Patents
Infusion of neutrophil precursors for treatment of neutropenia
Patent Number: 6010697This patent teachs ways of overcoming neutropenia by administration of committed stem cells that differentiate into the neutrophil lineage. This work has the potential to be very beneficial in nuclear accidents where a quick supply of neutrophils is needed. The biggest barrier is whether allogeneic neutrophil committed stem cells may be used or whether the stem cells strictly have to be...
Inventors: Smith, Stephen L. (Arlington Heights, IL); Qiao, Xiaoying (Waukegan, IL); Maciukas, Susan M. (El Cerrito, CA); Loudovaris, Maureen F. (Grayslake, IL); Bender, James G. (Lindenhurst, IL); Van Epps, Dennis E. (Cary, IL)
Assignee: Nexell Therapeutics, Inc. (Irvine, CA)
Date of First Priority Issue: Monday August 23rd, 1993
Enhancing hematopoietic progenitor cell engraftment using mesenchymal stem cells
Patent Number: 6010696This patent covers the administration of mesenchymal stem cells as "facilitator cells" such that engraftment of hematopoietic stem cells is accelerated. Mesenchymal stem cells may play this engraftment assisting role due to the wide variety of growth factors that they are known to produce.
Inventors: Caplan, Arnold I. (Cleveland Heights, OH); Haynesworth, Stephen E. (Cleveland Heights, OH); Gerson, Stanton L. (Pepper Pike, OH); Lazarus, Hillard M. (Shaker Heights, OH)
Assignee: Osiris Therapeutics, Inc. (Baltimore, MD)
Date of First Priority Issue: Friday November 16th, 1990
System for the in vivo delivery and expression of heterologous genes in the bone marrow
Patent Number: 6008035This patent covers a method of generating viruses that are useful for transfection in living beings. Specifically the viral approaches can be used to target bone marrow stem cells.
Inventors: Johnston, Robert E. (Chapel Hill, NC); Davis, Nancy L. (Chapel Hill, NC); Simpson, Dennis A. (Pittsboro, NC)
Assignee: The University of North Carolina at Chapel Hill (Chapel Hill, NC)
Date of First Priority Issue: Wednesday February 19th, 1997
Method of freezing cells and cell-like materials
Patent Number: 6007978This patent covers methods of freeze-drying various cells, including stem cells.
Inventors: Goodrich, Jr., Raymond P. (Pasadena, CA); Coker, Samuel O. S. (South Pasadena, CA); Arnaud, Francoise (Pasadena, CA); Hackett, Roger W. (Pasadena, CA)
Assignee: COBE Laboratories, Inc. (Lakewood, CO)
Date of First Priority Issue: Wednesday May 18th, 1988
Methods of inducing immunity using low molecular weight immune stimulants
Patent Number: 6007819This patent covers a small molecular weight family of compounds that directly stimulate hematopoietic stem cell proliferation but at the same time have immune augmentative effects. Such compounds are especially useful after bone marrow transplantation for leukemias or cancers since post transplantation it is not only enough to have restored hematopoiesis, but augmentation of the immune system...
Inventors: Taub, Floyd (Silver Spring, MD); Perun, Thomas J. (Round Lake, IL); Murray, Christopher K. (Longmont, CO); Daughenbaugh, Randall J. (Longmont, CO); Lednicer, Daniel (Rockville, MD)
Assignee: Dovetail Technologies, Inc. (College Park, MD)
Date of First Priority Issue: Tuesday October 17th, 1995
Liver parenchymal cells having clonal growth ability, method for obtaining same, method for subculturing same, and subculturing system of primary hepatocytes
Patent Number: 6004810This patent covers a type of liver stem cell that is useful for the treatment of various hepatic diseases. It will be interesting to compare this patent to the other ones in this directory that cover liver stem cells.
Inventors: Tateno, Chise (Hiroshima, JP); Yoshizato, Katsutoshi (Hiroshima, JP)
Assignee: Research Development Corporation of Japan (Saitama, JP)
Date of First Priority Issue: Tuesday April 11th, 1995
Analogs of pluripotent granulocyte colony-stimulating factor
Patent Number: 6004548This patent covers hematopoietic stem cell stimulatory peptides and proteins that are analogs of pluripotent G-CSF. These compounds are useful for stimulation of hematopoiesis after ablation with radiotherapy or chemotherapy.
Inventor: Souza, Lawrence M. (Thousand Oaks, CA)
Assignee: Amgen, Inc. (Thousand Oaks, CA)
Date of First Priority Issue: Friday August 23rd, 1985
Methods for differentiating neural stem cells to neurons or smooth muscle cells using TGT-.beta. super family growth factors
Patent Number: 6001654This patent teaches how to induce the differentiation of neural stem cells into either neurons or smooth muscle cells by treatment with proteins that belong to the transforming growth factor beta superfamily.
Inventors: Anderson, David J. (Altadena, CA); Shah, Nirao M. (New York, NY)
Assignee: California Institute of Technology (Pasadena, CA)
Date of First Priority Issue: Monday July 27th, 1992
In vitro growth of functional islets of Langerhans and in vivo uses thereof
Patent Number: 6001647This patent teaches how to expand populations of islet cells in vitro for possible in vivo use in the treatment of type 1 diabetes. This technology seems very exciting, however the patent has some priority claims more than a decade ago and to our knowledge this therapy has yet to be clinically implimented.
Inventors: Peck, Ammon B. (Gainesville, FL); Cornelius, Janet G. (Gainesville, FL)
Assignee: Ixion Biotechnology, Inc. (Alachua, FL)
Date of First Priority Issue: Thursday April 28th, 1994
Resurfacing cartilage defects with chondrocytes proliferated without differentiation using platelet-derived growth factor
Patent Number: 6001352This patent teaches the use of platelet derived growth factor for stimulating proliferation of chondrocyte and chondrocyte stem cells along the area of a joint defect, so as to accelerate healing.
Inventors: Boyan, Barbara D. (San Antonio, TX); Schwartz, Zvi (Jerusalem, IL)
Assignee: OsteoBiologics, Inc. (San Antonio, TX)
Date of First Priority Issue: Monday March 31st, 1997