Patents
Patent Number: 6451558
This patent covers some genes whose function is not really described in the application. In order to understant the relevance of this patent, one should take the sequence and blast it in genbank to see what the real name of this gene is.
Inventors: Cooke, Michael Paul (Del Mar, CA); Holness, Claire Louise (Palo Alto, CA); Sirenko, Oksana Ivanivna (Belmont, CA)
Assignee: Novartis AG (Basel, CH)
Date of First Priority Issue: Monday August 3rd, 1998
Patent Number: 6454811
This patent provides various engineering techniques and devices for generation of artificial tissue from biological sources in vitro and in vivo.
Specific material and ways of manipulating the materials to design cellular substrates and shape inducing structures are disclosed.
Inventors: Sherwood, Jill K. (Princeton, NJ); Griffith, Linda G. (Cambridge, MA); Brown, Scott (Princeton, NJ)
Assignee: Massachusetts Institute of Technology (Cambridge, MA); Therics, Inc. (Princeton, NJ)
Date of First Priority Issue: Monday October 12th, 1998
Patent Number: 6451306
This patent covers a method of treating a neurodegenerative condition through administration of neuronal stem cells into the cholinergic basal forebrain that have been transfected with nerve growth factor or a neurotropin.
This patent uses the natural ability of neural stem cells to migrate to the place where they are needed, in order to deliver the protein that is produced from the gene that...
Inventors: Tuszynski, Mark H. (La Jolla, CA); Gage, Fred (La Jolla, CA)
Assignee: The Regents of the University of California (Oakland, CA)
Date of First Priority Issue: Wednesday April 15th, 1998
Patent Number: 6451303
There are more than 20 members of the fibroblast growth factor family. Many of the FGF proteins are involved in activation of stem cell proliferation, as well as induction of angiogenesis. This patent covers the treatment of coronary artery disease, for example ischemia induced by it...through the stimulation of angiogenesis by administration of FGF.
There is at least one trial ongoing with...
Inventors: Whitehouse, Martha J. (San Francisco, CA); Kavanaugh, W. Michael (Marin, CA)
Assignee: Chiron Corporation (Emeryville, CA)
Date of First Priority Issue: Tuesday October 13th, 1998
Patent Number: 6447766
Inventors: Pelus, Louis Martin (Richboro, PA); King, Andrew Garrison (Blue Bell, PA); Qian, Yanqiu (King of Prussia, PA)
Assignee: SmithKline Beecham Corporation (Philadelphia, PA)
Date of First Priority Issue: Tuesday June 8th, 1993
Patent Number: 6444205
This patent covers administration of GABA producing neurons or neural stem cells from a fetus into a patient with chronic pain or spasticity. This patent covers not only human donor sources but also porcine.
The ability to generate different types of pigs through genetic engineering may allow for some of these approaches to enter the clinic. One such particular strain of pig is the alpha...
Inventors: Dinsmore, Jonathan (Brookline, MA); Siegan, Julie (Boston, MA)
Assignee: Diacrin, Inc. (Charlestown, MA)
Date of First Priority Issue: Wednesday September 30th, 1998
Patent Number: 6440934
This patent covers specific doses of FGF-2 that may be used for the stimulation of angiogenesis.
Angiogenesis stimulation should not be thought of as important only for disease such as angina, but for other disease associated with ischemia such as cerebral palsy, and peripheral vascular disease.
Inventor: Whitehouse, Martha Jo (San Francisco, CA)
Assignee: Chiron Corporation (Emeryville, CA)
Date of First Priority Issue: Tuesday October 13th, 1998
Patent Number: 6440734
This patent discloses various three dimensional biomaterials that resemble the actual bone marrow microenvironment and are useful for stimulating expansion of hematopoietic stem cells.
This patent may be used for expanding autologous stem cells for patients that lack a suitable bone marrow or stem cell donor.
Additionally, the ability to expand and grow hematopoietic stem cells can also...
Inventors: Pykett, Mark J. (Newton, MA); Rosenzweig, Michael (Boston, MA); Kaplan, Richard B. (Beverly Hills, CA)
Assignee: Cytomatrix, LLC (Woburn, MA)
Date of First Priority Issue: Friday September 25th, 1998
Patent Number: 6440407
This patent covers IL-3 and various forms of it for the expansion of hematopoietic stem cells outside of the body.
Inventors: Bauer, S. Christopher (New Haven, MO); Abrams, Mark Allen (St. Louis, MO); Braford-Goldberg, Sarah Ruth (St. Louis, MO); Caparon, Maire Helena (Chesterfield, MO); Easton, Alan Michael (Maryland Heights, MO); Klein, Barbara Kure (St. Louis, MO); McKearn, J
Assignee: Searle, G. D. (Chicago, IL)
Date of First Priority Issue: Tuesday November 24th, 1992
Patent Number: 6436704
This patent covers a type of pancreatic stem cell that can be grown and expanded outside of the body. The cells are defined as expressing the following markers: cytokeratin-19, CEA, carbonic anhydrase II, and CFTCR.
Inventors: Roberts, Penelope E. (Millbrae, CA); Mather, Jennie Powell (Millbrae, CA)
Assignee: Raven Biotechnologies, Inc. (South San Francisco, CA)
Date of First Priority Issue: Monday April 10th, 2000