Patents
Neural transplantation using proliferated multipotent neural stem cells and their progeny
Patent Number: 6497872This patent covers the use of a multipotent neural stem cell for transplantation into patients suffering from various neurodegenerative disorders. Markers of the cells suitable for transplantation, as well as culture conditions, and genes which the stem cells can be transfected with are provided.
Inventors: Weiss, Samuel (Alberta, CA); Reynolds, Brent (Alberta, CA); Hammang, Joseph P. (Barrington, RI); Baetge, E. Edward (Barrington, RI)
Assignee: NeuroSpheres Holdings Ltd. (Calgary, CA)
Date of First Priority Issue: Monday July 8th, 1991
Morphogen-enhanced survival and repair of neural cells
Patent Number: 6495513This patent provides certain morphogen proteins that are capable of regenerating neural stem cells, as well as protecting neurons from apoptosis or other types of cell death. The claims cover specific polypeptides for neurite extension, as well as for repairing the gap between neurons.
Inventors: Rueger, David C. (Hopkinton, MA); Kuberasampath, Thangavel (Medway, MA); Oppermann, Hermann (Medway, MA); Ozkaynak, Engin (Milford, MA); Pang, Roy H. L. (Etna, NH); Cohen, Charles M. (Medway, MA)
Assignee: Curis, Inc. (Cambridge, MA)
Date of First Priority Issue: Monday March 11th, 1991
Hematopoietic stem cell proliferating agents
Patent Number: 6495365This patent covers the use of IGF-1 (a protein that is already in the clinic) in combination with a protein selected from the group comprising of: G-CSF, M-CSF, or stem cell factor, for the stimulation of hematopoiesis. This patent should be examined for the possibility of extending this technology to the area of other uses of hematopoietic stem cells. For example, will these combinations...
Inventors: Saito, Yoshimasa (Kawanishi, JP); Ueda, Yoshiko (Osaka, JP); Tamura, Kouichi (Kobe, JP); Takata, Yoko (Osaka, JP); Yamada, Hisashi (Sanda, JP); Yamashita, Tatsuo (Kobe, JP); Kobayashi, Masakazu (Takarazuka, JP)
Assignee: Fujisawa Pharmaceutical Co., Ltd. (Osaka, JP)
Date of First Priority Issue: Tuesday August 12th, 1997
Keratinocyte stem cells
Patent Number: 6485971This patent covers a type of stem cell that gives rise to keratinocytes. These cells can be purified from skin biopsy and used for amplification and generation of numerous other cell types and tissue. One interesting possibility is the use of such keratinocyte stem cells for generation of artificial thymus.
Inventors: Kaur, Pritinder (East Melbourne, AU); Simmons, Paul J. (East Melbourne, AU)
Assignee: Peter MacCallum Cancer Institute (Victoria, AU)
Date of First Priority Issue: Wednesday March 18th, 1998
Treatment methods using homeopathic preparations of growth factors
Patent Number: 6485480The process of ultradiluting a compound in order to magically "potentiate" various effects has been used for hundreds of years in the area of homeopathic medicine. Homeopathy is based on the principle of "like cures like", in the sense that if you are allergic to a specific compound, the ultradilution of that compound, prepared through a magical shaking during the dilution process, will result in...
Inventor: Brewitt, Barbara A. (Seattle, WA)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Thursday March 31st, 1994
Methods and compositions for producing artificial fascia
Patent Number: 6482645The fascia is a layer of connective tissue that surrounds muscles, bones, and joints. This patent teaches ways of generating artificial fascia's through the use of various stem cells and biological matrices.
Inventor: Atala, Anthony (Weston, MA)
Assignee: Children's Medical Center Corporation (Boston, MA)
Date of First Priority Issue: Wednesday December 29th, 1999
Cell-based gene therapy for the pulmonary system
Patent Number: 6482406This patent covers the transfection of various cells and their administration in order to heal various pulmonary lesions or disorders. In one utilization, cells are transfected with iNOS and used to administer nitric oxide directly into the lung of patients with pulmonary hypertension.
Inventor: Stewart, Duncan J. (Toronto, Ontario, CA)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Friday March 26th, 1999
Stimulation, culture and preservation of pancreatic cells
Patent Number: 6479283This patent covers a method of administering beta cells in a matrix that allows for enhanced viability, as well as insulin production.
Inventors: M.ang.nsson, Per (Sollentuna, SE); Lundin, Tomas (Enkoping, SE); Busch, Christer (Troms.o slashed., SE)
Assignee: Ascendia AB (Sollentuna, SE)
Date of First Priority Issue: Tuesday March 18th, 1997
Device having a microporous membrane lined deformable wall for implanting cell cultures
Patent Number: 6479066This patent covers an implantable 3 dimensional matrix that takes the shape of the cavity it is administered in. This matrix is a great delivery system for introduction of various cell types into the host. In some ways this patent is useful for generation of compositions useful for the treatment of bone defects, livers, and other bodily structures.
Inventor: Harpstead, Stanley D. (Arden Hills, MN)
Assignee: RST Implanted Cell Technology, LLC (Arden Hills, MN)
Date of First Priority Issue: Thursday December 16th, 1999
Purging of stem cell products
Patent Number: 6475481This patent covers ways of purging tumor cells from bone marrow stem cell grafts. Specifically, the patent teachs ways of selectively protecting the bone marrow through gene transfection, while allowing tumor cells to die. This patent is particularly suited for situations of autolous bone marrow transplants in cancer patients in order to allow for high levels of chemotherapy and/or...
Inventor: Talmadge, James E. (Bellevue, NE)
Assignee: Canji, Inc. (San Diego, CA)
Date of First Priority Issue: Tuesday November 18th, 1997