Class: Expansion (424)
Vasostatin as marrow protectant
Patent Number: 6596690This patent covers the new use of vasostatin in inhibiting the killing of stem cells from agents that are cytotoxic the mitotic cells such as radiation and chemotherapy.
Methods and devices for the long-term culture of hematopoietic progenitor cells
Patent Number: 6440734This patent discloses various three dimensional biomaterials that resemble the actual bone marrow microenvironment and are useful for stimulating expansion of hematopoietic stem cells. This patent may be used for expanding autologous stem cells for patients that lack a suitable bone marrow or stem cell donor. Additionally, the ability to expand and grow hematopoietic stem cells can...
Electroactive materials for stimulation of biological activity of bone marrow stromal cells
Patent Number: 6,190,893This patent is useful for parties interested in altering the biological activity of stromal cells of the bone marrow, particularly in the area of bioengineering. The invention has 5 independent claims. The first covers a method for stimulating biological activities (gene expression, growth, differentiation, transduction, and combo) in bone marrow stromal cells by contacting with an...
Use of fibroblast growth factor 2 for expansion of chondrocytes and tissue engineering
Patent Number: 6582960This patent teaches that FGF-2 can actually de-differentiate certain cells, and be used for the formation of chondrocytes. This would be useful for cartilage repair, as well as for various tissue regenerative purposes.
Electroactive materials for stimulation of biological activity of stem cells
Patent Number: 6569654This patent teaches ways of stimulating virtually all possible biological activities from mesenchymal stem cells through the contact with electroactive materials.
Serum-free medium for mesenchymal stem cells
Patent Number: 7109032This patent is useful for parties seeking to expand mesenchymal stem cells, particularly for clinical applications. The invention generally teaches tissue culture media and techniques that alleviate the need for using serum. Since serum is usually from animal origin (fetal calf serum) or in some cases of human origin, there exists possibilities of contaminating cellular sources. The...
Genes in the control of hematopoiesis
Patent Number: 6451558This patent covers some genes whose function is not really described in the application. In order to understant the relevance of this patent, one should take the sequence and blast it in genbank to see what the real name of this gene is.
Targeting pharmaceutical agents to injured tissues
Patent Number: 6955898This patent teaches was of targeting damaged tissue with genes that stimulate angiogenesis. Conceptually the technology could be modified to introduce agents which actually stimulate stem cell proliferation at the site of injury. The patent has one issued claim that covers a fusion polypeptide, with one end having a collagen binding domain which binds exposed vascular collagen (ie during...
Method for maintenance and propagation of germline stem cells using members of the TFG-.beta. family of growth factors
Patent Number: 6800790This patent teaches how to increase the number of germline stem cells in a fruitfly through overexpression of Dpp locally using certain promoters that are specific to germline stem cells. Since the patent is only covering the fruitfly species, clinical applications seem to be limited.
Cell expansion system for use in neural transplantation
Patent Number: 6787356This patent teaches methods of generating and expanding dopaminergic neurons that can be used for treatment of a variety of neurological conditions. The system uses, amongst other things, fibroblast growth factor for expansion.