Patents
Methods for use of Mpl ligands with primitive human hematopoietic stem cells
Patent Number: 6060052This patent teaches ways of using thrombopoietin or other ligands of MPL in order to stimulate proliferation of early hematopoietic stem cells. Since thrombopoietin is used in numerous stem cell expansion cocktails, this patent is very important.
Inventors: Murray, Lesley J. (San Jose, CA); Young, Judy C. (San Carlos, CA)
Assignee: SyStemix, Inc. (Palo Alto, CA)
Date of First Priority Issue: Monday October 30th, 1995
Systems for processing and storing placenta/umbilical cord blood
Patent Number: 6059968Methods and devices are disclosed that enable efficient collection and storage of cord blood.
Inventor: Wolf, Jr., Ludwig (Inverness, IL)
Assignee: Baxter International Inc. (Deerfield, IL)
Date of First Priority Issue: Tuesday January 20th, 1998
Stem cell inhibiting proteins
Patent Number: 6057123This patent provides analogues of chemokines that are capable of inhibiting proliferation of hematopoietic stem cells.
Inventors: Craig, Stewart (Oxford, GB); Hunter, Michael George (Buckinghamshire, GB); Edwards, Richard Mark (Oxford, GB); Czaplewski, Lloyd George (Oxford, GB); Gilbert, Richard James (Oxford, GB)
Assignee: British Biotech Pharmaceuticals Limited (Oxford, GB)
Date of First Priority Issue: Wednesday December 23rd, 1992
Method and device for regenerating cartilage in articulating
Patent Number: 6056777This patent provides medical devices useful for the treatment of cartilage injury. Stem cells may be differentiated into cartilage and used in combination with this invention.
Inventor: McDowell, Charles L. (Richmond, VA)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Friday February 27th, 1998
Hemoregulatory compounds
Patent Number: 6054465Small molecule compounds are provided that stimulate hematopoietic stem cell proliferation. It would be interesting to see whether these compounds have selective stimulatory capability towards normal versus leukemic hematopoietic stem cells.
Inventors: Bhatnagar, Pradip Kumar (Exton, PA); Heerding, Dirk Andries (Malvern, PA)
Assignee: SmithKline Beecham Corporation (Philadelphia, PA)
Date of First Priority Issue: Monday November 13th, 1995
Methods and compositions for modulation and inhibition of telomerase in vitro
Patent Number: 6054442This patent discloses small molecules that modulate activity of telomerase. On the one hand telomerase inhibition is useful for cancer therapy, on the other activation of telomerase is useful for longevity purposes.
Inventors: Chen, Shih-Fong (San Antonio, TX); Maine, Ira (San Antonio, TX); Kerwin, Sean M. (Round Rock, TX); Fletcher, Terace M. (San Antonio, TX); Salazar, Miguel (Austin, TX); Mamiya, Blain (Austin, TX); Windle, Bradford E. (San Antonio, TX); Wajima, Makoto (San
Assignee: Board of Regents, University of Texas System (Austin); CTRC Research Foundation (San Antonio, TX)
Date of First Priority Issue: Thursday July 6th, 1995
Oxypurine nucleosides and their congeners, and acyl derivatives thereof, for improvement of hematopoiesis
Patent Number: 6054441This patent covers small molecule stimulators of hematopoietic stem cell activity. These molecules appear to have a reasonable safety profile and are interesting for clinical development. One area of development may be their use in combination with cord blood transplants in adults...since cord blood transplants usually take a longer time to reconstitute.
Inventors: von Borstel, Reid W. (Potomac, MD); Bamat, Michael K. (Potomac, MD); Hiltbrand, Bradley M. (Columbia, MD); Butler, James C. (Gaithersburg, MD); Shirali, Shyam (Gaithersburg, MD)
Assignee: Pro-Neuron, Inc. (Rockville, MD)
Date of First Priority Issue: Monday June 5th, 1995
Biocompatible devices with foam scaffolds
Patent Number: 6054142This patent provides scaffolds that can be seeded with stem cells and subsequently inplanted for regeneration of various tissues.
Inventors: Li, Rebecca (Canton, MA); Hazlett, Tyrone F. (Coventry, RI)
Assignee: Cyto Therapeutics, Inc. (Lincoln, RI)
Date of First Priority Issue: Thursday August 1st, 1996
Modulation of immune responses in blood-borne mesenchymal cells
Patent Number: 6054121If I read this currently, this patent seems to cover the use of blood mesenchymal stem cells for stimulation of immune responses to antigens. This is the opposite to what the current knowledge of mesenchymal stem cells is...that being that they are immune suppressive. If these cells were immune stimulatory then the current Phase III trials for graft versus host disease that Osiris is doing would...
Inventors: Cerami, Anthony (Shelter Island, NY); Bucala, Richard J. (New York, NY)
Assignee: The Picower Institute for Medical Research (Manhasset, NY)
Date of First Priority Issue: Friday February 26th, 1993
Methods of enhancing functioning of the upper gastrointestinal tract
Patent Number: 6051557This patent covers the use of GLP-2 for stimulation of stem cells in the upper GI tract. This patent is useful for treatment of pathologies associated with malfunction of these cells, such as mucositis, gastritis, or various types of injuries.
Inventor: Drucker, Daniel J. (Ontario, CA)
Assignee: 1149336 Ontario Inc. (Toronto, CA)
Date of First Priority Issue: Friday May 16th, 1997