Patents
Resorbable scaffolds to promote cartilage regeneration
Patent Number: 6530956This patent teaches how to make scaffolds that can be implanted in order to promote healing and regeneration of injured cartilage. Chondrocytes and/or mesenchymal stem cells may be used along with this invention.
Inventor: Mansmann, Kevin A. (Paoli, PA
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Thursday September 10th, 1998
Engraftable human neural stem cells
Patent Number: 6528306This patent uses human fetal telencephalon as a source of stem cells that can be implanted and subsequent to implantation actually interdigitate and function in unison with host neurons.
Inventors: Snyder, Evan Y. (Jamaica Plain, MA); Wolfe, John H. (Philadelphia, PA); Kim, Seung U. (Vancouver, CA)
Assignee: The Children's of Medical Center Corporation (Boston, MA); The University of British Columbia (CA); The University of Pennsylvania (Philadelphia, PA)
Date of First Priority Issue: Tuesday April 14th, 1998
Bone marrow cells as a source of neurons for brain and spinal cord repair
Patent Number: 6528245This patent teaches that bone marrow stromal cells may be used as a source of neurons or to assist in neuronal regeneration. One wonders if these bone marrow stromal cells are similar to the mesenchymal stem cells that are patented by Osiris Therapeutics.
Inventors: Sanchez-Ramos, Juan (Tampa, FL); Song, Shijie (Tampa, FL); Janssen, William (Tampa, FL); Sanberg, Paul (Spring Hill, FL); Freeman, Thomas (Tampa, FL)
Assignee: University of South Florida (Tampa, FL)
Date of First Priority Issue: Thursday May 7th, 1998
Method for in vivo ex vivo and in vitro repair and regeneration of cartilage and collagen and bone remodeling
Patent Number: 6528052This patent discloses frequencies and methods of culturing stem cells in order to generate a source of bioartificial cartilage.
Inventors: Smith, R. Lane (Palo Alto, CA); Carter, Dennis R. (Stanford, CA); Schurman, David J. (Stanford, CA)
Assignee: The Board of Trustees of the Leland Stanford Junior University (Stanford, CA)
Date of First Priority Issue: Friday October 1st, 1999
Unactivated oocytes as cytoplast recipients of quiescent cell nuclei while maintaining correct ploidy
Patent Number: 6525243This patent teaches ways of improving efficacy of cloning through nuclear transfer into oocytes that are in specific stages of proliferation. The use of cloning for generation of autologous embryonic stem cells offers incredible potential for regenerative medicine.
Inventors: Stockman Campbell, Keith Henry (Midlothian, GB); Wilmut, Ian (Midlothian, GB) Assignee: Roslin Institute (Edinburgh, GB)
Assignee: The Minister of Agricultural, Fisheries and Food (GB); Biotechnology & Biological Sciences Research Council (GB)
Date of First Priority Issue: Thursday August 31st, 1995
Gene delivery to periosteal cells by microneedle injection
Patent Number: 6525030The periosteum is a dense layer of connective tissue that wraps around bone. This patent teaches ways of transfecting this layer with various genes that are capable of stimulating stem cells and other cells to proliferate and/or differentiate.
Inventor: Eriksson, Elof (Wellesley Hills, MA)
Assignee: Applied Tissue Technologies, LLC (Wellesley Hills, MA)
Date of First Priority Issue: Thursday December 14th, 1989
FGFR3 as a marker for mesenchymal skeletal progenitor cells
Patent Number: 6517872This patent teaches ways of extracting mesenchymal stem cells that act as progenitors for various types of bone. The expression of the receptor for fibroblast growth factor-3 is used as the identifying marker.
Inventors: Yayon, Avner (Moshav Sitria, IL); Nevo, Zvi (Herzlia, IL)
Assignee: Yeda Research and Development Co., Ltd. (Rehovot, IL); Ramdt University Authority for Applied Research and Industrial Development Ltd. (Tel Aviv, IL)
Date of First Priority Issue: Thursday January 12th, 1995
Neural retinal cells and retinal pigment epithelium cells and their use in treatment of retinal disorders
Patent Number: 6517833This patent teaches the use of pig retinal cells and a variety of stem cells associated with retinal development, as a source of cellular material for transplantation into humans that suffer from various ocular diseases.
Inventor: Edge, Albert (Cambridge, MA)
Assignee: Diacrin, Inc. (Charlestown, MA)
Date of First Priority Issue: Tuesday August 25th, 1998
Homologous recombination for universal donor cells and chimeric mammalian hosts
Patent Number: 6514752This patent discloses a stem cell theat has been modified so as to lack expression of MHC genes. The modification involves homologous recombination in a manner similar to which knockout mice are made. The cells are then used for transplantation since they are presumed to be less immunogeneic. If it was possible to generate liver cells through this method, then the therapy may actually be...
Inventors: Kucherlapati, Raju (Darien, CT); Koller, Beverly H. (Carrboro, NC); Smithies, Oliver (Chapel Hill, NC); Dubridge, Robert B. (Belmont, CA); Greenburg, Gary (San Carlos, CA); Capon, Daniel J. (Hillsborough, CA); Williams, Steven R. (San Francisco, CA); Arbo
Assignee: cell genesys
Date of First Priority Issue: Tuesday July 25th, 1989
Polymer constructs
Patent Number: 6514522This patent provides compositions of matter for administration of cells and cytokines into a host. The compositions are various polymers that are biodegradable, but can serve as delivery systems.
Inventor: Domb, Abraham J. (Efrat, IL)
Assignee: Chondros, Inc. (Towson, MD)
Date of First Priority Issue: Wednesday April 8th, 1998