Patents
Method of promoting hematopoiesis using derivatives of human chorionic gonadotropin
Patent Number: 5968513This patent teaches that the pregnancy associated protien hCG is a stimulator of hematopoiesis. This is an interesting concept since numerous cancers actually secrete hCG. I wonder if during pregnancy, or cancer, there is a high enough gradient of hCG to stimulate hematopoiesis. It is known that pregnant mice have an increase in spleen size, I wonder if the hCG has anything to do with this?
Inventors: Gallo, Robert C. (Bethesda, MD); Bryant, Joseph (Rockville, MD); Lunardi-Iskandar, Yanto (Gaithersburg, MD)
Assignee: University of Maryland Biotechnology Institute (College Park, MD)
Date of First Priority Issue: Monday June 24th, 1996
Hepatocyte growth factor--induced proliferation and differentiation of erythroid cells
Patent Number: 5968501This patent covers the use of HGF for stimulation of hematopoietic stem cell proliferation, as well as differentiation along the erythroid lineage. This patent may be useful for the treatment of anemia, as well as post hematopoietic stem cell ablation patients.
Inventor: Comoglio, Paolo (Turin, IT)
Assignee: Dompe S.p.A. (IT)
Date of First Priority Issue: Thursday November 24th, 1994
Methods of screening for a candidate compound able to bind to CD34.sup.+ cells
Patent Number: 5965457This patent covers methods of screening for identifying which compounds bind to purified CD34+ cells. Since CD34+ cells are stem cells of the hematopoietic lineage, by identifying agents that bind to them it is possible to generate novel ways of purifying and identifying them.
Inventor: Magnani, John L. (Rockville, MD)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Tuesday June 6th, 1995
Method of screening a compound for hematopoietic activity
Patent Number: 5965437This patent teaches the in vitro purification of early hematopoietic stem cells by killing of the mature ones. This is performed through addition of a hematopoietic growth factor, together with a cytotoxic agent that only kills dividing cells. The hematopoietic stem cells that are very primitive will not be killed since the primitive hematopoietic stem cells do not undergo division very...
Inventor: Scadden, David T. (Weston, MA)
Assignee: Beth Israel Deaconess Medical Center, Inc. (Boston, MA)
Date of First Priority Issue: Thursday September 1st, 1994
Method of isolating mesenchymal stem cells associated with isolated megakaryocytes by isolating megakaryocytes
Patent Number: 5965436This patent teaches that mesenchymal stem cells in the bone marrow are sometimes found in attachment to megakaryocytes. The patent teaches that it is possible to extracted megakaryocytes from the bone marrow, using antibodies such as anti-CD41, and then from the megakaryocytes to de-attach the mesenchymal stem cells.
Inventors: Thiede, Mark A. (Forest Hills, MD); Marshak, Daniel R. (Lutherville, MD)
Assignee: Osiris Therapeutics, Inc. (Baltimore, MD)
Date of First Priority Issue: Friday November 15th, 1996
Three-dimensional stromal tissue cultures
Patent Number: 5962325This patent teaches how to generate three dimensional cultures of stem cells through the use of special metrices and TGF beta. The three dimensional cultures can be generated using a variety of stem cells including mesenchymal stem cells. The mesenchymal stem cells may be extracted from bone marrow, cord blood or other sources.
Inventors: Naughton, Gail K. (La Jolla, CA); Naughton, Brian A. (El Cajon, CA)
Assignee: Advanced Tissue Sciences, Inc. (La Jolla, CA)
Date of First Priority Issue: Friday April 18th, 1986
Expansion of bone marrow stromal cells
Patent Number: 5962323This patent teaches how to grow bone marrow stromal cells in vitro. Several types of culture conditions for growing stromal cells are given. For example, the stromal cells may be expanded by treatment with FGF-1 on gelatin-coated plates. If FGF-1 can stimulate stromal cells in vitro, one wonders whether it also has similar in vivo abilities. The reason this is important is that there are...
Inventors: Greenberger, Joel S. (Sewickley, PA); Hurwitz, David R. (Acton, MA)
Assignee: ALG Company (Marlboro, MA)
Date of First Priority Issue: Friday December 29th, 1995
Leukemia inhibitory factor from mammalian species and use thereof to enhance implantation and development of embryos
Patent Number: 5962321This patent teaches the use of the cytokine LIF for increasing the rate of implantation of embryos. This patent is useful for generation of knockout and transgenic mice.
Inventors: Gough, Nicholas Martin (North Balwyn, AU); Willson, Tracey Ann (North Balwyn, AU); Seamark, Robert Frederick (Beulah Park, AU)
Assignee: Amrad Corporation Limited (Victoria, AU)
Date of First Priority Issue: Thursday December 1st, 1994
Engraftable human neural stem cells
Patent Number: 5958767This patent covers a type of neural stem cells that is isolated from human fetal telencephalon. This stem cell can be propagated in vitro and subsequently implanted for therapeutic benefit in a wide variety of animal models.
Inventors: Snyder, Evan Y. (Jamaica Plain, MA); Wolfe, John H. (Philadelphia, PA); Kim, Seung U. (Vancouver, CA)
Assignee: The Children's Medical Center Corp. (Boston, MA)
Date of First Priority Issue: Friday August 14th, 1998
In-vitro-derived human neutrophil precursor cells
Patent Number: 5955357This patent covers the differentiation of hematopoietic stem cells into neutrophil stem cells. The neutrophil stem cell is a type of cell that gives rise primarily to neutrophils upon further differentiation.
Inventors: Bender, James G. (Lindenhurst, IL); Maples, Phillip B. (Waukegan, IL); Smith, Stephen L. (Arlington Heights, IL); Unverzagt, Kristen L. (Palatine, IL); Van Epps, Dennis E. (Cary, IL)
Assignee: Nexell Therapeutics Inc. (Irvine, CA)
Date of First Priority Issue: Monday March 23rd, 1992