uses thereof
Patent Number: 7078232Repair of articular cartilage is a substantial problem. The patent is useful for entities interested in providing a solution to this problem through the administration of cellular therapy containing adipose-derived stem cells in a biocompatible matrix or delivery system. The patent specifically has 4 independent claims. The first claim covers a composition of matter that is useful for...
Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair
Patent Number: 7033587This patent teaches ways to make artificial cartilage patches using adipose stem cells as starting material. These patches may be useful for people having injuries in which cartilage is damaged. The patent has 1 independent claim which essentially covers producing such an artifical patch through taking out adipose stem cells, culturing the cells to become chondrocytes, allowing the...