Patents
Device and method for regeneration and repair of cartilage lesions
Patent Number: 6514514This patent covers a matrix that can be used for cartilage repair comprising of biodegradable materials, as well as cytokines and growth factors.
Inventors: Atkinson, Brent (Lakewood, CO); Benedict, James J. (Arvada, CO)
Assignee: Sulzer Biologics Inc. (Austin, TX)
Date of First Priority Issue: Thursday August 14th, 1997
Methods of treating anosmia and repopulating olfactory nerves with retinoids
Patent Number: 6506801This patent teaches the use of retinoids to stimulate olfactory stem cells in order to restore the sense of smell to an animal in need thereof. The use of retinoids for stimulation of stem cell differentiation is well known and is actually therapeutic in various types of cancer, in which the malignant cell is subjected to "differentiation therapy" such that it loses its malignancy.
Inventors: Yee, Karen K. (Philadelphia, PA); Rawson, Nancy E. (Marlton, NJ)
Assignee: Monell Chemical Senses Center (Philadelphia, PA)
Date of First Priority Issue: Wednesday October 4th, 2000
Method for culturing langerhans islets and islet autotransplantation islet regeneration
Patent Number: 6506599This patent teaches how to expand autologous or allogeneic islet stem cells and to generate from them islets useful for the treatment of diabetes. The culture techniques disclosed involve cytokine, matrix and antibody cocktails. This invention may be useful in conjunction with the various embryonic stem cell technologies that are currently being studied.
Inventor: Yoon, Tai-Wook (Seodaemoon-Ku Seoul, KR)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Friday October 15th, 1999
Serum-and steroid-free culture media for cerebellar granule neurons
Patent Number: 6506576This patent covers a method of growing neurons in a media that is free from serum and feeder cells. This media will be important in clinical trials since there are high regulatory hurdles if cells are used that are grown in the presence of xenogenic feeders or with serum containing media.
Inventor: Belcher, Scott M. (Little Rock, AR)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Wednesday March 14th, 2001
Hepatocyte lineage cells derived from pluripotent stem cells
Patent Number: 6506574This patent teaches how to generate hepatocytes by the differentiation of embryonic stem cells. Methods of using the newly generated hepatocytes for drug screening are also provided. The patent describes uses of histone decetylase inhibitors in the culture and differentiation process.
Inventors: Rambhatla, Lakshmi (Redwood City, CA); Carpenter, Melissa K. (Castro Valley, CA)
Assignee: Geron Corporation (Menlo Park, CA)
Date of First Priority Issue: Thursday April 27th, 2000
In vivo selection of primitive hematopoietic cells
Patent Number: 6500421This patent teaches ways of using tranfection of hematopoietic stem cells in order to select for primitive cells in vivo. This patent is useful for treatment of a variety of hematological disorders in which stem cell transplants are indicated.
Inventors: Sorrentino, Brian P. (Memphis, TN); Blakely, Raymond L. (Germantown, TN); Allay, James (Cordova, TN); Spencer, H. Trent (Columbia, SC)
Assignee: St. Jude Children's Research Hospital (Nashville, TN)
Date of First Priority Issue: Monday November 4th, 1996
Low molecular weight cell, bone marrow and immune stimulants
Patent Number: 6498150This patent covers the composition of matter for several aminocarboxylic acid amide derivatives that are both immunostimulatory, as well as augment hematopoietic activity of stem cells. This seems very interesting a combination since many cytokines that stimulate the immune system, at least the Th1 arm of the immune system, are also suppressive to the hematopoietic compartment. For...
Inventors: Taub, Floyd (Silver Spring, MD); Perun, Thomas J. (Round Lake, IL); Murray, Christopher K. (Longmont, CO); Daughenbaugh, Randall J. (Longmont, CO); Lednicer, Daniel (Rockville, MD)
Assignee: Dovetail Technologies, Inc. (College Park, MD)
Date of First Priority Issue: Tuesday October 17th, 1995
Method of promoting production of living tissue equivalents
Patent Number: 6498138This patent covers the use of angiotensinogen I and II and fragments thereof for promoting viability of tissues. This could be used form maintaining the viability of stem cells during organ storage.
Inventors: Rodgers, Kathleen E. (Long Beach, CA); DiZerega, Gere (Pasadena, CA)
Assignee: University of Southern California (Los Angeles, CA)
Date of First Priority Issue: Wednesday March 11th, 1998
Cultures of human CNS neural stem cells
Patent Number: 6498018This patent appears to cover a method of screening for compounds that have ability to induce expension of neuronal stem cells. In one of the dependent claims the patent covers forebrain derived neural stem cells in the culture for screening.
Inventor: Carpenter, Melissa (Foster City, CA)
Assignee: Cytotherapeutics, Inc. (Lincoln, RI)
Date of First Priority Issue: Friday September 5th, 1997
Multilayer skin or dermal equivalent having a layer containing mesenchymal stem cells
Patent Number: 6497875This patent covers the generation of an artificial skin that has a keratinocyte layer and a dermis-forming layer. The second layer can be generated by use of mesenchymal stem cells. This patent could be useful not only for covering of burn patients or sufferers of wounds that take a long time to heal, but it could also be useful for generation of in vitro systems for assessing ability of topical...
Inventors: Sorrell, J. Michael (Cleveland Heights, OH); Caplan, Arnold I. (Cleveland Heights, OH)
Assignee: Case Western Reserve University (Cleveland, OH)
Date of First Priority Issue: Friday April 26th, 1996