Class: Use (276)
Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair
Patent Number: 6841150This appears to be a very important patent in that it teaches the use of adipose stem cells for generating chondrocytes and using the chondrocytes to heal cartilage. This patent should be compared to ones by Osiris that use adipose derived mesenchymal stem cells for cartilage repair, as well as by Cytori which uses adipose derived stem cells for a variety of indications.
Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair
Patent Number: 6429013This patent teaches how to generate cartilage and chondrocytes from stromal cells that are derived from adipose tissues. Another company working heavily in this area is Cytori, formerly called Macropore.
Treatment of liver disease and injury with CXC chemokines
Patent Number: 6719969This patent teaches that CXC chemokines are potent stimulators of hepatic stem cells and hepatic regeneration. Chemokines covered include MIP-2, ENA-78 and IL-8.
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Muscle cells and their use in cardiac repair
Patent Number: 6673604This is a composition patent covering myocardial and fibroblast cell preparations that are useful for administration in the post-infarct myocardium. This approach is interesting and a similar approach seems to have been used clinically by the company Bioheart.
Ischemia detection system
Patent Number: 6277082This patent provides a medical device that detects ischemia based on electrical conductivity and other parameters. This invention is useful in combination with stem cell therapy so as to enable the administrator of stem cell angiogenic therapy to decide when and where therapy is needed.
Hematopoietic cell composition for use in transplantation
Patent Number: 7101708This patent is useful for parties looking to increase bone marrow stem cell homing to areas of need. In normal bone marrow transplants, stem cells from the donor are introduced intravenously and find their way to the bone marrow by virtue of bone marrow-secreted stromal derived factor-1 (SDF-1). It was more recently discovered that following tissue injury (for example stroke and myocardial...
Devices and methods for treating tissue
Patent Number: 6719805This patent seems to cover the use of angiogenic stimuli, together with stem cells for treatment of muscle disorders including disorders associated with the myocardium. This patent may influence the current trials ongoing for treatment of myocardial dysfunction with stem cells and angiogenic stimuli.
Methods of inducing nervous tissue regeneration
Patent Number: 6569423This patent teaches how to induce neuronal stimulation and production of new neurons through administration of Schwann cells that express the protein DELTA.SCIP.
Production of pancreatic islet cells and delivery of insulin
Patent Number: 7,323,165Numerous approaches have been patented on the treatment of diabetes through regeneration. These range from bone marrow stem cell modification and administration, to generation of islets from embryonic stem cells, to creation of differentiated proliferating
Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyaluronans
Patent Number: 6911429Tissue injury is associated with increased concentrations of hyaluronan (hyaluronic acid, HA). HA modifies cell behavior, including causing fibrosis and inflammation through interaction with cell-associated receptors such as receptor for HA-mediated motility (RHAMM, CD168).
The present invention provides compounds that bind to HA and thereby inhibit the...