Patents
Ex-vivo expansion of stem cells using combinations of interleukin-3 (IL-3) variants and other cytokines
Patent Number: 5997860This patent covers IL-3 and various deviations of it, in combination with other hematopoietic stem cell stimulatory cytokines for acceleration of hematopoietic recovery after stem cell transplantation. This patent is useful in situations in which the stem cell dose administered may be relatively low, such as cord blood transplants given to adult recipients.
Inventors: Bauer, S. Christopher (New Haven, MO); Abrams, Mark Allen (St. Louis, MO); Braford-Goldberg, Sarah Ruth (St. Louis, MO); Caparon, Maire Helena (Chesterfield, MO); Easton, Alan Michael (Maryland Heights, MO); Klein, Barbara Kure (St. Louis, MO); McKearn, J
Assignee: G. D. Searle & Co. (Chicago, IL)
Date of First Priority Issue: Tuesday November 24th, 1992
Method of producing a polypeptide having human granulocyte colony stimulating factor activity
Patent Number: 5994518This patent covers ways of generating a molecule that has granulocyte colony stimulating activity. It may be that this molecule is similar to G-CSF which is currently sold as "Neupogen" by the company Amgen.
Inventors: Kuga, Tetsuro (Yamaguchi, JP); Miyaji, Hiromasa (Tokyo, JP); Sato, Moriyuki (Tokyo, JP); Okabe, Masami (Shizuoka, JP); Morimoto, Makoto (Shizuoka, JP); Itoh, Seiga (Kanagawa, JP); Yamasaki, Motoo (Tokyo, JP); Yokoo, Yoshiharu (Kanagawa, JP); Yamaguchi, Ka
Assignee: Kyowa Hakko Co., Ltd (JP)
Date of First Priority Issue: Tuesday December 22nd, 1987
Gene therapy using stromal cells
Patent Number: 5993801This patent covers transfection of stromal cells with therapeutic genes and administering the transfected cells into a recipient in need of therapy. It is interesting to see if these stromal cells have a similar phenotype as the mesenchymal stem cells that Osiris has patents on.
Inventors: Greenberger, Joel S. (Lincoln, MA); Levine, Peter H. (Worcester, MA)
Assignee: ALG Company (Marlboro, MA)
Date of First Priority Issue: Thursday February 2nd, 1989
Apparatus and method for collecting blood from an umbilical cord
Patent Number: 5993429This patent anticipated the cord blood revolution and therefore claimed various devices and methods of collection of cord blood. Stem cells purified from cord blood are currently used for a variety of hematological and non-hematological disorders.
Inventors: Kuypers, Franciscus A. (El Cerrito, CA); Cole, Robert B. (Alamo, CA); Meyst, Richard P. (Valley Center, CA); Gorton, Lanny A. (San Diego, CA); Wright, James I. (Villa Park, CA)
Assignee: Childen's Hospital Medical Center of Northern California (Oakland, CA)
Date of First Priority Issue: Tuesday May 14th, 1996
Computer-based mixed-use registry of placental and umbilical cord stem cells
Patent Number: 5993387This patent in a way smells like a method of doing business patent. Interestingly it was actually filed before the "State Street v Signature Financial" case. Essentially this patent covers a computer registry for matching cord blood to donors. I wonder if this patent is actually being enforced today?
Inventors: Moore, Thomas Eldon (Los Altos Hills, CA); Harris, David Thomas (Tucson, AZ); Kramer, Jesse O. (San Francisco, CA)
Assignee: Core Blood Registry, Inc. (San Bruno, CA)
Date of First Priority Issue: Thursday August 14th, 1997
Methods for stimulating granulocyte/macrophage lineage using thrombopoietin
Patent Number: 5989537As the name "thrombopoietin" implies, this cytokine is conventionally viewed as a stimulator of platelet production. In this patent the use of thrombopoietin for stimulation of the granulocytic/monocytic lineage is claimed. Currently numerous companies are developing agonists and agonistic antibodies of the thrombopoietin receptor.
Inventors: Holly, Richard D. (Seattle, WA); Lok, Si (Seattle, WA); Foster, Donald C. (Seattle, WA); Hagen, Frederick S. (Seattle, WA); Kaushansky, Kenneth (Woodinville, WA); Kuijper, Joseph L. (Bothell, WA); Lofton-Day, Catherine E. (Brier, WA); Oort, Pieter J. (Sea
Assignee: ZymoGenetics, Inc. (Seattle, WA); University of Washington (Seattle, WA)
Date of First Priority Issue: Monday March 21st, 1994
Human haemopoietic maturation factor polypeptides
Patent Number: 5986069This patent covers peptides that inhibit HELA cell proliferation, but are stimulatory to T cells and hematopoietic stem cells.
Inventors: Kirkness, Ewen F. (Olney, MD); Adams, Mark D. (North Potomac, MD); Olsen, Henrick S. (Gaithersburg, MD); Rosen, Craig A. (Laytonsville, MD)
Assignee: Human Genome Sciences, Inc. (Rockville, MD)
Date of First Priority Issue: Tuesday January 25th, 1994
Use of IGF-I for the treatment of kidney disorders
Patent Number: 5985830This patent teaches that Insulin Like Growth Factor-1 is useful for the treatment of polycystic kidney disease. Given the stimulatory effects of this hormone on stem cells, it is interesting to see if this patent can be used with exogenous stem cell therapy.
Inventors: Acott, Philip D. (Halifax, CA); Crocker, John F. S. (Halifax, CA)
Assignee: Dalhousie University (Halifax, CA)
Date of First Priority Issue: Monday September 16th, 1996
Embryonic stem cell lines obtained from C3H/HeN and DBA/1J mouse strains
Patent Number: 5985659This patent provides some embryonic stem cell lines derived from mice that are useful for the creation of knockout animals.
Inventors: Kusakabe, Moriaki (Ibaragi, JP); Kamon, Toshio (Tokyo, JP)
Assignee: The Institute of Physical and Chemical Research (Saitama, JP)
Date of First Priority Issue: Tuesday May 21st, 1996
Suppressor and progenitor cells
Patent Number: 5985656This patent covers a type of bone marrow immune suppressive cell that appears to be related to what is currently called the NKT cell. This suppressor cell may also be related to the classical "natural suppressor cell" which is a myeloid progenitor with immune suppressive properties. The cells in this patent are useful for the treatment of autoimmunity and transplant rejection.
Inventor: Strober, Samuel S. (Portola Valley, CA)
Assignee: The Board of Trustees of the Leland Stanford Junior University (Stanford, CA)
Date of First Priority Issue: Thursday June 12th, 1986