Class: Expansion (424)
Methods of using mutant flt3-ligand polypeptides to induce cellular expansion
Patent Number: 7067118This invention teaches ways of generating active portions of the stem cell expanding protein flt-3L and using these active portions. The assignee is the same company, (Immunex) that developed the original flt-3L. The patent has 4 independent claims. The first covers expanding stem cells, the second covers in vivo expansion, the third covers transplanting cells and expanding them in vivo, the...
Methods for treating a patient undergoing chemotherapy
Patent Number: 7,338,938The current patent covers the use of a peptide derived from angiotensin I for stimulation of hematopoiesis after insult to the blood making system of a host. Specifically, the patent addresses the hematopoietic insult of chemotherapy. Since many types of chemotherapeutic agents kill proliferating cells, the hematopoietic system is often injured as a consequence of administration of these...
Method for promoting mesenchymal stem and lineage-specific cell proliferation
Patent Number: 6248587This patent provides the use of angiotensinogen I, II, and various analogues thereof in order to accelerate proliferation and differentiation of mesenchymal stem cells that are in contact with various types of other cells.
Hematopoietic stem cell proliferating agents
Patent Number: 7037892Stimulation of hematopoiesis in patients who are neutropenic after chemo, or radiation is a major goal of medicine. This is particularly important due to infectious disease complications that arise in patients that have been myeloablated. This patent teaches the use of insulin like growth factor as an adjuvant to several of the major stimulators of hematopoiesis that are already in the...
Identification of a G protein-coupled receptor transcriptionally regulated by protein tyrosine kinase signaling in hematopoietic cells
Patent Number: 6569995This patent covers an antibody that binds to GPCR involved in stem cell expansion and differentiation.
Thymosin .alpha.1 promotes tissue repair, angiogenesis and cell migration
Patent Number: 6197751Thymosin is expressed by the thymus and is associated with immune stimulation. In this patent the ability of thymosin to augment regeneration of tissue, as well as stimulate stem cells is patented. It is interesting that the production of thymosin actually decreases, as well as general thymic function with age. This patent may be a way to induce longevity by administration of...
Hypoxia mediated neurogenesis
Patent Number: 6368854Bone marrow stem cells and other types of stem cells prefer to reside in conditions of hypoxia. In this patent, the use of hypoxia for inducing differentiation of neural stem cells into neurons is disclosed.
Feeder-free culture method for embryonic stem cells or primate primordial stem cells
Patent Number: 7,413,902This patent covers the expansion of embryonic stem cells (referred to in the patent as primate primordial stem cells) by growing them in a media that lacks feeder cells but has the extracellular matrix of lysed fibroblast cells. It also covers growth of embryonic stem cells in extracellular matrix combined with agents such as FGF, forskolin, and various nutrients. The point of the...
Methods and materials for the growth of primate-derived primordial stem cells in feeder-free culture
Patent Number: 6800480This patent teaches how to grow embryonic stem cells in absence of feeder cells. This is a useful "base patent" that is essential to generation of therapeutics from embryonic stem cells, since it is usually not desired to use feeder cell layers in culture of embryonic stem cells for clinical use.
Compounds and methods for inhibiting the interaction between .alpha.-catenin and .beta.-catenin
Patent Number: 7063842The catenins are involved in numerous cell to cell interactions. This patent covers ways of inhibiting alpha and beta catenin interactions using a chemical composition. Specifically, the patent has 3 independent claims. The first is for modulating the interaction between alpha and beta catenin with specific peptides and antibodies. The second is for a pharmaceutical composition. The...