Patents
Methods and kits for stimulating production of megakaryocytes and thrombocytes
Patent Number: 6051415C reactive protein is produced by the liver in times of inflammation. This patent discloses various mutants of CRP that are capable of stimulating production of increased platelets. Given that TPO, another agent that stimulates platelet production, can stimulate self renewal of primitive hematopoietic stem cells, it would be interesting to see if these CRP mutants have similar activity.
Inventor: Potempa, Lawrence A. (Deerfield, IL)
Assignee: Immtech International, Inc. (Evanston, IL)
Date of First Priority Issue: Wednesday February 23rd, 1994
Therapeutic uses of interleukin-3 (IL-3) multiple mutation polypeptides
Patent Number: 6051217This patent provides compositions of matter for various forms of the cytokine IL-3. Uses of IL-3 such as stimulation of hematopoiesis are described. Since myeloid suppressor cells express the IL-3 receptor, it may be interesting to see if IL-3 can actually mediate immune suppressive functions.
Inventors: Bauer, S. Christopher (New Haven, MO); Abrams, Mark Allen (St. Louis, MO); Braford-Goldberg, Sarah Ruth (St. Louis, MO); Caparon, Maire Helena (Chesterfield, MO); Easton, Alan Michael (Maryland Heights, MO); Klein, Barbara Kure (St. Louis, MO); McKearn, J
Assignee: G. D. Searle & Co. (Chicago, IL)
Date of First Priority Issue: Saturday November 14th, 1992
Apparatus and methods for preparing an implantable graft
Patent Number: 6049026This patent provides methods of administering stem cells after differentiating them into bioartificial bone.
Inventor: Muschler, George Frederick (Cleveland Heights, OH)
Assignee: The Cleveland Clinic Foundation (Cleveland, OH)
Date of First Priority Issue: Monday June 3rd, 1996
Bioreactor for mammalian cell growth and maintenance
Patent Number: 6048721This patent provides new devices and culture conditions for expanding stem cells of the hematopoietic lineage ex vivo. This patent has actually been used for development of technologies that were used in clinical trials.
Inventors: Armstrong, R. Douglas (Ann Arbor, MI); Maluta, James (Dexter, MI); Roecker, David (Denver, CO)
Assignee: Aastrom Biosciences, Inc. (Ann Arbor, MI)
Date of First Priority Issue: Wednesday June 7th, 1995
Method for production of neuroblasts
Patent Number: 6045807This patent teaches how to make immortalized neurons through differentiation of neuronal stem cells and then transfection with various genes. These immortalized cell lines can subsequently be used for treatment of neurodegenerative conditions.
Inventors: Gage, Fred H. (La Jolla, CA); Ray, Jasodhara (San Diego, CA)
Assignee: The Regents of the University of California (Oakland, CA)
Date of First Priority Issue: Wednesday January 6th, 1993
Antibody recognizing a small subset of human hematopoietic cells
Patent Number: 6043348This patent covers a new marker of hematopoietic stem cells. This marker can be used for extraction of these stem cells, as well as for quantification. The protein marker is called "MG-1" in the specification.
Inventors: Lawman, Michael J. P. (Gainesville, FL); Lawman, Patricia (Gainesville, FL)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Wednesday November 13th, 1996
Cell culture media for mammalian cells
Patent Number: 6043092This patent covers a specific tissue culture media that is useful for the expansion of hepatocytes. The media is a serum free media and can be used for clinical applications.
Inventor: Block, Geoffrey D. (Pittsburgh, PA)
Assignee: University of Pittsburgh (Pittsburgh, PA)
Date of First Priority Issue: Monday March 18th, 1996
In vitro generation of differentiated neurons from cultures of mammalian multipotential CNS stem cells
Patent Number: 6040180This patent teaches that by manipulating divalent ion content of a tissue culture media, it is possible to modify the differentiation program of neuronal stem cells. Various methods of inducing differentiation of such neuronal stem cells into neurons, astrocytes, and oligodendrocytes are disclosed.
Inventor: Johe, Karl K. (Potomac, MD)
Assignee: NeuralStem Biopharmaceuticals, Ltd. (College Park, MD)
Date of First Priority Issue: Thursday May 23rd, 1996
Preparation of serum-free suspensions of human hematopoietic cells or precursor cells
Patent Number: 6037174This is a patent on generation of neutrophil precursors and their expansion ex vivo. It may be interesting to use a patent such as this to generate allogeneic neutrophils for short term use after chemotherapy for patients that are immunocompromised so that they do not get infections. The question is whether administration of such allogeneic neutrophils would cause nephritis by virtue of...
Inventors: Smith, Stephen L. (Arlington Heights, IL); Qiao, Xiaoying (Waukegan, IL); Maciukas, Susan M. (El Cerrito, CA); Loudovaris, Maureen F. (Grayslake, IL); Bender, James G. (Lindenhurst, IL); Van Epps, Dennis (Cary, IL)
Assignee: Nexell Therapeutics, Inc. (Irvine, CA)
Date of First Priority Issue: Monday August 23rd, 1993
Methods for differentiating neural stem cells to glial cells using neuregulins
Patent Number: 6033906This patent covers ways of generating glial cells in vitro for in vivo use. Several growth factors and culture conditions are provided.
Inventor: Anderson, David J. (Altadena, CA)
Assignee: California Institute of Technology (Pasadena, CA)
Date of First Priority Issue: Monday July 26th, 1993