Class: Expansion (424)

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Electrical field therapy with reduced histopathological change in muscle

Patent Number: 6678556

This patent covers ways of in vivo transfecting cells by means of electroporation without inducing inflammatory or tissue damaging changes. I have included this in the "expansion" section of the StemCellPatents.Com database since electroporation can be used for cytoplasmic transfect of cytoplasm from embryonic stem cells into various tissues, so as to endow the tissues with stem cell like...

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Inhibitors of proteasomal activity for stimulating hair growth

Patent Number: 7,223,554

This patent covers the composition of matter for several inhibitors of proteasomal activity including inhibitors of the chymotrypsin-like activity, and NF-KB inhibitors that stimulate hair growth. The invention has demonstrated efficacy in several animal models and is currently being developed by the San Francisco company Neosil. One wonders whether inhibition of inflammation-associated...

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Inhibitors of proteasomal activity for stimulating hair growth

Patent Number: 7,175,994

Stimulation of dermal papillary cells for hair regrowth is an area of intense scientific interest. In the current patent, the use of proteosomal inhibition in general is claimed, along with several growth factors for stimulation of hair growth. Specifically covered growth factors are EGF, FGF, PDGF, TGF, IGF, LIF, and parathyroid hormone. This patent also covers the...

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Inhibitors of proteasomal activity for stimulating bone growth

Patent Number: 6902721

This patent teaches that proteosome inhibitors stimulate the growth of bone, in part through inhibition of the inflammatory-associated transcription factor NF-kB. It is unclear if the stimulation of bone growth works via activation of stem cells, or other mechanisms. The patent also discloses use for stimulation of hair growth, but that is not in the claims. The one independent claim...

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Inhibitors of proteasomal activity for stimulating hair growth

Patent Number: 6884769

Proteosomes are becoming important biological targets in drug discovery. For example pathways associated with numerous diseases, such as NF-kB are dependent on proteosomal activation. In the case of NF-kB the proteosomal degradation of phosphorylated IKB is what allows translocation of NF-kB into the nucleus. In this patent inhibition of the chymotrypsin-like...

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Methuselah gene, compositions and methods of use

Patent Number: 6906181

The Methuselah gene mutation is associated with enhanced longevity. Specifically, flies with methuselah (mth) have approximately a 35 percent increase in average life-span and enhanced resistance to various forms of stress, including starvation, high temperature, and dietary paraquat, a free-radical generator (Lin YJ, et al. Extended life-span and stress...

Assignee: California Institute of Technology (Pasadena, CA)

Date of First Priority Issue: Tuesday July 7th, 1998

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Vitro maintenance of hematopoietic stem cells

Patent Number: 6030836

This patent covers expansion of hematopoietic stem cells by culturing with allogeneic or autologous mesenchymal stem cells.

Inventors: Thiede, Mark A. (Forest Hill, MD); Pittenger, Mark F. (Severna Park, MD); Mbalaviele, Gabriel (Columbia, MD)

Assignee: Osiris Therapeutics, Inc. (Baltimore, MD)

Date of First Priority Issue: Monday June 8th, 1998

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Biomaterials containing hyaluronic acid derivatives in the form of three-dimensional structures free from cellular components or products thereof for the in vivo regeneration of tissue cells

Patent Number: 6872819

This patent describes biomaterials that can be administered in an area of tissue injury to allow for stem cells to expand locally and produce new functional tissue. The biomaterials covered appear to be hyaluronic acid based.

Inventors: Pavesio, Alessandra (Padua, IT); Dona' , Massimo (Due Carrare, IT); Callegaro, Lanfranco (Thiene, IT)

Assignee: Fidia Advanced Biopolymers S.r.l. (Brindisi, IT)

Date of First Priority Issue: Wednesday May 27th, 1998

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G-CSF mimetics

Patent Number: 6630470

G-CSF has many properties associated with stimulation of stem cells. In this patent compositions of matter for mimetics of G-CSF are provided. This patent can be used for treatment of neutropenia and other conditions that G-CSF is currently used for.

Inventors: Luengo, Juan I (Audubon, PA); Duffy, Kevin J (Norristown, PA)

Assignee: SmithKline Beecham Corporation (Philadelphia, PA)

Date of First Priority Issue: Friday May 22nd, 1998

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Hematopoietic stimulation

Patent Number: 7067489

The invention is useful for stimulating hematopoiesis, preventing low levels of hematopoietic cells and producing increased numbers of hematopoietic and mature blood cells which can be used both in vivo and in vitro. It appears that CD26 is a peptidase that cleaves certain proteins, including hematopoietic growth factors. Additionally, CD26...

Inventors: Wallner, Barbara P. (Cohasset, MA); Jones, Barry (Cambridge, MA); Miller, Glenn T. (Merrimac, MA); Adams, Sharlene (Waltham, MA)

Assignee: Point Therapeutics, Inc. (Boston, MA)

Date of First Priority Issue: Monday May 4th, 1998

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