Patents
Engraftable human neural stem cells
Patent Number: 6541255These are stem cells that are isolated from human fetal telencephalon and are useful for engrafting and generating various neuronal structures.
Inventors: Snyder, Evan Y. (Jamaica Plain, MA); Wolfe, John H. (Philadelphia, PA); Kim, Seung U. (Vancouver, CA)
Assignee: The Children's Medical Center Corporation (Boston, MA); The University of British Columbia (CA); The University of Pennsylvania (Philadelphia, PA)
Date of First Priority Issue: Friday August 14th, 1998
Immortalized human stromal cell lines
Patent Number: 6541249This patent covers some stromal cell lines that have been deposited with ATCC. These cell lines are useful for expansion of hematopoietic stem cells since they secrete a variety of different cytokines. I would be interesting to see if they support expansion of other types of stem cells such as neuronal stem cells.
Inventors: Wager, Ruth E. (Rockville, MD); Ourmanova, Maria (Boyds, MD)
Assignee: Human Genome Sciences, Inc. (Rockville, MD)
Date of First Priority Issue: Wednesday December 22nd, 1999
Method of isolating ependymal neural stem cells
Patent Number: 6541247This patent covers stem cells of the ependymal CNS type from an animal that is non-embryonic. These neuronal stem cells can be isolated based on expression of Notch-1 receptor.
Inventors: Frisen, Jonas (Stockholm, SE); Janson, Ann Marie (Stockholm, SE); Johansson, Clas (Stockholm, SE); Momma, Stefan (Sp.ang.nga, SE); Clarke, Diana (Stockholm, SE); Zhao, Ming (Solna, SE); Lendahl, Urban (Sundbyberg, SE); Delfani, Kioumars (Solna, SE)
Assignee: Neuronova AB (Stockholm, SE)
Date of First Priority Issue: Monday May 25th, 1998
Hematopoietic stem cell growth factor (SCGF)
Patent Number: 6541217This patent covers a cytokine that is able to stimulate proliferation of hematopoietic stem cells. It is unclear what the modern name of this cytokine is. This patent may be very useful for development of a stem cell pharmaceutical.
Inventors: Hiraoka, Atsunobu (Kyoto-shi, Kyoto 616-8428, JP); Sugimura, Atsushi (Hokkaido, JP); Mio, Hiroyuki (Shizuoka, JP)
Assignee: Kyowa Hakko Kogyo Co., Ltd. (Tokyo, JP); Hiraoka, Atsunobu (Kyoto, JP)
Date of First Priority Issue: Tuesday August 27th, 1996
Regeneration and augmentation of bone using mesenchymal stem cells
Patent Number: 6541024This patent teaches ways of generating bone tissue using mesenchymal stem cells that are placed into a special matrix. In one embodiment, the matrix and the mesenchymal stem cells are administered into an area of bone injury.
Inventors: Kadiyala, Sudhakar (Baltimore, MD); Bruder, Scott P. (Owings Mills, MD)
Assignee: Osiris Therapeutics, Inc. (Baltimore, MD)
Date of First Priority Issue: Monday October 28th, 1996
Use of nerve growth factor for the storage, culture or treatment of cornea
Patent Number: 6537808This patent covers the use of NGF for storing corneal samples, but also for use as a topical solution for the treatment of diseases associated with corneal dysfunction.
Inventor: Lambiase, Alessandro (Rome, IT)
Assignee: Anabasis S.R.L. (Rome, IT)
Date of First Priority Issue: Thursday April 24th, 1997
Hematopoietic stem cells
Patent Number: 6537807This patent is in competition with other composition of matter patents that cover hematopoietic stem cells. Specific phenotypes are covered by this patent, which may be the reason why it issued in light of several other patents that also cover similar phenotypes and activities.
Inventors: Smith, Clayton A. (Durham, NC); Storms, Robert W. (Durham, NC); Gilboa, Eli (Durham, NC)
Assignee: Duke university
Date of First Priority Issue: Thursday December 4th, 1997
Porous tissue scaffoldings for the repair or regeneration of tissue
Patent Number: 6534084The importance of scaffolds in tissue engineering can not be understated. In this patent, various composition of matter, included foam-based and biodegradable scaffolds are provided.
Inventors: Vyakarnam, Murty N. (Edison, NJ); Zimmerman, Mark C. (East Brunswick, NJ); Scopelianos, Angelo George (Whitehouse Station, NJ); Roller, Mark B. (North Brunswick, NJ); Gorky, David V. (Flemington, NJ)
Assignee: Ethicon, Inc. (Somerville, NJ)
Date of First Priority Issue: Wednesday June 30th, 1999
Cardiac function comprising implantation of embryonic stem cell in which differentiation has been initiated
Patent Number: 6534052This patent teaches how to administer embryonic stem cells, and differentiated cells thereof, into the area of infarcted myocardium so as to prevent future heart failure.
Inventors: Xiao, Yong-Fu (Wayland, MA); Morgan, James P. (Newton Centre, MA)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Tuesday September 5th, 2000
Protein-induced morphogenesis in liver tissue
Patent Number: 6531445This patent teaches the use of proteins such as osteogenic protein-1 (OP-1) for stimulation of liver regeneration.
Inventors: Cohen, Charles M. (Medway, MA); Kuberasampath, Thangavel (Medway, MA); Pang, Roy H. L. (Medway, MA); Oppermann, Hermann (Medway, MA); Rueger, David C. (Hopkinton, MA)
Assignee: Curis, Inc. (Cambridge, MA)
Date of First Priority Issue: Monday March 11th, 1991