Class: Expansion (424)
Method of treating leukopenia with adenosine
Patent Number: 6911435Lack of leukocyte production, leukopenia, is a major morbidity and mortality factor in patients recieving high dose chemotherapy, as well as after bone marrow transplant. This patent is very useful since it teaches how to expand hematopoietic stem cell production of leukocytes through administration of adenosine, a compound that is already clinically used. The patent has two independent...
Human jagged polypeptide, encoding nucleic acids and methods of use
Patent Number: 6136952This patent covers the composition of matter of JAGGED and various peptide derivatives. JAGGED is important embryonically for development, as well it has stimulatory activity on a wide variety of stem cells.
Method for promoting hematopoietic and mesenchymal cell proliferation and differentiation
Patent Number: 7,118,748This patent covers the use of angiogensinogen I, II and specific derivatives for stimulation of hematopoietic and stem cell proliferation.
Method and article to induce hematopoietic expansion
Patent Number: 5948426This patent covers a matrix derived from bone that is able to induce the proliferation and expansion of hematopoietic stem cells in vitro.
Cationic lipid compositions targeting angiogenic endothelial cells
Patent Number: 7094424This patent teaches ways of selectively targeting a compound to endothelial cells. This could be used to administer stem cell stimulators in order to increase angiogenesis. The patent has one independent claim,that is "A method for selectively labeling angiogenic endothelial cells in vivo, the method comprising administering to a mammal a liposomal complex comprising cationic lipids and a...
Methods of using hedgehog proteins to modulate hematopoiesis and vascular growth
Patent Number: 6713065This patent covers the use of hedgehog proteins for stimulation of hematopoiesis and angiogenesis. The hedgehog proteins are critically involved in embryogenesis and developmental biology. Given the numerous similarities between stem cells and embryonic cells in general, the notion that hematopoietic stem cells still respond to embryonic signals is intriguing.
Method for promoting hematopoietic and mesenchymal cell proliferation and differentiation
Patent Number: 6335195This patent teaches that angiotensinogen I, II, and analogues thereof, are useful for the stimulation of mesenchymal and/or hematopoietic stem cell proliferation and/differentiation.
Isoprenoid pathway inhibitors for stimulating bone growth
Patent Number: 6642216This patent covers inhibitors of the isoprenoid pathway which can be used for stimulation of osteoblast and other bone stem cells in order to stimulate growth of bone.
Hemoregulatory compounds
Patent Number: 6077857This patent provides compositions of matter that stimulate hematopoietic stem cell proliferation. These compounds appear to be small molecules and have an acceptable safety profile in the data provided.
TGF.beta.1 responsive bone marrow derived cells to express a recombinant protein
Patent Number: 6063593This patent teaches that tranforming growth factor beta treatment of hematopoietic stem cells will make them more susceptible to gene transfection.