Patents
Vitro maintenance of hematopoietic stem cells
Patent Number: 6030836This patent covers expansion of hematopoietic stem cells by culturing with allogeneic or autologous mesenchymal stem cells.
Inventors: Thiede, Mark A. (Forest Hill, MD); Pittenger, Mark F. (Severna Park, MD); Mbalaviele, Gabriel (Columbia, MD)
Assignee: Osiris Therapeutics, Inc. (Baltimore, MD)
Date of First Priority Issue: Monday June 8th, 1998
Guided development and support of hydrogel-cell compositions
Patent Number: 6027744This patent covers ways generating tissue implants and artificial tissues in vitro for in vivo implantation.
Inventors: Vacanti, Charles A. (Worcester, MA); Vacanti, Joseph P. (Worcester, MA)
Assignee: University of Massachusetts Medical Center (Boston, MA); The Children's Medical Center Corporation (Boston, MA)
Date of First Priority Issue: Friday April 24th, 1998
Three-dimensional culture of pancreatic parenchymal cells cultured living stromal tissue prepared in vitro
Patent Number: 6022743This patent teaches the three dimensional generation of artificial pancreatic grafts using a proprietary culture system that is described in detail.
Inventors: Naughton, Gail K. (Del Mar, CA); Naughton, Brian A. (El Cajon, CA)
Assignee: Advanced Tissue Sciences, Inc. (La Jolla, CA)
Date of First Priority Issue: Friday April 18th, 1986
Ligands that modulate differentiation of mesenchymal stem cells
Patent Number: 6022540This patent covers the induction of mesenchymal stem cell differentiation by activation of a ligand called ALCAM. Mesenchymal stem cells can differentiate into a wide variety of non-hematopoietic tissues and are useful for many clinical applications since they can be transplanted across allogeneic barriers, therefore knowing how to modulate their differentiation programs is very useful.
Inventors: Bruder, Scott P. (Owings Mills, MD); Jaiswal, Neelam (Ellicott City, MD)
Assignee: Osiris Therapeutics, Inc. (Baltimore, MD)
Date of First Priority Issue: Thursday September 4th, 1997
Method for production of neuroblasts
Patent Number: 6020197This patent covers the induction of differentiation of neural stem cells into various committed neuronal lineages. The patent provides FGF-2 for expansion of neural cells and stem cells, as well it provides various oncogenes which may be used for their immortalization.
Inventors: Gage, Fred H. (La Jolla, CA); Ray, Jasodhara (San Diego, CA)
Assignee: The Regents of the University of California (Oakland, CA)
Date of First Priority Issue: Wednesday January 6th, 1993
Methods for treatment of pulmonary disease using GM-CSF
Patent Number: 6019965This patent teaches that the administration of the clinically-used cytokine GM-CSF is useful for the treatment of alveolar proteinosis. This patent would be great to use in combination with systemically administered stem cell therapy since most stem cells given intravenously end up in either the lung or the liver.
Inventors: Dunn, Ashley Roger (Parkville, AU); Stanley, Edouard Guy (London, GB); Lieschke, Graham John (Parkville, AU); Grail, Dianne (Parkville, AU); Fowler, Kerry J. (Parkville, AU)
Assignee: Ludwig Institute for Cancer Research (New York, NY)
Date of First Priority Issue: Monday October 24th, 1994
Myocardial grafts and cellular compositions
Patent Number: 6015671This patent teaches how to extract specific cells from a population of stem cells that are differentiating.
Inventor: Field, Loren J. (Indianapolis, IN)
Assignee: Indiana University Foundation (Bloomington, IN)
Date of First Priority Issue: Wednesday June 7th, 1995
Methods for increasing hematopoietic cells
Patent Number: 6013067This patent teaches to treat a hematopoietic stem cell donor with thrombopoietic, collect the "activated" stem cells, and infuse them into a recipient. In some situations the recipient may also be given thrombopoietin.
Inventors: Fibbe, Willem E. (Lisse, NL); Grossman, Angelika (Seattle, WA)
Assignee: ZymoGenetics, Inc. (Seattle, WA)
Date of First Priority Issue: Wednesday June 7th, 1995
Intrapulmonary delivery of hematopoietic drug
Patent Number: 6012450This patent teaches the administration of hematopoietic stem cell stimulatory factors through the intrapulmonary route. This patent is interesting in light of the fact that exogenous stem cells generally go to the liver or lung.
Inventor: Rubsamen, Reid M. (Berkeley, CA)
Assignee: Aradigm Corporation (Hayward, CA)
Date of First Priority Issue: Tuesday March 5th, 1991
Method of cloning bovines using reprogrammed non-embryonic bovine cells
Patent Number: 6011197This patent teaches methods of cloning cattle.
Inventors: Strelchenko, Nikolai S. (DeForest, WI); Betthauser, Jeffrey M. (Windsor, WI); Jurgella, Gail L. (Madison, WI); Pace, Marvin M. (DeForest, WI); Bishop, Michael D. (Rio, WI)
Assignee: Infigen, Inc. (Deforest, WI)
Date of First Priority Issue: Thursday March 6th, 1997