Class: Expansion (424)
Method of producing undifferentiated hemopoietic stem cells using a stationary phase plug-flow bioreactor
Patent Number: 6911201One of the limiting factors to clinical use of autologous hematopoietic stem cells, as well as cord blood cells, is the limited ways of expanding them. This patent addresses this issue by providing a novel system for such expansion that appears to be more "in vivo-like". Essentially, the patent has 2 independent claims covering:
A method of expanding undifferentiated... This patent teaches the novel use of melanoma inhibitory factor to induce stem cell differentiation into bone and cartilage. It may be used for in vitro generation of stem cells or for acceleration of in vivo healing. The independent claims of the patent are:
A method for inducing chondro-/ostrogenic lineage and promoting of cartilage or bone formation in a person... This patent teaches the use of antibodies to TGF beta in order to stimulate hematopoietic stem cell renewal. Hematopoietic stem cells generation secrete autocrine TGF beta which inhibits their proliferation. This patent inhibits the inhibitor thus attaining stem cell expansion. Like many biological pathways activated in stem cells, the pathways associated with hedgehog signalling are also associated with cancer. In this invention methods of modulating the hedgehog signalling pathway are provided that can be useful for controlling normal stem cells, as well as cancer cells. This patent covers a strange modified G-CSF protein that is not G-CSF but possesses properties of G-CSF. It seems really interesting for easy commercialization...especially for "biogeneric" G-CSF. This patent teaches the use of growth hormone to stimulate hematopoiesis. The fact that various hormones have hematopoietic activity suggests that it may be worthwhile to assess their activity on the growth of neural stem cells both in vitro, but also in vivo.
I believe that there is evidence of hormones like testosterone increasing mental acuity in elderly patients...could this have... This patent covers culture techniques and cells that are useful for the growth and expansion of primitive hematopoietic stem cells. One of the interesting aspects of this patent is that it uses human endothelial cells that are derived from the brain as feeder cells. Given all of the interesting correlations between brain cells and bone marrow hematopoietic stem cells, this patent is... This patent teaches how to generate a vascularized tissue in vitro for subsequent implantation in vivo. This patent covers the use of neural stem cells together with a growth hormone for treatment of neurological conditions. This covers various hormones including growth hormone itself, as well as fibroblast growth factor. This patent teaches that neural stem cells, specifically neural crest stem cells, can be expanded preferentially by growing in low oxygen conditions.
Use of a melanoma inhibiting activity factor (MIA) for cartilage and bone repair
Patent Number: 6890897
Anti-transforming growth factor Beta (TGF-.beta.) treated stem cell composition and method
Patent Number: 6627191
Regulators of the hedgehog pathway, compositions and uses related thereto
Patent Number: 6686388
Nucleic acids and protein variants of hG-CSF with granulopoietic activity
Patent Number: 7,208,473
Human growth hormone to stimulate hematopoiesis and immune reconstitution after hematopoietic stem cell transplantation in humans
Patent Number: 6348444
Human brain endothelial cells and growth medium and method for expansion of primitive CD34+CD38-bone marrow stem cells
Patent Number: 6642049
Methods and articles for regenerating living tissue
Patent Number: 6328765
Medicinal product and method for treatment of conditions affecting neural stem cells or progenitor cells
Patent Number: 6797264
Low oxygen culturing of neural crest stem cells and methods of use
Patent Number: 6759242