Patents
Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
Patent Number: 6468794StemCells Inc is one of the few companies that has actually entered clinical trials. In this patent the extraction of specific neuronal stem cells is disclosed. Cells that bind to the antibodies 5E12 and/or AC133 derived from brain sources are identified as neuronal stem cells capable of inducing production of neurospheres. These cells have also demonstrated ability to integrate into the brains...
Inventors: Uchida, Nobuko (Palo Alto, CA); Buck, David W. (Santa Clara, CA); Weissman, Irving (Redwood City, CA)
Assignee: StemCells, Inc. (Palo Alto, CA)
Date of First Priority Issue: Friday February 12th, 1999
Use of .beta.-catenin in the expansion of stem and progenitor cells
Patent Number: 6465249The various signalling pathways associated with embryogenesis seem to be fundamentally important in controlling a variety of stem cells. In this patent the manipulation of beta catenin signalling is covered for the activation of stem cells to either differentiate or proliferate.
Inventors: Reya, Tannishtha (Mountain View, CA); Nusse, Roeland (Stanford, CA); Weissman, Irving L. (Redwood City, CA)
Assignee: The Board of Trustees of the Leland Stanford Junior University (Palo Alto, CA)
Date of First Priority Issue: Tuesday January 18th, 2000
Methods for producing and preparing cells for cell therapy
Patent Number: 6465248This patent teaches ways how to culture neurons in order to obtain certain phenotypes. One type of neuron that is obtained by using the culture conditions thought by this invention is a dopamine secreting neuron. This invention is owned by the company Prescient NeuroPharma which appears to be a Canadian venture-backed company.
Inventor: Commissiong, John (Mississauga, CA)
Assignee: Prescient NeuroPharma, Inc. (Toronto, CA)
Date of First Priority Issue: Friday July 16th, 1999
Mammalian myeloid progenitor cell subsets
Patent Number: 6465247This patent covers a type of stem cell that has differentiated and is committed to the myeloid lineage. This stem cell is useful for inducing a rapid production of myeloid cells such as granulocytes and monocytes, which are protective against bacteria. The cells covered in the patent display the phenotype of c-kit positive, negative for IL-7 receptor (most likely since IL-7 is associated...
Inventors: Weissman, Irving L. (Redwood City, CA); Traver, David Jeffrey (West Roxbury, MA); Akashi, Koichi (Palo Alto, CA)
Assignee: The Board of Trustees of the Leland Stanford Junior University (Palo Alto, CA)
Date of First Priority Issue: Tuesday June 29th, 1999
Identification of cells for transplantation
Patent Number: 6465215This patent covers genes that are indicative if cells of the neuronal lineage are suitable for transplantation for regenerative purposes. The genes mentioned in this patent are not named, but sequences are provided. So if one is curious what these are, they have to check genbank.
Inventors: Price, Jack (London, GB); Uwanogho, Dafe (London, GB)
Assignee: Reneuron Limited (London, GB)
Date of First Priority Issue: Tuesday December 14th, 1999
Methods and uses of connective tissue growth factor for differentiation of mesenchymal stem cells
Patent Number: 6464983This patent teaches how to induce mesenchymal stem cells into chondrocytes (to make cartilage) or osteoblasts (to make bone) through the use of the cytokine called Connective Tissue Growth Factor. This patent is useful for regenerative purposes in the area of injuries, however it is interesting in that the mesenchymal stem cell patents are owned by Osiris and should be licensed in order to...
Inventor: Grotendorst, Gary R. (Miami, FL)
Assignee: University of South Florida (Tampa, FL); University of Miami (Miami, FL)
Date of First Priority Issue: Tuesday April 30th, 1991
Bone marrow as a site for transplantation
Patent Number: 6463933This patent teaches how to perform transplantation of cells directly into the bone or bone marrow. The patent specifically claims the transplantation of hepatocytes or islet cells. It is known that the bone marrow is an immune priviledged environment, at least to some extent, therefore this idea is really novel. Sakaguchi in Japan was at one time publishing that intra-bone transplant of...
Inventors: Laster, Morris (Jerusalem, 97289, IL); Rosenwald, Lindsay (New York, NY)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Tuesday March 25th, 1997
Hepatocyte lineage cells derived from pluripotent stem cells
Patent Number: 6458589This patent covers methods of generating and isolating hepatocytes from embryonic stem cells. The hepatocytes are designated by specific phenotypic and functional characteristics that are described in the patent. This invention could be useful for treatment of a wide variety of disorders ranging from hepatitis to cirrhosis.
Inventors: Rambhatla, Lakshmi (Redwood City, CA); Carpenter, Melissa K. (Castro Valley, CA)
Assignee: geron
Date of First Priority Issue: Thursday April 27th, 2000
Renal stem cells and uses thereof
Patent Number: 6458588This patent covers a renal stem cell that is identified based on expression of the markers flk-1 and Sca-1. It is interesting how some many stem cells of different tissues all express similar markers and in some situations similar properties. Examples of such similarities include expression of Sca-1 (which appropriately stands for "stem cell antigen") on stem cells ranging from...
Inventors: Arnaout, M. Amin (Chestnut Hill, MA); Linde, Peter G. (Dedham, MA)
Assignee: The General Hospital Corporation (Boston, MA)
Date of First Priority Issue: Wednesday January 31st, 2001
Human hematopoietic stem and progenitor cell antigen
Patent Number: 6455678This patent appears to cover the stem cell antigen AC133, otherwise known as CD133. This antigen is found not only on hematopoietic stem cells, but also on stem cells capable of inducing angiogenesis. This patent may be useful for people who do not want to licence CD34.
Inventors: Yin, Amy H. (San Jose, CA); Miraglia, Sheri (Palo Alto, CA); Godfry, Wayne G. (Atherton, CA); Buck, David W. (Santa Clara, CA)
Assignee: AmCell Corporation (Burlingame, CA)
Date of First Priority Issue: Friday April 26th, 1996