News Posts
First Clinical Use of ES Cells
Gujarat, India - To our knowledge the first-ever peer-reviewed publication describing clinical use of embryonic stem cells has appeared this week in the journal Transplantation Proceedings (Trivedi et al. Embryonic stem cell derived and adult hematopoietic stem cell transplantation for tolerance induction in a renal allograft recipient:-a case report.Transplant Proc. 2006...Sunday November 26th, 2006 @ 18:10:34 EST
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Inflammation TWEAKs Stem Cell Expansion
Watertown, MA Girgenrath M et al published in today's online version of EMBO a paper entitled TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration which demonstrates the ability of inflammatory stimuli to induce mesenchymal stem cell proliferation. The authors reported that the cytokine known as TNF-like weak inducer of...Sunday November 26th, 2006 @ 17:00:46 EST
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Colon Cancer Stem Cell Revealed
Toronto Canada - Researchers at Princess Margaret Hospital in Toronto published in todays journal Nature the identification of a cell population within the bulk tumour mass that possesses the functional characteristics of a tumor stem cell. In a paper entitled "A human colon cancer cell capable of initiating tumour growth in immunodeficient mice." John Dick's group essentially demonstrated...Friday November 24th, 2006 @ 11:49:24 EST
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Nose to Hair: Differentiation of Olfactory Stem Cells
Sydney Australia - In a study published in today's issue of Stem Cells, Australian scientists reported a unique methodology for coaxing olfactory adult stem cells to acquire the phenotype of cochlear hair cells. This finding is important because deafness results from loss of cochlear hair cells and the ability to generate these cells in vitro would conceptually open the door for cell therapy...Wednesday November 22nd, 2006 @ 21:18:19 EST
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Lipid Stimulation of Mesenchymal Differentiation
Seoul South Korea - Jeon et al published today in the online version of the Journal of Cell Sciences that exposure of mesenchymal stem cells to the lipid sphingosylphosphorylcholine (SPC) induces differentiation into smooth muscle cells in a paper entitled "Sphingosylphosphorylcholine induces differentiation of human mesenchymal stem cells into smooth-muscle-like cells through a...Thursday November 16th, 2006 @ 22:40:39 EST
Electrical signals inducing stem cell differentation
Saitama Japan- In today's issue of the journal Stem Cells, Yamada et al reported that electrical stimulation of embryonic stem cells resulted in induction of differentiation into the neural lineage. In a paper entitled "Electrical stimulation modulates fate determination of differentiating embryonic stem cells", the authors demonstrated that embryonic stem cells differentiated by electrical...Thursday November 16th, 2006 @ 17:51:36 EST
Stromal-Like Environment Critical to Stem Cell Expansion
St. Louis, MO- It is long been suggested that the appropriate imitation of in vivo microenvironments is critical to successful culture, expansion, and differentiation of stem cells. In a paper which appeared in the Nov 9 online issue of Blood (Cytokine and integrin stimulation synergize to promote higher levels of GATA-2, c-myb, and CD34 protein in primary human hematopoietic progenitors...Wednesday November 15th, 2006 @ 01:20:28 EST
Endothelial Stimulation of Hematopoietic Engraftment
Durham, North Carolina Chute et al reported today that administration of mouse endothelial cells to irradiated B6 recipients was capable of accelerating hematopoietic reconstitution after sublethal and lethal irradiation. In a paper entitled "Transplantation of vascular endothelial cells mediates the hematopoietic recovery and survival of lethally irradiated mice" published in today's...Friday November 10th, 2006 @ 12:51:30 EST
Synchronization of Differentiation is Key
LONDON UK Researchers in the UK have published in today's online version of the journal Nature (Maclaren et al. Retinal repair by transplantation of photoreceptor precursors, Nature. 2006 Nov 8.) an important finding in regards to stem cell therapy of photoreceptor loss It was known in the art that transplantation of a wide variety of stem cells into injured retina is usually not capable...Wednesday November 8th, 2006 @ 14:50:25 EST
Stem Cells Follow The Leader
Singapore- Scientists at Viacell announced the ability of unrestricted somatic stem cells (USSC) to enhance migration and repopulation of hematopoietic stem cells in an animal model through secretion of the stem cell chemotactic factor SDF-1. Chan et al in a publication titled "ENHANCED IN VIVO HOMING OF UNCULTURED AND SELECTIVELY AMPLIFIED CORD BLOOD CD34+ CELLS BY CO-TRANSPLANTATION WITH...Thursday October 26th, 2006 @ 11:46:17 EST