Patents
Stem cell proliferation factor
Patent Number: 5981708This patent covers a cytokine whose modern name is not known from reading the patent. The cytokine is capable of stimulating expansion of CD34+ human hemapoietic stem cells.
Inventors: Lawman, Michael J. P. (Gainesville, FL); Lawman, Patricia D. (Gainesville, FL); Denslow, Nancy D. (Gainesville, FL)
Assignee: University of Florida (Gainesville, FL)
Date of First Priority Issue: Thursday October 6th, 1983
Epidermal differentiation factor
Patent Number: 5981220This patent covers a protein that stimulates stem cell differentiation into epidermal cells. The protein is useful for a variety of regenerative purposes, either alone or in combination with exogenous stem cells.
Inventors: Ni, Jian (Rockville, MD); Feng, Ping (Gaithersburg, MD); Dillon, Patrick J. (Gaithersburg, MD); Gentz, Reiner (Silver Spring, MD)
Assignee: Human Genome Sciences, Inc. (Rockville, MD)
Date of First Priority Issue: Wednesday March 27th, 1996
Maintaining cells for an extended time by entrapment in a contracted matrix
Patent Number: 5981211This patent teaches how to grow cells outside of the body but in chambers that can be connected to an extracorporeal set up. In one particular embodiment this patent may be used for the generation of an artificial liver.
Inventors: Hu, Wei-Shou (Falcon Heights, MN); Cerra, Frank Bernard (Edina, MN); Nyberg, Scott Lyle (St. Louis Park, MN); Scholz, Matthew Thomas (Woodbury, MN); Shatford, Russell A. (Minneapolis, MN)
Assignee: Regents of the University of Minnesota (Minneapolis, MN)
Date of First Priority Issue: Thursday May 18th, 1989
In vitro induction of dopaminergic cells
Patent Number: 5981165This patent teaches how to generate in vitro neurons that produce dopamine. The neurons are generated from stem cells through culture in FGF and TGF beta family members, as well as in the presence of feeder cell layers.
Inventors: Weiss, Samuel (Alberta, CA); Reynolds, Brent (Alberta, CA)
Assignee: NeuroSpheres Holdings Ltd. (Calgary, CA)
Date of First Priority Issue: Monday July 8th, 1991
Methods for enhancing angiogenesis with endothelial progenitor cells
Patent Number: 5980887This patent covers the use of various endothelial stem cells, and stem cells that resemble hematopoietic stem cells, for the stimulation of angiogenesis. Cell types covered include: CD34+, Tie+, or flk-1+. Methods of expanding the cells in vitro prior to implantation are also disclosed.
Inventors: Isner, Jeffrey M. (Weston, MA); Asahara, Takayuki (Arlington, MA)
Assignee: St. Elizabeth's Medical Center of Boston (Boston, MA)
Date of First Priority Issue: Friday November 8th, 1996
Recombinant vectors for reconstitution of liver
Patent Number: 5980886This patent covers ways of transfecting liver cells in vivo through the induction of liver stem cell activation by first transfection with a gene such as tPA or uPA, and then once the cells are proliferating, transfection with another gene that is therapeutic.
Inventors: Kay, Mark A. (Seattle, WA); Lieber, Andre (Seattle, WA)
Assignee: University of Washington (Seattle, WA)
Date of First Priority Issue: Wednesday December 14th, 1994
Growth factor-induced proliferation of neural precursor cells in vivo
Patent Number: 5980885This patent teaches the in vivo expansion of neural stem cells through administration of fibroblast growth factor in combination with an agent selected from the group comprising of: EGF, TGF, and amphiregulin. This patent is useful for the treatment of degenerative nervous system diseases alone, or in combination with exogenously administered stem cells.
Inventors: Weiss, Samuel (Alberta, CA); Reynolds, Brent (Alberta, CA)
Assignee: NeuroSpheres Holdings Ltd. (Calgary, CA)
Date of First Priority Issue: Monday July 8th, 1991
Bone precursor cells: compositions and methods
Patent Number: 5972703This patent teaches the isolation, expansion, and use of bone stem cells that are separated from bone marrow cells.
Inventors: Long, Michael W. (Northville, MI); Mann, Kenneth G. (Shelburne, VT)
Assignee: The Regents of the University of Michigan (Ann Arbor, MI)
Date of First Priority Issue: Friday August 12th, 1994
Human CNS neural stem cells
Patent Number: 5968829This patent provides a type of neural stem cells, including stem cells derived from the basal forebrain. Disclosed are methods of maintaining the neural stem cells in culture, as well as ways of differentiating them into neurons.
Inventor: Carpenter, Melissa (Lincoln, RI)
Assignee: Cytotherapeutics, Inc. (Providence, RI)
Date of First Priority Issue: Friday September 5th, 1997
Keratinocyte culture from precursor cells
Patent Number: 5968546This patent provides compositions for treatment of skin defects, including burn wounds, through culture and diffentiation of keratinocyte stem cells, and subsequent administration of the keratinocyte stem cells in vivo.
Inventors: Baur, Marcus (CH-1066 Epalinges, CH); Hunziker, Thomas (CH-3653 Oberhofen, CH); Limat, Alain (CH-1712 Tafers, CH); Riedel, Wolfram (D-869198 Utting, DE); Toloczyki, Christian (D-86919 Utting, DE)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Friday May 16th, 1997