Class: Expansion (424)
Hematopoietic stimulation
Patent Number: 6770628This patent takes a new twist on stimulation of hematopoietic stem cells. It uses inhibitors of Dipeptidyl Peptidase IV, an enzyme that destroys hematopoietic growth factors, in order to "suppress the suppressor".
Hematopoietic stimulation
Patent Number: 6300314CD26 is an ectoenzyme that is found on numerous cells including stem cells. The enzyme performs numerous functions that inhibit stem cell proliferation. This patent provides a composition of matter that potently inhibits the CD26 ectoenzyme activity and thereby stimulates proliferation of hematopoietic stem cells. This patent would be...
Human desert hedgehog protein
Patent Number: 7098026This is a composition of matter patent covering the human desert hedgehog protein which is critically involved in various stages of development. The hedgehog proteins have applications in stem cell proliferation and differentiation. This patent is critical for anyone looking to use the desert hedgehog protein as a therapeutic. Potential areas of therapeutics include regeneration of...
Cytokine-like proteins that promote cell proliferation
Patent Number: 6610285This patent covers a composition of matter that is a little similar to G-CSF in structure. The composition is useful for expansion of hematopoietic stem cells and several other types of cells.
Human growth-associated methyltransferases
Patent Number: 6132714This patent covers the composition of matter for several methyltransferases that are associated with stem cell renewal. These methyltransferases may be associated with activity of numerous cell types in addition to hair follicle stem cells.
Methods for treating a patient undergoing chemotherapy
Patent Number: 6762167This patent teaches that angiotensin I and/or angiotensin II can be used for stimulation of hematopoiesis.
Methods for introducing heterologous cells into fish to determine if the heterologous cells contain cancer cells or a pathogen
Patent Number: 7,408,095In general it is quickly forgotten that the biggest contribution of embryonic stem cell technology to medicine has not been in the area of actually generating therapeutics, but in development of model systems for studying diseases. It was only through the generation of knockout and transgenic animals that we as biologists were able to start deciphering the in vivo relevance of the...
Methods of controlling proliferation and differentiation of stem and progenitor cells
Patent Number: 7,169,605Ex vivo expansion of stem cells offers the possibility of using autologous cells for the treatment of diseases ranging from hematopoietic disorders to post myocardial infarction cardiac regeneration. Stem cell therapy with adult cells is often limited by the fact that it is difficult to obtain high enough numbers of cells for performing repeated administration. Additionally, stem cells from...
Methods of controlling proliferation and differentiation of stem and progenitor cells
Patent Number: 7,429,489In addition to their usefulness for making new blood cells, hematopoietic stem cells have been demonstrated to induce regeneration of injured liver in cirrhosis patients, possess therapeutic effects in heart failure, and possible are associated with recovery of patients after
Methods of controlling proliferation and differentiation of stem and progenitor cells
Patent Number: 6887704This patent teaches the ex vivo expansion of stem cells of the hematopoietic lineage through culture in conditions having reduced copper content. The patent is useful for expanding CD34 stem cells for treatment of a variety of diseases and conditions in which CD34 numbers and/or activity may be beneficial. The fact that copper chelation is...