Class: Expansion (424)
Method for repopulating human bone marrow comprising culturing CD34+ cells in a serum free medium
Patent Number: 6372210This patent provides tissue culture media and conditions for expansion and growth of hematopoietic cells in vitro. Specifically, this patent is useful for cellular therapy in which the media for growing and maintaining the stem cells has to be chemically defined and effective.
Method for repopulating human bone marrow comprising culturing CD34+ cells in a serum free medium
Patent Number: 6224860This patent provides a culture media that can be used for the expansion of hematopoietic stem cells in vivo for use in transplantation.
Method for culturing CD34.sup.+ cells in a serum-free medium
Patent Number: 5945337This patent covers the composition of matter for several types of tissue culture media that are useful for ex vivo expanding stem cells in absence of various forms of serum. This is useful for clinical purposes since administration of cells grown in serum is not looked upon favorably by regulatory agencies.
Method for modulating smooth muscle cell proliferation
Patent Number: 6114311This patent covers promoters of smooth muscle cells, as well as promoters found in the stem cells for smooth muscle cells. The invention teaches how to use these promoters to treat various conditions ranging from restenosis to asthma.
Use of IGF-I for the treatment of kidney disorders
Patent Number: 5985830This patent teaches that Insulin Like Growth Factor-1 is useful for the treatment of polycystic kidney disease. Given the stimulatory effects of this hormone on stem cells, it is interesting to see if this patent can be used with exogenous stem cell therapy.
Method for promoting hematopoiesis
Patent Number: 6596688This patent teaches that administration of the pregnancy associated compound human chorionic gonadotropin can stimulate hematopoietic stem cells. This patent is interesting in light of clinical trials that are ongoing by Stem Cell Therapeutics Inc that use hCG in combination with other compounds for post-stroke regeneration of neurons.
Therapeutic polypeptides from .beta.-hCG and derivatives
Patent Number: 6583109This patent covers derivatives of the human chorionic gonadotrophin, as well as hCG itself, for the stimulation of hematopoiesis, reduction of cancer, and reduction of HIV.
Hematopoietic stem cell growth factor (SCGF)
Patent Number: 6541217This patent covers a cytokine that is able to stimulate proliferation of hematopoietic stem cells. It is unclear what the modern name of this cytokine is. This patent may be very useful for development of a stem cell pharmaceutical.
Uses of Wnt polypeptides
Patent Number: 6159462This patent provides composition of matter for various peptides that are derived frim Wnt that are capable of stimulating stem cell expansion.
Method of enhancing proliferation or differentiation of hematopoietic stem cells using Wnt polypeptides
Patent Number: 5851984Wnt peptides are critical in embryonic development and cell fate determination. In this patent Wnt peptides are used for the expansion and differentiation of hematopoietic stem cells. I predict that these peptides would also be useful for expansion of non-hematopoietic stem cells as well.