Class: Expansion (424)
Loop peptide and TGF.alpha. for stimulating stem cell proliferation and migration
Patent Number: 7,365,172Stem cells need to be maintained in a quiescent state when they are not needed to make new cells. This is because if stem cells were consistently proliferating then there would be a high propability of mutations, thus leading to cancer. One of the methods that stem cells maintain themselves in a non-proliferating state is through autocrine secretion of inhibitory factors. ...
Loop peptide and TGF.alpha. for stimulating stem cell proliferation and migration
Patent Number: 6764683Mucositis is a big problem in cancer patients taking chemotherapy and radiation therapy, in part due to the effect of these therapies on the epithelial stem cell pool. This patent teaches the usefulness of transforming growth factor alpha on preventing this condition by its ability to protect the stem cell compartment and to enhance their expansion.
Method for ex-vivo expansion of hematopoietic cells
Patent Number: 6251383This patent covers the use of an extract of the plant called Tinospora cordifolia for stimulation of hematopoietic stem cells.
G-CSF mimetics
Patent Number: 6346531This patent provides compositions of matter that are useful for stimulating the receptor for granulocyte colony stimulating factor. The fact that G-CSF was the first drug introduced that acted on the level of stem cells suggests that this is an important area for drug development. This patent may be useful not only for stimulation of neutrophil function, but also for increasing stem...
Combinations and methods for promoting in vivo liver cell proliferation and enhancing in vivo liver-directed gene transduction
Patent Number: 6790838This patent teaches ways of improving the transfection of liver cells with genes in vivo. Transfection of liver cells is performed through the administration of the thyroid hormone T3, as well as keratinocyte growth factor. The transfection of liver cells may be performed not only for treatment of genetic disorders, but also for induction of islet...
Combinations and methods for promoting in vivo liver cell proliferation and enhancing in vivo liver-directed gene transduction
Patent Number: 6248725This is an interesting patent that teaches the concurrent administration of the thyroid hormone T3, together with keratinocyte growth factor (KGF) can stimulate proliferation of endogenous hepatic stem cells.
Proteins related to neuronal regeneration and uses thereof
Patent Number: 6783982This patent teaches that neural stem cells can be expanded through the use of a novel protein called Neural Plakophilin Related Armadillo Protein (hNPRAP). Additionally the patent claims the induction of cellular extensions ushing hNPRAP.
Propagation of human hepatocytes in non-human animals
Patent Number: 6995299This patent teaches ways of growing human hepatocytes in xenogenic hosts. This patent would be useful for using animals as "bioincubators" in order to grow organs or cells for human use. Specifically the patent has two independent claims. The first covers a model of hepatitis C in which a mammal is injected with human hepatocytes when it is in the fetal stage, thus becoming...
Use of vascular endothelial growth factor to treat photoreceptor cells
Patent Number: 7,223,724Macular degeneration and various other types of ocular pathology are usually associated with uncontrolled proliferation of blood vessels near the retina. The covering of nerves by new blood vessels usually causes dysfunction of the nerves and in some cases blindness. It is known that the compound VEGF is associated with pathological angiogenesis, and accordingly, the...
Method of expanding undifferentiated hemopoietic stem cells
Patent Number: 7,534,609Expansion of hematopoietic stem cells would, at face value, allow the possibility of curing many hematological diseases by the process of selecting non-leukemic stem cells, ex vivo expanding them, and providing them back to the patient after myeloablation has destroyed the resident malignant cells.
Pluristem (Nasdaq:PSTI) is...