Class: Expansion (424)
Low oxygen culturing of central nervous system progenitor cells
Patent Number: 6610540This patent teaches that low oxygen conditions may be used in the expansion and differentiation of undifferentiated mesencephalic stem cells. This is interesting since in the hematopoietic system the early stem cells also prefer growth in the relatively hypoxic niches of the marrow.
Methods for isolation and activation of, and control of differentiation from, skeletal muscle stem or progenitor cells
Patent Number: 6184035This patent teaches ways of growing muscle stem cells through exposure to low oxygen tension and other tissue culture media.
Uses of recombinant colony stimulating factor-1
Patent Number: 5837229Covered in this patent is the use of the cytokine currently named M-CSF, for the expansion of hematopoietic stem cells and their differentiation along the myeloid lineage. Mice that are knocked out for M-CSF do not have functional macrophages, but also do not have tumor associated angiogenesis.
Serum-free medium for mesenchymal stem cells
Patent Number: 7,109,032This patent covers a tissue culture media composition that dose not require the addition of exogenous sera. The tissue culture composition is suitable for expanding mesenchymal stem cells and alleviates the need for serum through addition of the following proteins which are known to stimulate various types of stem cells: basic fibroblast growth factor, leukemia inhibitory factor, and stem cell...
Thrombopoietic compounds
Patent Number: 6835809This patent covers a peptide that stimulates stem cells to differentiate into the megakaryocytic lineage. This patent is useful for acceleration of platelet recovery after chemotherapy, radiation therapy, or bone marrow transplant. Since thrombopoietin stimulates early stem cells to self-renew, it may be interesting to see if this peptide also has similar activities.
Pharmaceutical composition of BUF-5 for treating anemia
Patent Number: 5200395This patent covers the use of a peptide called BUF-5 for the treatment of anemia. Based on the literature we could not find what exactly BUF-5 is. This could be a very interesting patent for treatment not only of various forms of anemia, but also other hematological diseases in which stimulation of the erythrocyte progenitor is...
Method of stimulating growth of melanocyte cells by administering stem cell factor
Patent Number: 6852313Melanocyte proliferation may be desired in a variety of pathological conditions. Melanocytes are important, for example in burn patients where it is desireble to obtain a sufficient layer of skin so as to avoid scepticemia. Melanocytic proliferation is demonstrated in this patent by treatment with stem cell factor (kit-ligand), as well as combinations of stem cell factor with other cytokines...
Angiogenically effective unit dose of FGF-2 and method of use
Patent Number: 7,541,333Stimulation of therapeutic angiogenesis offers great potential, not only for the obvious conditions such as critical limb ischemia and angina, but also for other indications post-stroke recovery and liver failure. Methods of stimulating angiogenesis range from administration of
Angiogenically effective unit dose of FGF-2 and method of use
Patent Number: 6440934This patent covers specific doses of FGF-2 that may be used for the stimulation of angiogenesis. Angiogenesis stimulation should not be thought of as important only for disease such as angina, but for other disease associated with ischemia such as cerebral palsy, and peripheral vascular disease.
Vasostatin as marrow protectant
Patent Number: 7,432,236Destruction of the bone marrow by chemotherapy or radiotherapy causes significant morbidity and mortality. In fact, hematopoietic toxicity is the main limiting factor of many types of chemotherapeutic agents. Accordingly, it would be interesting if one were to develop an agent or therapeutic approach that could protect the bone marrow, or alternatively, allow bone marrow cells to...