News Posts
Lipid Attraction of Stem Cells
Montreal, Canada -
Stromal Derived Factor (SDF)-1 is one of the cell-to-cell communication signals that is involved in stem cells (mesenchymal and hematopoietic) migration to sites of injury. In a recent paper, (Meriane et al. Cooperation of matrix metalloproteinases with the RhoA/Rho kinase and mitogen-activated protein kinase kinase-1/extracellular signal-regulated kinase signaling... San Francisco, CA -
Lee et al published (Antibody Targeting of Stem Cells to Infarcted Myocardium. Stem Cells. 2006 Nov 30; [Epub ahead of print]) a novel technique of increasing the concentration of stem cells to specific injured tissue.
The investigators generated an antibody-like molecule of which one end binds to stem cells (well the actual antibody, anti-CD45) binds to many... Louisville, KY –
Stem cells from adult sources (non-embryonic) are generally believed to be restricted in differentiation potential. However, there are several reports of stem cells from bone marrow and cord blood that express makers of pluripotency. For example, in 2004 Prockop’s group from Tulane reported that if one incubates early passaged human bone marrow derived mesenchymal... Bethesda MD -
Readers of StemCellPatents.com are familiar with the patent of Loren Field which teaches that tissue-specific promoters can drive expression of markers from embryonic stem cell cultures so as to be able to selectively "fish out" stem cells that are starting to commit to a specific lineage.
In a recent paper (Heo... The issue of what improvements to existing technologies are "non-obvious" and therefore deserve awarding of patents is critical for those of us involved in biotechnology.
Oral arguments for the first Supreme Court Case in more than 30 years examining this issue, KSR v Teleflex, were heard... Rehovot, Israel –
It is known that exosomes, small, viral-sized particles are used by the immune system to communicate with itself.
In a recent paper published by Lapidot’s group (Kalinkovich et al. Functional CXCR4-expressing microparticles and SDF-1 correlate with circulating acute myelogenous leukemia cells. Cancer Res. 2006 Nov... Loma Linda CA-
We at StemCellPatents.com have described in various patents the relationship between hematopoietic stem cells and neural stem cells. Stunning examples include the ability of neurons to stimulate hematopoiesis, Patent # 6897060, the ability of the same hypoxic conditions that promote hematopoietic stem cell... Iowa City, Iowa USA
Due to the great interest generated by the first clinical use of embryonic stem cells we decided to see other papers in the area of immunological activities of embryonic stem cells.
The possibility that embryonic stem cells can be immune suppressive and therefore transplanted across... London, UK
Guillot et al published in the Nov 22 edition of Stem Cells a paper entitled "Human first trimester fetal mesenchymal stem cells (MSC) express pluripotency markers, grow faster, and have longer telomeres compared to adult MSC." which suggests several advantages to regenerative uses of fetal derived mesenchymal stem cells as compared to the currently... Gujarat, India -
To our knowledge the first-ever peer-reviewed publication describing clinical use of embryonic stem cells has appeared this week in the journal Transplantation Proceedings (Trivedi et al. Embryonic stem cell derived and adult hematopoietic stem cell transplantation for tolerance induction in a renal allograft recipient:-a case report.Transplant Proc... 
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Sticking it to Infarcted Myocardium
Stem Cells Come in All Shapes and Sizes
ES cells to Hepatocytes
Oral Arguments for Obviousness
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Exosomes and Stem Cells...
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G-CSF of Blood and Brain
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Tolerogeneicity of Embryonic Stem Cells in Allogeneic animals
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Mesenchymal Stem Cells: The younger the better !
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First Clinical Use of ES Cells
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