News Posts
FGF-2 reduces SDF-1
Bethesda, MD - Numerous types of leukemias are associated with secretion of the cytokine fibroblast growth factor-2 (FGF-2). These leukemias are also associated with splenomegaly, hepatomegaly, and extramedullary hematopoiesis. In a recent paper (Nakayama et al. Effect of fibroblast growth factor 2 on stromal cell-derived factor 1 production by bone marrow stromal cells and...
MSC as Veto Cells II
Baltimore, MD - It is known that mesenchymal stem cells have veto-like properties. Essentially the veto cell inactivates, either through killing or induction of anergy, a cell that reacts against it. Theoretically, if the mesenchymal stem cells have veto-like properties, then this veto activity should be recognized in vivo by...
MSC = Veto cells
Duarte, CA - It is known that mesenchymal stem cells are potent immune modulators. The methods by which they inhibit various inflammatory reactions include production of immune suppressive cytokines such as IL-10, induction of tryptophan depletion using the enzyme IDO, and providing signal 1 in absense...
Stem Cell T Stimulation
Bethesda, Maryland - The return of ex vivo expanded T cells into an "empty compartment" has been used successfully by Steven Rosenberg and various researchers at the NIH for treatment of cancer. Essentially the idea is that when T cells are placed into a compartment that is lymphodepleted, then the T cells will proliferate by homeostatic expansion and be able to...
Limb Ischemia: Follow the leader
Nagoya, Japan - Readers of StemCellPatents.com will be familiar with a previous publication stating that cord blood derived stem cells can accelerate reconstitution of hematopoietic stem cells. This concept of one type of stem cell helping other types of stem cells was demonstrated in a recent paper by Kajiguchi et al (Safety and...
Liver regeneration by inhibiting the inhibitor
Kayseri, Turkey - Readers of StemCellPatents.com will be familiar with patents describing the inhibition of TGF-beta as a means of stimulating stem cell proliferation. Essentially, it is known in the hematopoietic system at least, that autocrine production of TGF-beta by stem...
Not all mitogens are the same
Cambridge, UK - Neurons communicate with each other by exchanging electrical signals through axons, or otherwise called nerve fibers. These axons are insulated by the phospholipid myelin, which acts as an insulator. Myelin is deposited on neurons of the peripheral nervous system by Schwann cells, and on neurons of the central nervous system by oligodendrocytes. Both Schwann cells and...
1 Comment
Adult stem cells: Fat to brain
Tokyo, Japan - [Watch the Video] The ability to adipose derived stem cells to differentiate into a variety of tissues is well known. Primarily, adipose derived stem cells are mesenchymal-like, however, they are also known to differentiate into endothelial cells. Some authors have published that not only can adipose derived stem...
Fat to endothelium
Aachen, Germany - The use of adipose tissue for regenerative medicine is particularly exciting since large amounts of autologous stem cells can be procured in this manner with minor discomfort to the patient. A recent publication (Wosnitza et al. Plasticity of human adipose stem cells to perform adipogenic and endothelial differentiation. Differentiation. 2007 Jan;75(1):12-23...
N-formyl peptides and Mesenchymal Stem Cells
New Orleans, Louisiana – One of the common themes in the study of stem cells is their ability to home into areas of damaged tissue. It is known that factors generated during hypoxia, such as stromal derived factor-1 generally attract stem cells, however other signals generated during injury that attract stem cells are less well understood. N-formyl peptides are cleavage products of...