Class: Expansion (424)
Stimulation of hematopoietic cells in vitro
Patent Number: 7,276,371Ex vivo expansion of CD34 hematopoietic stem cells is a highly desired goal. If it was possible to effectively expand these cells, then not only would autologous hematopoietic stem cell transplants be more clinically successful, but also numerous ex vivo cellular therapies would be possible. Unfortunately, many companies have developed numerous ex vivo cell expansion...
Stimulation of hematopoietic cells in vitro
Patent Number: 6258597The enzyme dipeptidyl peptidase is expressed on a variety of cells including stem cells. This enyzme inhibits the ability of stem cells to proliferate. This patent provides an "inhibitor of inhibitor" so as to stimulate stem cell proliferation.
Methods and devices for the long-term culture of hematopoietic progenitor cells
Patent Number: 7067316This patent is useful for the long term, in vitroculture of hematopoietic progenitor cells in the absence of exogenously added hematopoietic growth factors. It appears that the inventors developed a system that replicates the bone marrow structure but does not require addition of cytokines or other growth factors, or serum. The invention has 2 independent claims. The first covers a porous...
Methods and devices for the long-term culture of hematopoietic progenitor cells
Patent Number: 6645489This patent covers ways for the in vivo culture and expansion of hematopoietic stem cells. The advantage of expanding such hematopoietic stem cells in vivo is that they are subjected to more "biological" conditions and at least theoretically should work better than other in vitro systems.
Synergistic composition and methods for treating neoplastic or cancerous growths and for restoring or boosting hematopoiesis
Patent Number: 6998125Despite its title, the patent doesn't really deal with stimulation of hematopoiesis. It covers a method of immunizing a cancer pateint with tumor antigens and concurrenly inhibiting TGF-beta. It is known that TGF-beta is an immunosuppressive agent released by cancer cells. It may be that since TGF-b inhibits...
Cultures of human CNS Neural stem cells
Patent Number: 6777233This patent provides a tissue culture media and systems that can be used to expand nestin positive neural stem cells. The neural stem cells that are expanded in this patent have more potency and appear to be more undifferentiated than neural stem cells that are covered in the prior art.
Cultures of human CNS neural stem cells
Patent Number: 6498018This patent appears to cover a method of screening for compounds that have ability to induce expension of neuronal stem cells. In one of the dependent claims the patent covers forebrain derived neural stem cells in the culture for screening.
Cultures of human CNS neural stem cells
Patent Number: 6103530This patent provides a tissue culture media that is useful for the growth and expansion of neural stem cells.
Hematopoietic stem cell proliferating agents
Patent Number: 6495365This patent covers the use of IGF-1 (a protein that is already in the clinic) in combination with a protein selected from the group comprising of: G-CSF, M-CSF, or stem cell factor, for the stimulation of hematopoiesis. This patent should be examined for the possibility of extending this technology to the area of other uses of hematopoietic stem cells. For example...
Cysteine variants of granulocyte-macrophage colony-stimulating factor
Patent Number: 7,148,333G-CSF is a potent hematopoietic stem cell growth factor used clinically under the name Neupogen, made by Amgen, for accelerating granulopoiesis. One of the disadvantages of protein therapeutics in general is poor bioavailability and short half life. The current patent discloses methods of modifying G-CSF so as to allow for site-specific conjugation with polyethylene glycol which is...